| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Iwase H et al. | Formation of leukotoxin (9,10-epoxy-12-octadecenoic acid) during the autoxidation of phospholipids promoted by hemoproteins. | 1997 | Biochim. Biophys. Acta | pmid:9084498 |
| Yamaki T et al. | Acute and reversible fatty metamorphosis of cultured rat hepatocytes. | 1997 Feb-Mar | Pathol. Int. | pmid:9088028 |
| Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
| Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
| Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
| Nieuwenhuizen WF et al. | Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. | 1997 | Biochemistry | pmid:9109655 |
| Ip C and Scimeca JA | Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. | 1997 | Nutr Cancer | pmid:9121939 |
| Schneider C et al. | A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9125182 |
| Bourre JM et al. | Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids. | 1997 | Neurosci. Lett. | pmid:9132678 |
| Cunnane SC and Anderson MJ | Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidation. | 1997 | J. Lipid Res. | pmid:9144095 |
| Luthria DL et al. | Metabolites produced during the peroxisomal beta-oxidation of linoleate and arachidonate move to microsomes for conversion back to linoleate. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9144553 |
| Salomaa VV et al. | Association of the fatty acid composition of serum phospholipids with hemostatic factors. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157941 |
| Rogers AE | Diet and breast cancer: studies in laboratory animals. | 1997 | J. Nutr. | pmid:9164267 |
| Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
| Monette M and Lafleur M | Influence of lipid chain unsaturation on melittin-induced micellization. | 1996 | Biophys. J. | pmid:9172743 |
| Matsusue K et al. | A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. | 1997 | Toxicol. Lett. | pmid:9175845 |
| Nakayama T et al. | Lipid peroxidation in linoleic acid micelles caused by H2O2 in the presence of myoglobin. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9178558 |
| Harvei S et al. | Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. | 1997 | Int. J. Cancer | pmid:9178806 |
| Hornstra G and Kester AD | Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model. | 1997 | Atherosclerosis | pmid:9180241 |
| Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
| Banfi C et al. | Linoleic acid enhances the secretion of plasminogen activator inhibitor type 1 by HepG2 cells. | 1997 | J. Lipid Res. | pmid:9186904 |
| Memoli S et al. | Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. | 1997 | Biochim. Biophys. Acta | pmid:9187303 |
| Ek BA et al. | Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. | 1997 | Biochim. Biophys. Acta | pmid:9187305 |
| Berry H et al. | Excess substrate inhibition of soybean lipoxygenase-1 is mainly oxygen-dependent. | 1997 | FEBS Lett. | pmid:9188786 |
| Peres CM et al. | Transference of fatty acids from macrophages to lymphocytes in culture. | 1997 | Biochem. Soc. Trans. | pmid:9191389 |
| Sanderson P et al. | Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. | 1997 | Biochem. Soc. Trans. | pmid:9191396 |
| Sharpe M et al. | Ligation, inhibition, and activation of cytochrome c oxidase by fatty acids. | 1997 | Biochem. Cell Biol. | pmid:9192076 |
| Petrek JA et al. | Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis. | 1997 | J. Clin. Oncol. | pmid:9193329 |
| Sauer LA et al. | Dietary linoleic acid intake controls the arterial blood plasma concentration and the rates of growth and linoleic acid uptake and metabolism in hepatoma 7288CTC in Buffalo rats. | 1997 | J. Nutr. | pmid:9202100 |
| Schut HA et al. | DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. | 1997 | Mutat. Res. | pmid:9202755 |
| Yehuda S et al. | Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. | 1997 | Eur. J. Pharmacol. | pmid:9203563 |
| Stein CA | Controversies in the cellular pharmacology of oligodeoxynucleotides. | 1997 | Antisense Nucleic Acid Drug Dev. | pmid:9212912 |
| Durgam VR and Fernandes G | The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. | 1997 | Cancer Lett. | pmid:9215854 |
| Jira W et al. | Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis. | 1997 | Chem. Phys. Lipids | pmid:9219348 |
| Quoc KP and Dubacq JP | Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. | 1997 | Biochim. Biophys. Acta | pmid:9219908 |
| Shi F et al. | Permeability and metabolic properties of a trophoblast cell line (HRP-1) derived from normal rat placenta. | 1997 | Exp. Cell Res. | pmid:9223380 |
| Haraguchi H et al. | Antioxidative action of diterpenoids from Podocarpus nagi. | 1997 | Planta Med. | pmid:9225601 |
| Lanson M et al. | Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. | 1997 | J Lipid Mediat Cell Signal | pmid:9246607 |
| Hannah JS et al. | High fat, high cholesterol diets alter low density lipoprotein size and binding affinity in monkeys. | 1997 | Atherosclerosis | pmid:9247355 |
| Thomson AB et al. | Nutrient uptake into undifferentiated and differentiated HT-29 cells in culture. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9250367 |
| Bosca F et al. | Photophysical and photochemical characterization of a photosensitizing drug: a combined steady state photolysis and laser flash photolysis study on carprofen. | 1997 | Chem. Res. Toxicol. | pmid:9250417 |
| Parmentier HK et al. | Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. | 1997 | Poult. Sci. | pmid:9251147 |
| Howlett NG and Avery SV | Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. | 1997 | Appl. Environ. Microbiol. | pmid:9251184 |
| Siguel E | Essential fatty acid status in patients. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252955 |
| Castelli F et al. | Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesicles as model membranes for studies on novel free-radical scavengers. | 1997 | J Pharmacol Toxicol Methods | pmid:9253749 |
| Risé P et al. | Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. | 1997 | J. Lipid Res. | pmid:9254057 |
| Bakker N et al. | Adipose fatty acids and cancers of the breast, prostate and colon: an ecological study. EURAMIC Study Group. | 1997 | Int. J. Cancer | pmid:9259395 |
| Badart-Smook A et al. | Fetal growth is associated positively with maternal intake of riboflavin and negatively with maternal intake of linoleic acid. | 1997 | J Am Diet Assoc | pmid:9259708 |
| Feussner I et al. | Structural elucidation of oxygenated storage lipids in cucumber cotyledons. Implication of lipid body lipoxygenase in lipid mobilization during germination. | 1997 | J. Biol. Chem. | pmid:9261186 |
| Jenkins TC | Ruminal fermentation and nutrient digestion in sheep fed hydroxyethylsoyamide. | 1997 | J. Anim. Sci. | pmid:9263076 |