Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Haggarty P et al. | Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. | 1999 | Biol. Neonate | pmid:10325438 |
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Kapich A et al. | Coupling of manganese peroxidase-mediated lipid peroxidation with destruction of nonphenolic lignin model compounds and 14C-labeled lignins. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334942 |
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Meuillet EJ et al. | Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. | 1999 | Biochim. Biophys. Acta | pmid:10354513 |
Fukushima M et al. | Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. | 1999 | Nutrition | pmid:10355850 |
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Alava MA et al. | Fatty acid desaturation: effect of alphafetoprotein on alpha-linolenic acid conversion by fetal rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359023 |
Dodge ML et al. | Glutathione peroxidase activity modulates fatty acid profiles of plasma and breast milk in Chinese women. | 1999 | J Trace Elem Med Biol | pmid:10365375 |
Stimers JR et al. | Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. | 1999 | Biochim. Biophys. Acta | pmid:10366778 |
Kavanaugh CJ et al. | Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. | 1999 | Nutr Cancer | pmid:10368807 |
Gänzle MG et al. | Resistance of Escherichia coli and Salmonella against nisin and curvacin A. | 1999 | Int. J. Food Microbiol. | pmid:10375133 |
Forster C et al. | Molecular analysis of a null mutant for pea (Pisum sativum L.) seed lipoxygenase-2. | 1999 | Plant Mol. Biol. | pmid:10380807 |
Akeo K et al. | Effects of fluorescent light on growth of bovine retinal pigment epithelial cells in vitro incubated with linoleic acid or linoleic acid hydroperoxide. | 1999 | Pigment Cell Res. | pmid:10385917 |
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Jiang J et al. | Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. | 1999 | Am. J. Clin. Nutr. | pmid:10393134 |
Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
Su HM et al. | Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. | 1999 | J. Lipid Res. | pmid:10393215 |
Ando H et al. | Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis. | 1999 | J. Lipid Res. | pmid:10393216 |
Hidaka T et al. | Screening of microbial products modifying the action of leptin (obese gene product) by a biosensor. | 1999 | J. Antibiot. | pmid:10395281 |
Ingkaninan K et al. | Interference of linoleic acid fraction in some receptor binding assays. | 1999 | J. Nat. Prod. | pmid:10395519 |
Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
O'Donnell VB et al. | 15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase. | 1999 | J. Biol. Chem. | pmid:10400618 |
Dontsov AE et al. | Retinal pigment epithelium pigment granules stimulate the photo-oxidation of unsaturated fatty acids. | 1999 | Free Radic. Biol. Med. | pmid:10401607 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Ding XZ et al. | Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10405349 |
Kim S et al. | C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. | 1999 | Mol. Cell. Biol. | pmid:10409760 |
Sammon AM | Maize meal, non-esterified linoleic acid, and endemic cancer of the esophagus--preliminary findings. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410386 |
Demmelmair H et al. | Comparison of bolus versus fractionated oral applications of [13C]-linoleic acid in humans. | 1999 | Eur. J. Clin. Invest. | pmid:10411666 |
Calvo AM et al. | Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. | 1999 | Appl. Environ. Microbiol. | pmid:10427064 |
Yamasaki M et al. | Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10427699 |
Rudel LL | Atherosclerosis and conjugated linoleic acid. | 1999 | Br. J. Nutr. | pmid:10434843 |
Ahn DU et al. | Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. | 1999 | Poult. Sci. | pmid:10438141 |
Jarmuszkiewicz W et al. | Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii. | 1999 | J. Biol. Chem. | pmid:10438491 |
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Park JY et al. | Role of hyperpolarization attained by linoleic acid in chick myoblast fusion. | 1999 | Exp. Cell Res. | pmid:10471316 |
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Sauer LA et al. | 13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo. | 1999 | Cancer Res. | pmid:10493526 |
Blask DE et al. | Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. | 1999 | Cancer Res. | pmid:10493527 |
Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
Tamatani T et al. | Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase. | 1999 | Int. J. Oncol. | pmid:10493957 |
Masella R et al. | Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. | 1999 | Redox Rep. | pmid:10496414 |
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Minich DM et al. | Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. | 1999 | Biochim. Biophys. Acta | pmid:10526224 |
Dauchy RT et al. | Dim light during darkness stimulates tumor progression by enhancing tumor fatty acid uptake and metabolism. | 1999 | Cancer Lett. | pmid:10529012 |
Filley SJ et al. | Prostaglandin f(2alpha) concentrations, fatty acid profiles, and fertility in lipid-infused postpartum beef heifers. | 1999 | Biol. Reprod. | pmid:10529280 |
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Murphy J et al. | Fat malabsorption in cystic fibrosis patients. | 1999 | Am. J. Clin. Nutr. | pmid:10539762 |
Kulkarni AP and Sajan M | Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. | 1999 | Arch. Biochem. Biophys. | pmid:10545208 |
Domingo N et al. | Effects of dexamethasone and linoleic acid on hepatic secretion of biliary lipids and anionic polypeptide factor: In vivo and in vitro studies. | 1999 Nov-Dec | Digestion | pmid:10545720 |
Sánchez-Vioque R et al. | Interaction of chickpea (Cicer arietinum L.) legumin with oxidized linoleic acid. | 1999 | J. Agric. Food Chem. | pmid:10552371 |
Angerosa F et al. | Virgin olive oil volatile compounds from lipoxygenase pathway and characterization of some italian cultivars. | 1999 | J. Agric. Food Chem. | pmid:10552376 |
Budi Santosa FX and Padua GW | Tensile properties and water absorption of zein sheets plasticized with oleic and linoleic acids. | 1999 | J. Agric. Food Chem. | pmid:10552498 |
Henderson DE et al. | Quantitative HPLC determination of the antioxidant activity of capsaicin on the formation of lipid hydroperoxides of linoleic acid: a comparative study against BHT and melatonin. | 1999 | J. Agric. Food Chem. | pmid:10552527 |
Kuo JM et al. | Rapid photometric assay evaluating antioxidative activity in edible plant material. | 1999 | J. Agric. Food Chem. | pmid:10552632 |
Grobas S et al. | Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. | 1999 | Poult. Sci. | pmid:10560827 |
Du M et al. | Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. | 1999 | Poult. Sci. | pmid:10560841 |
López-Nicolás JM et al. | Rapid reversed-phase high-performance liquid chromatographic determination of the regiospecificity of lipoxygenase products on linoleic acid. | 1999 | J Chromatogr A | pmid:10563421 |