Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Genetic Diseases, X-Linked D040181 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Lymphopenia D008231 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Melanosis D008548 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Otitis Externa D010032 8 associated lipids
Hypertension, Renal D006977 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Glucose Intolerance D018149 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Alopecia D000505 14 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Tuberculosis D014376 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Birth Weight D001724 23 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Kidney Diseases D007674 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Diseases D008107 31 associated lipids
Heart Failure D006333 36 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Fatty Liver D005234 48 associated lipids
Precancerous Conditions D011230 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Leukemia D007938 74 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Shechter Y et al. Evaluation of factors responsible for the inability of insulin to antagonize lipolysis due to high concentrations of catecholamines. 1982 Biochem. Biophys. Res. Commun. pmid:6297490
Campbell FM et al. Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. 1995 Biochem. Biophys. Res. Commun. pmid:7733952
Hicks M et al. Catalysis of lipid peroxidation by glucose and glycosylated collagen. 1988 Biochem. Biophys. Res. Commun. pmid:3126742
Lee CW et al. Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. 2015 Biochem. Biophys. Res. Commun. pmid:26206084
Pohl CH et al. Oxylipin formation in fungi: biotransformation of arachidonic acid to 3-hydroxy-5,8-tetradecadienoic acid by Mucor genevensis. 1998 Biochem. Biophys. Res. Commun. pmid:9918790
Schächtele C et al. Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. 1988 Biochem. Biophys. Res. Commun. pmid:2831891
Inoue N et al. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. 2004 Biochem. Biophys. Res. Commun. pmid:15369804
Laugier C et al. Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. 1991 Biochem. Biophys. Res. Commun. pmid:1645959
Kelley RI Beta-oxidation of long-chain fatty acids by human fibroblasts: evidence for a novel long-chain acyl-coenzyme A dehydrogenase. 1992 Biochem. Biophys. Res. Commun. pmid:1540149
Lernhardt W Fatty acid requirement of B lymphocytes activated in vitro. 1990 Biochem. Biophys. Res. Commun. pmid:2302243
Kang K and Pariza MW trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. 2001 Biochem. Biophys. Res. Commun. pmid:11554738
Yara A et al. Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. 2008 Biochem. Biophys. Res. Commun. pmid:18373976
Iwase H et al. pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. 1995 Biochem. Biophys. Res. Commun. pmid:7488065
Conquer J and Mahadevappa VG Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. 1990 Biochem. Biophys. Res. Commun. pmid:2106881
Takahashi K et al. Ester-exchange catalyzed by lipase modified with polyethylene glycol. 1985 Biochem. Biophys. Res. Commun. pmid:4052065
D'Aquino M et al. Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. 1989 Biochem. Biophys. Res. Commun. pmid:2568114
Butovich IA et al. Oxidation of linoleyl alcohol by potato tuber lipoxygenase: possible mechanism and the role of carboxylic group in substrate binding. 1998 Biochem. Biophys. Res. Commun. pmid:9712698
Reinaud O et al. Oxidative metabolism of linoleic acid by human leukocytes. 1989 Biochem. Biophys. Res. Commun. pmid:2735926
Aki T et al. Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase. 1999 Biochem. Biophys. Res. Commun. pmid:10049752
Yamada Y et al. Production of hydroxy fatty acid (10-hydroxy-12(Z)-octadecenoic acid) by Lactobacillus plantarum from linoleic acid and its cardiac effects to guinea pig papillary muscles. 1996 Biochem. Biophys. Res. Commun. pmid:8806645
Sani BP et al. Interference of retinoic acid binding to its binding protein by omega-6 fatty acids. 1987 Biochem. Biophys. Res. Commun. pmid:2820396
Böhmer S et al. Oxidation of phenanthrene by a fungal laccase in the presence of 1-hydroxybenzotriazole and unsaturated lipids. 1998 Biochem. Biophys. Res. Commun. pmid:9514895
Chen Q et al. Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. 2011 Biochem. Biophys. Res. Commun. pmid:21679695
Murakami K et al. Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. 1999 Biochem. Biophys. Res. Commun. pmid:10403814
Jiang WG et al. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. 1998 Biochem. Biophys. Res. Commun. pmid:9514943
Nakagawa Y and Waku K Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists. 1988 Biochem. Biophys. Res. Commun. pmid:3142466
Ou L et al. Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. 2007 Biochem. Biophys. Res. Commun. pmid:17400188
Blee E and Schuber F Enantioselectivity of the hydrolysis of linoleic acid monoepoxides catalyzed by soybean fatty acid epoxide hydrolase. 1992 Biochem. Biophys. Res. Commun. pmid:1520297
Tripathi AK et al. A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. 2002 Biochem. Biophys. Res. Commun. pmid:11779214
Lopez Jimenez JA et al. Linoleic acid metabolism in primary cultures of adult rat cardiomyocytes is impaired by aging. 1997 Biochem. Biophys. Res. Commun. pmid:9266846
Nagao K et al. The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. 2003 Biochem. Biophys. Res. Commun. pmid:12788078
Maccarrone M et al. Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10833416
Hernández-Ledesma B et al. Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. 2009 Biochem. Biophys. Res. Commun. pmid:19836349
Stentz FB and Kitabchi AE Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation. 2006 Biochem. Biophys. Res. Commun. pmid:16782068
Das UN Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro. 1988 Biochem. Biophys. Res. Commun. pmid:3144272
Luthria DL et al. Metabolites produced during the peroxisomal beta-oxidation of linoleate and arachidonate move to microsomes for conversion back to linoleate. 1997 Biochem. Biophys. Res. Commun. pmid:9144553
Setty BN et al. 13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells. 1987 Biochem. Biophys. Res. Commun. pmid:3113422
Sharpe M et al. Ligation, inhibition, and activation of cytochrome c oxidase by fatty acids. 1997 Biochem. Cell Biol. pmid:9192076
Stewart JM et al. Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals. 1998 Biochem. Cell Biol. pmid:10099779
Poirier H et al. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. 2001 Biochem. J. pmid:11284737
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. 1963 Biochem. J. pmid:14071526
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. 1963 Biochem. J. pmid:14071527
LEAT WM FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. 1963 Biochem. J. pmid:14097364
Carpenter KL et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. 1994 Biochem. J. pmid:7999000
Lang I et al. A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. 2008 Biochem. J. pmid:18031288
Babizhayev MA et al. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. 1994 Biochem. J. pmid:7998987
Hughes RK et al. Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. 1998 Biochem. J. pmid:9639559
Arslan P et al. cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. 1984 Biochem. J. pmid:6696740
Rayner BS et al. Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution. 2004 Biochem. J. pmid:15035657
Griffiths G et al. Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). 1988 Biochem. J. pmid:3421914