Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Smedman A et al. | Isomer-specific effects of conjugated linoleic acid on lipid peroxidation in humans: regulation by alpha-tocopherol and cyclo-oxygenase-2 inhibitor. | 2004 | Clin. Sci. | pmid:12956622 |
| Corino C et al. | Effect of conjugated linoleic acid on meat quality, lipid metabolism, and sensory characteristics of dry-cured hams from heavy pigs. | 2003 | J. Anim. Sci. | pmid:12968697 |
| Ogborn MR et al. | Dietary conjugated linoleic acid reduces PGE2 release and interstitial injury in rat polycystic kidney disease. | 2003 | Kidney Int. | pmid:12969139 |
| TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
| KHAN NA | Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. | 1953 | Arch. Biochem. Biophys. | pmid:13058378 |
| TAPPEL AL | The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. | 1953 | Arch. Biochem. Biophys. | pmid:13058395 |
| BUTCHER EO | The penetration of fat and fatty acid into the skin of the rat. | 1953 | J. Invest. Dermatol. | pmid:13069840 |
| Cleland LG et al. | Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. | 1992 | Am. J. Clin. Nutr. | pmid:1310374 |
| Allgayer H et al. | Superoxide, hydroxyl and fatty acid radical scavenging by aminosalicylates. Direct evaluation with electron spin resonance spectroscopy. | 1992 | Biochem. Pharmacol. | pmid:1310851 |
| Dwight JF et al. | Membrane incorporation of non-esterified fatty acids and effects on the sodium pump of human erythrocytes. | 1992 | Clin. Sci. | pmid:1310925 |
| Albro PW et al. | Isolation and characterization of the initial radical adduct formed from linoleic acid and alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone in the presence of soybean lipoxygenase. | 1992 | Chem. Biol. Interact. | pmid:1312396 |
| Tanaka N et al. | Antioxidative capacity of extracts and constituents in Cornus capitata adventitious roots. | 2003 | J. Agric. Food Chem. | pmid:13129293 |
| Kelly O et al. | The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. | 2003 | Br. J. Nutr. | pmid:13129442 |
| Hsu JM and Ding ST | Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. | 2003 | Br. J. Nutr. | pmid:13129455 |
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| Matsumoto M et al. | D-galactosamine-induced cell damage enhances specific binding of prostaglandin E1 to rat hepatocytes. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1315527 |
| Huang SC et al. | Dietary fat influences Ia antigen expression and immune cell populations in the murine peritoneum and spleen. | 1992 | J. Nutr. | pmid:1316956 |
| Winterbourn CC et al. | Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid. | 1992 | Arch. Biochem. Biophys. | pmid:1321589 |
| BLOMSTRAND R | The intestinal absorption of linoleic-1-14C acid. | 1954 | Acta Physiol. Scand. | pmid:13228101 |
| Kang JX et al. | The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. | 1992 | Biochem. J. | pmid:1323271 |
| PRIVETT OS et al. | Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. | 1955 | Arch. Biochem. Biophys. | pmid:13239196 |
| Jannace PW et al. | Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. | 1992 | Am. J. Clin. Nutr. | pmid:1323926 |
| Britton M et al. | Diet as a source of phospholipid esterified 9,11-octadecadienoic acid in humans. | 1992 | Clin. Sci. | pmid:1325328 |
| pmid:13272072 | ||||
| MEAD JF et al. | Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. | 1956 | J. Biol. Chem. | pmid:13278347 |
| SIDDIQI AM and TAPPEL AL | Catalysis of linoleate oxidation by pea lipoxidase. | 1956 | Arch. Biochem. Biophys. | pmid:13283592 |
| Imagawa W et al. | Pregnancy-dependent to ovarian-independent progression in mammary tumors delineated in primary culture: changes in signal transduction, growth factor regulation, and matrix interaction. | 1992 | Cancer Res. | pmid:1330295 |
| STEINBERG G et al. | Metabolism of essential fatty acids. IV. Incorporation of linoleate into arachidonic acid. | 1956 | J. Biol. Chem. | pmid:13319343 |
| Hui R et al. | Inhibition of vasopressin-induced formation of diradylglycerols in vascular smooth muscle cells by incorporation of eicosapentaenoic acid in membrane phospholipids. | 1992 | J. Hypertens. | pmid:1334995 |
| FISHER H and LEVEILLE GA | Observations on the cholesterol, linoleic and linolenic acid content of eggs as influenced by dietary fats. | 1957 | J. Nutr. | pmid:13476240 |
| HORGAN VJ et al. | Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. | 1957 | Biochem. J. | pmid:13488907 |
| pmid:13489152 | ||||
| TOOKEY HL et al. | Coupled oxidation of carotene and linoleate catalyzed by lipoxidase. | 1958 | J. Biol. Chem. | pmid:13502374 |
| Gibson RA et al. | Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. | 1992 | Biochim. Biophys. Acta | pmid:1351403 |
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| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. | 1958 | Arch. Biochem. Biophys. | pmid:13560012 |
| OLSON FE et al. | The use of diets containing large amounts of linoleic acid. | 1958 Nov-Dec | Am. J. Clin. Nutr. | pmid:13594895 |
| KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
| WIESE HF et al. | Essential fatty acids in infant nutrition. I. Linoleic acid requirement in terms of serum di-, tri- and tetraenoic acid levels. | 1958 | J. Nutr. | pmid:13611579 |
| pmid:13621280 | ||||
| HANSEN AE et al. | Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. | 1958 | J. Nutr. | pmid:13621281 |
| HAUGE JG and NICOLAYSEN R | The serum cholesterol depressive effect of linoleic, linolenic acids and of cod liver oil in experimental hypercholesterolaemic rats. | 1959 | Acta Physiol. Scand. | pmid:13626601 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
| pmid:13652745 | ||||
| FULD H and HORWICH L | Xanthomatous biliary cirrhosis treated with ethyl linoleate. | 1959 | Lancet | pmid:13655619 |
| pmid:13673307 | ||||
| Saturnino C et al. | Antioxidant activity of thioureidic derivatives I. | 2003 | Farmaco | pmid:13679175 |
| Koba K et al. | Effects of alpha-tocopherol and tocotrienols on blood pressure and linoleic acid metabolism in the spontaneously hypertensive rat (SHR). | 1992 | Biosci. Biotechnol. Biochem. | pmid:1368948 |