Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ménard N et al. | Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. | 2012 | Pharm. Res. | pmid:22451248 |
Harvey KA et al. | Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. | 2012 | Lipids | pmid:22684911 |
Montaño M et al. | New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. | 2012 | Toxicol. Sci. | pmid:22859314 |
Bonacci G et al. | Conjugated linoleic acid is a preferential substrate for fatty acid nitration. | 2012 | J. Biol. Chem. | pmid:23144452 |
Gutla PV et al. | Modulation of plant TPC channels by polyunsaturated fatty acids. | 2012 | J. Exp. Bot. | pmid:23105130 |
Ebba S et al. | The examination of fatty acid taste with edible strips. | 2012 | Physiol. Behav. | pmid:22521910 |
Smith AN et al. | Unsaturated fatty acids induce mesenchymal stem cells to increase secretion of angiogenic mediators. | 2012 | J. Cell. Physiol. | pmid:22105830 |
Ruparel S et al. | Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. | 2012 | Pain | pmid:22633978 |
Shimomura K et al. | Identification of the plant origin of propolis from Jeju Island, Korea, by observation of honeybee behavior and phytochemical analysis. | 2012 | Biosci. Biotechnol. Biochem. | pmid:23132582 |
Dramane G et al. | STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. | 2012 | J. Clin. Invest. | pmid:22546859 |
Naqvi AZ et al. | Dietary fatty acids and peripheral artery disease in adults. | 2012 | Atherosclerosis | pmid:22552117 |
Joshi S et al. | Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | 2012 | Org. Biomol. Chem. | pmid:22986997 |
Perdriau S et al. | Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. | 2012 | ChemSusChem | pmid:23060315 |
O'Donnell-Megaro AM et al. | Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. | 2012 | J. Dairy Sci. | pmid:23063161 |
Krugner-Higby L et al. | Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. | 2012 | Comp. Med. | pmid:23043777 |
Coimbra MC and Jorge N | Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). | 2012 | J. Sci. Food Agric. | pmid:21922463 |
Han SN et al. | Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. | 2012 | J. Nutr. | pmid:23096013 |
Marincola FC et al. | A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. | 2012 | J. Matern. Fetal. Neonatal. Med. | pmid:23025771 |
Martorell P et al. | Caenorhabditis elegans as a model to study the effectiveness and metabolic targets of dietary supplements used for obesity treatment: the specific case of a conjugated linoleic acid mixture (Tonalin). | 2012 | J. Agric. Food Chem. | pmid:23072574 |
Kanter JE et al. | Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. | 2012 | Biochim. Biophys. Acta | pmid:22020260 |
Poompachee K and Chudapongse N | Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. | 2012 | Med Princ Pract | pmid:22024634 |
Sandoval-Montemayor NE et al. | Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. | 2012 | Molecules | pmid:22992784 |
de Batlle J et al. | Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. | 2012 | J. Nutr. Biochem. | pmid:21889886 |
Florence AC et al. | Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. | 2012 | Food Chem | pmid:22980792 |
Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
Regensburger J et al. | Fatty acids and vitamins generate singlet oxygen under UVB irradiation. | 2012 | Exp. Dermatol. | pmid:22229443 |
Stachowska E et al. | Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. | 2012 | Int J Food Sci Nutr | pmid:21721848 |
Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
Levitan EB et al. | α-Linolenic acid, linoleic acid and heart failure in women. | 2012 | Br. J. Nutr. | pmid:22172525 |
Taârit MB et al. | Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. | 2012 | J. Sci. Food Agric. | pmid:22173568 |
Byun HJ et al. | Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. | 2012 | J. Dermatol. Sci. | pmid:22209282 |
Cheguru P et al. | Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. | 2012 | Pflugers Arch. | pmid:22218833 |
Ogawa N et al. | Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. | 2012 | Metab. Clin. Exp. | pmid:22445513 |
Beevi SS et al. | Polyphenolics profile and antioxidant properties of Raphanus sativus L. | 2012 | Nat. Prod. Res. | pmid:21714734 |
Zengin G et al. | Composition of essential oil and antioxidant capacity of Centaurea drabifolia Sm. subsp. detonsa (Bornm.) Wagenitz, endemic to Turkey. | 2012 | Nat. Prod. Res. | pmid:21714737 |
Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
Zein CO et al. | Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. | 2012 | Hepatology | pmid:22505276 |
Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Zened A et al. | In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. | 2012 | Animal | pmid:22436225 |
Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
Passos PP et al. | Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. | 2012 | J. Chem. Neuroanat. | pmid:22687395 |
Wu J et al. | Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. | 2012 | Acta Biochim. Biophys. Sin. (Shanghai) | pmid:22687573 |
Reynolds CM et al. | Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. | 2012 | Mol Nutr Food Res | pmid:22700321 |
Ladeira MM et al. | Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. | 2012 | Recent Pat Food Nutr Agric | pmid:22702746 |
Kamitani S et al. | Differences between group X and group V secretory phospholipase A(2) in lipolytic modification of lipoproteins. | 2012 | Cell. Mol. Biol. Lett. | pmid:22706677 |
Monteiro J et al. | Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. | 2012 | Lipids Health Dis | pmid:22642787 |
Yu T et al. | Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. | 2012 | Pflugers Arch. | pmid:22644615 |
de Sousa Ferreira Soares G et al. | Spectroscopic and thermooxidative analysis of organic okra oil and seeds from Abelmoschus esculentus. | 2012 | ScientificWorldJournal | pmid:22645459 |
Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |