Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fuller MA et al. | Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. | 2001 | Arch. Biochem. Biophys. | pmid:11361131 |
Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
Guha SN et al. | Free radical reductive degradation of vic-dibromoalkanes and reaction of bromine atoms with polyunsaturated fatty acids: possible involvement of Br(.) in the 1,2-dibromoethane-induced lipid peroxidation. | 1993 | Arch. Biochem. Biophys. | pmid:8342946 |
KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. | 1958 | Arch. Biochem. Biophys. | pmid:13560012 |
Winterbourn CC et al. | Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid. | 1992 | Arch. Biochem. Biophys. | pmid:1321589 |
KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
Sánchez J and Stumpf PK | The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. | 1984 | Arch. Biochem. Biophys. | pmid:6696430 |
Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
MEDES G et al. | Dienoic acid contents of rats with linoleic acid and pyridoxine deficiencies. | 1951 | Arch. Biochem. Biophys. | pmid:14847665 |
Wennman A et al. | Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. | 2014 | Arch. Biochem. Biophys. | pmid:24857825 |
Duthie GG et al. | Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. | 1992 | Arch. Biochem. Biophys. | pmid:1632646 |
PRIVETT OS et al. | Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. | 1955 | Arch. Biochem. Biophys. | pmid:13239196 |
TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
TAPPEL AL | The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. | 1953 | Arch. Biochem. Biophys. | pmid:13058395 |
Laidler P et al. | Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? | 2007 | Arch. Biochem. Biophys. | pmid:17466258 |
Hamberg M | Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. | 1998 | Arch. Biochem. Biophys. | pmid:9448728 |
KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
Olveira G et al. | Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. | 2010 | Arch. Bronconeumol. | pmid:20045240 |
Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
Ridsdill-Smith J et al. | Induced responses in clover to an herbaceous mite. | 2002 | Arch. Insect Biochem. Physiol. | pmid:12432518 |
Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
Laaksonen DE et al. | Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. | 2005 | Arch. Intern. Med. | pmid:15668366 |
Rasic-Milutinovic Z et al. | Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. | 2012 | Arch. Med. Res. | pmid:22222492 |
Paraszkiewicz K et al. | Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. | 2010 | Arch. Microbiol. | pmid:20047047 |
Gustafsson MC et al. | Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species. | 2001 | Arch. Microbiol. | pmid:11734890 |
Rashid S et al. | Topical omega-3 and omega-6 fatty acids for treatment of dry eye. | 2008 | Arch. Ophthalmol. | pmid:18268213 |
Seddon JM et al. | Dietary fat and risk for advanced age-related macular degeneration. | 2001 | Arch. Ophthalmol. | pmid:11483088 |
Huang CB et al. | Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. | 2010 | Arch. Oral Biol. | pmid:20541177 |
Vukovic N et al. | An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins. | 2010 | Arch. Pharm. Res. | pmid:20191339 |
Gwak HS and Chun IK | Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins. | 2001 | Arch. Pharm. Res. | pmid:11794538 |
Canetti L et al. | Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. | 2014 | Arch. Physiol. Biochem. | pmid:24320056 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Bonanome A et al. | Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. | 1992 | Arterioscler. Thromb. | pmid:1558840 |
Reaven PD et al. | Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. | 1994 | Arterioscler. Thromb. | pmid:8148354 |
Ettinger WH et al. | Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. | 1994 | Arterioscler. Thromb. | pmid:8274481 |
Won JC et al. | Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:19965780 |
Belkner J et al. | Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15681297 |
Nagelin MH et al. | 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18635820 |
Tsimikas S et al. | LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9888874 |
Salomaa VV et al. | Association of the fatty acid composition of serum phospholipids with hemostatic factors. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157941 |
Mennen L et al. | Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9555866 |
Chancharme L et al. | Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073990 |
Augé N et al. | Uptake of 13-hydroperoxylinoleic acid by cultured cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195919 |
Gniwotta C et al. | Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409317 |
RodrÃguez-Lee M et al. | Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16239593 |
Natarajan R and Nadler JL | Lipid inflammatory mediators in diabetic vascular disease. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15166011 |
Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
Hennig B et al. | Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. | 1984 Sep-Oct | Arteriosclerosis | pmid:6477300 |
Kaduce TL et al. | Linoleic acid metabolism and prostaglandin production by cultured bovine pulmonary artery endothelial cells. | 1982 Sep-Oct | Arteriosclerosis | pmid:6751307 |