Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Anton SD et al. | Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health. | 2013 | J Integr Med | pmid:23464640 |
| Mabalirajan U et al. | Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. | 2013 | Sci Rep | pmid:23443229 |
| Tokede OA et al. | Plasma phospholipid trans fatty acids and risk of heart failure. | 2013 | Am. J. Clin. Nutr. | pmid:23446892 |
| Schneider MR et al. | Differentially regulated microRNAs during human sebaceous lipogenesis. | 2013 | J. Dermatol. Sci. | pmid:23452545 |
| Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
| Lind PM et al. | An environmental wide association study (EWAS) approach to the metabolic syndrome. | 2013 | Environ Int | pmid:23454278 |
| Toral PG et al. | Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. | 2013 | J. Dairy Sci. | pmid:23164228 |
| Poon JF et al. | In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. | 2013 | J. Org. Chem. | pmid:23701313 |
| Chodok P et al. | Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23702573 |
| Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
| Hashim A et al. | Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study. | 2013 | Biomed Res Int | pmid:23957001 |
| Kim JB et al. | Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. | 2013 | Am. J. Cardiol. | pmid:24050409 |
| Okada Y et al. | Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. | 2013 | Clin. Exp. Immunol. | pmid:24028683 |
| Vukašinović EL et al. | Diapause induces changes in the composition and biophysical properties of lipids in larvae of the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23701990 |
| Ramsden CE et al. | Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959954 |
| Alinezhad H et al. | Biochemical activities of acetone extracts of Hyssopus angustifolius. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876603 |
| Moghaddam AH et al. | Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876611 |
| Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
| Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
| Chivandi E et al. | Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. | 2012 Jan-Feb | In Vivo | pmid:22210722 |
| Fu J et al. | Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. | 2012 | J. Food Sci. | pmid:22747885 |
| Chiou TY et al. | Extraction of defatted rice bran with subcritical aqueous acetone. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878207 |
| Wajid NA and Halpern BP | Oral cavity discrimination of vapor-phase long-chain 18-carbon fatty acids. | 2012 | Chem. Senses | pmid:22459162 |
| Ménard N et al. | Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. | 2012 | Pharm. Res. | pmid:22451248 |
| Smith AN et al. | Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators. | 2012 | J. Cell. Physiol. | pmid:22105830 |
| Martorell P et al. | Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: the specific case of a conjugated linoleic acid mixture (Tonalin). | 2012 | J. Agric. Food Chem. | pmid:23072574 |
| Hu ZP et al. | Metabonomic profiling of TASTPM transgenic Alzheimer's disease mouse model. | 2012 | J. Proteome Res. | pmid:23078235 |
| Heinze VM and Actis AB | Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review. | 2012 | Int J Food Sci Nutr | pmid:21762028 |
| Celia C et al. | Ethosomes® and transfersomes® containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders. | 2012 | Biomed Microdevices | pmid:21960035 |
| Yumrutas O et al. | Phenolic acid contents, essential oil compositions and antioxidant activities of two varieties of Salvia euphratica from Turkey. | 2012 | Nat. Prod. Res. | pmid:21995274 |
| Tyagi A et al. | Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. | 2012 | Br. J. Nutr. | pmid:22243775 |
| Kurotani K et al. | High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | 2012 | Nutr Res | pmid:23084639 |
| Trevizan L et al. | Maintenance of arachidonic acid and evidence of Δ5 desaturation in cats fed γ-linolenic and linoleic acid enriched diets. | 2012 | Lipids | pmid:22249937 |
| Osuji GO et al. | Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. | 2012 | Appl. Biochem. Biotechnol. | pmid:22918723 |
| Mukherjee S et al. | NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. | 2012 | J. Biol. Chem. | pmid:22923617 |
| Regensburger J et al. | Fatty acids and vitamins generate singlet oxygen under UVB irradiation. | 2012 | Exp. Dermatol. | pmid:22229443 |
| Mormile R et al. | Linoleic acid and colorectal cancer cell growth suppression: is the deregulation of mitochondrial survivin the key factor? | 2012 | Int J Colorectal Dis | pmid:22231621 |
| Luévano-MartÃnez LA et al. | A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. | 2012 | Biochem. J. | pmid:22236206 |
| Jorge AT et al. | Schinus terebinthifolius Raddi extract and linoleic acid from Passiflora edulis synergistically decrease melanin synthesis in B16 cells and reconstituted epidermis. | 2012 | Int J Cosmet Sci | pmid:22738140 |
| Tao XM et al. | Enhanced anticancer activity of gemcitabine coupling with conjugated linoleic acid against human breast cancer in vitro and in vivo. | 2012 | Eur J Pharm Biopharm | pmid:22728546 |
| Park EY et al. | Effects of peptide fractions with different isoelectric points from wheat gluten hydrolysates on lipid oxidation in pork meat patties. | 2012 | J. Agric. Food Chem. | pmid:22747172 |
| Pestana JM et al. | Effect of slaughter season and muscle type on the fatty acid composition, including conjugated linoleic acid isomers, and nutritional value of intramuscular fat in organic beef. | 2012 | J. Sci. Food Agric. | pmid:22473659 |
| MartÃnez MarÃn AL et al. | Effects of feeding increasing dietary levels of high oleic or regular sunflower or linseed oil on fatty acid profile of goat milk. | 2012 | J. Dairy Sci. | pmid:22459841 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| da Silva Acosta D et al. | Fullerene and omega-3 and omega-6 fatty acids on fish brain antioxidant status. | 2012 | Fish Physiol. Biochem. | pmid:22451341 |
| Cerretani L et al. | DSC evaluation of extra virgin olive oil stability under accelerated oxidative test: effect of fatty acid composition and phenol contents. | 2012 | J Oleo Sci | pmid:22687775 |
| Hill S et al. | Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. | 2012 | Free Radic. Biol. Med. | pmid:22705367 |
| Kamitani S et al. | Differences between group X and group V secretory phospholipase A(2) in lipolytic modification of lipoproteins. | 2012 | Cell. Mol. Biol. Lett. | pmid:22706677 |
| Wiebe MG et al. | Lipid production in batch and fed-batch cultures of Rhodosporidium toruloides from 5 and 6 carbon carbohydrates. | 2012 | BMC Biotechnol. | pmid:22646156 |
| Itakura H et al. | The change in low-density lipoprotein cholesterol concentration is positively related to plasma docosahexaenoic acid but not eicosapentaenoic acid. | 2012 | J. Atheroscler. Thromb. | pmid:22653220 |