Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Wiesner R et al. Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre-activated ferric species. 1996 FEBS Lett. pmid:8766705
Aoshima H Potentiation and inhibition of ionotropic neurotransmitter receptors expressed in Xenopus oocyte by linoleic acid and its hydroperoxide. 1996 J. Neurochem. pmid:8769897
Connolly JM et al. Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. 1996 Nutr Cancer pmid:8771566
Fellner V et al. Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. 1995 J. Dairy Sci. pmid:8786265
Ain Baziz H et al. Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. 1996 Poult. Sci. pmid:8786940
Carnielli VP et al. The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. 1996 Pediatr. Res. pmid:8798265
Porkkala-Sarataho E et al. Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. 1996 Atherosclerosis pmid:8800496
Yamada Y et al. Production of hydroxy fatty acid (10-hydroxy-12(Z)-octadecenoic acid) by Lactobacillus plantarum from linoleic acid and its cardiac effects to guinea pig papillary muscles. 1996 Biochem. Biophys. Res. Commun. pmid:8806645
Hörnsten L et al. Dexamethasone induces bisallylic hydroxylation of polyunsaturated fatty acids by rat liver microsomes. 1996 Arch. Biochem. Biophys. pmid:8806734
Mizushina Y et al. Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. 1996 Biochim. Biophys. Acta pmid:8809118
Kaneko T et al. Cytotoxicity of phosphatidylcholine hydroperoxides is exerted through decomposition of fatty acid hydroperoxide moiety. 1996 Free Radic. Biol. Med. pmid:8818632
Toborek M et al. Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. 1996 J. Lipid Res. pmid:8820108
Hatch GM and McClarty G Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'-triphosphate. 1996 J. Biol. Chem. pmid:8824210
Engberg RM et al. Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. 1996 Poult. Sci. pmid:8829233
Boyd NF et al. Long-term effects of participation in a randomized trial of a low-fat, high-carbohydrate diet. 1996 Cancer Epidemiol. Biomarkers Prev. pmid:8833622
Glickman MH and Klinman JP Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. 1996 Biochemistry pmid:8841132
Venuta A et al. Essential fatty acids: the effects of dietary supplementation among children with recurrent respiratory infections. 1996 Jul-Aug J. Int. Med. Res. pmid:8854285
Hudson JA et al. Hydration of oleic acid by a Selenomonas strain from the ovine rumen. 1996 Lett. Appl. Microbiol. pmid:8862016
Schurz HH et al. Products of aniline and triglycerides in oil samples associated with the toxic oil syndrome. 1996 Chem. Res. Toxicol. pmid:8870988
Schingoethe DJ et al. Lactational responses of dairy cows fed unsaturated fat from extruded soybeans or sunflower seeds. 1996 J. Dairy Sci. pmid:8872718