Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
CENTURY B and HORWITT MK ROLE OF ARACHIDONIC ACID IN NUTRITIONAL ENCEPHALOMALACIA: INTERRELATIONSHIP OF ESSENTIAL AND NONESSENTIAL POLYUNSATURATED FATTY ACIDS. 1964 Arch. Biochem. Biophys. pmid:14161009
BRESSLER R and FRIEDBERG SJ SUBSTRATE SPECIFICITY OF THE FATTY ACID OXIDASE IN THE HEART. 1964 Arch. Biochem. Biophys. pmid:14161011
Galaris D et al. Ferrylmyoglobin-catalyzed linoleic acid peroxidation. 1990 Arch. Biochem. Biophys. pmid:2383021
PORTMAN OW and SUGANO M THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. 1963 Arch. Biochem. Biophys. pmid:14072510
MATSUSHITA S et al. CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS. 1963 Arch. Biochem. Biophys. pmid:14072524
Draper AJ and Hammock BD Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. 2000 Arch. Biochem. Biophys. pmid:10729206
Hamberg M et al. Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. 1994 Arch. Biochem. Biophys. pmid:8117115
VIOQUE E and HOLMAN RT Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase. 1962 Arch. Biochem. Biophys. pmid:13997422
PORTMAN OW and SUGANO M FACTORS INFLUENCING THE LEVEL AND FATTY ACID SPECIFICITY OF THE CHOLESTEROL ESTERIFICATION ACTIVITY IN HUMAN PLASMA. 1964 Arch. Biochem. Biophys. pmid:14236639
Ashida H et al. Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. 1987 Arch. Biochem. Biophys. pmid:3688880
Hörnsten L et al. Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8806734
Kulkarni AP and Sajan M Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. 1999 Arch. Biochem. Biophys. pmid:10545208
Wennman A et al. Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. 2014 Arch. Biochem. Biophys. pmid:24857825
Angerman-Stewart JA et al. Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. 1995 Arch. Biochem. Biophys. pmid:7733666
Berge RK et al. Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. 1987 Arch. Biochem. Biophys. pmid:2880562
Nemecz G et al. Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. 1991 Arch. Biochem. Biophys. pmid:1897956
SWELL L et al. ROLE OF THE LIVER IN THE METABOLISM OF EXOGENOUS CHOLESTEROL ESTERS. 1964 Arch. Biochem. Biophys. pmid:14236640
Fukuzawa K et al. Site-specific induction of lipid peroxidation by iron in charged micelles. 1988 Arch. Biochem. Biophys. pmid:2829725
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Schwartz J et al. Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. 2009 Arch. Dis. Child. pmid:19193660
Ridsdill-Smith J et al. Induced responses in clover to an herbaceous mite. 2002 Arch. Insect Biochem. Physiol. pmid:12432518
Buckner JS and Hagen MM Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. 2003 Arch. Insect Biochem. Physiol. pmid:12761874
Laaksonen DE et al. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. 2005 Arch. Intern. Med. pmid:15668366
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Paraszkiewicz K et al. Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. 2010 Arch. Microbiol. pmid:20047047
Gustafsson MC et al. Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species. 2001 Arch. Microbiol. pmid:11734890
Rashid S et al. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. 2008 Arch. Ophthalmol. pmid:18268213
Seddon JM et al. Dietary fat and risk for advanced age-related macular degeneration. 2001 Arch. Ophthalmol. pmid:11483088
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Vukovic N et al. An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins. 2010 Arch. Pharm. Res. pmid:20191339
Gwak HS and Chun IK Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins. 2001 Arch. Pharm. Res. pmid:11794538
Canetti L et al. Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. 2014 Arch. Physiol. Biochem. pmid:24320056
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Bonanome A et al. Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. 1992 Arterioscler. Thromb. pmid:1558840
Reaven PD et al. Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. 1994 Arterioscler. Thromb. pmid:8148354
Ettinger WH et al. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. 1994 Arterioscler. Thromb. pmid:8274481
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Belkner J et al. Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15681297
Nagelin MH et al. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18635820
Tsimikas S et al. LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:9888874
Salomaa VV et al. Association of the fatty acid composition of serum phospholipids with hemostatic factors. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9157941
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Chancharme L et al. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10073990
Augé N et al. Uptake of 13-hydroperoxylinoleic acid by cultured cells. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10195919
Gniwotta C et al. Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409317
Rodríguez-Lee M et al. Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16239593
Natarajan R and Nadler JL Lipid inflammatory mediators in diabetic vascular disease. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15166011
Loscalzo J et al. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. 1987 Sep-Oct Arteriosclerosis pmid:3675304
Hennig B et al. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. 1984 Sep-Oct Arteriosclerosis pmid:6477300
Kaduce TL et al. Linoleic acid metabolism and prostaglandin production by cultured bovine pulmonary artery endothelial cells. 1982 Sep-Oct Arteriosclerosis pmid:6751307