Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ng LL and Hockaday TD | Influence of dietary linoleic acid on leucocyte sodium transport and blood pressure. | 1986 | Br Med J (Clin Res Ed) | pmid:3092960 |
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Bandyopadhyay GK et al. | Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor. | 1987 | J. Biol. Chem. | pmid:3102474 |
Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
Mikhailidis DP et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1987 | Eur. J. Clin. Invest. | pmid:3106056 |
Quik M | Evidence for an involvement of membrane lipids in the control of neuronal nicotinic receptor function using bungarotoxin II-S1. | 1987 | J. Neurochem. | pmid:3106571 |
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Mackie BS et al. | Melanoma and dietary lipids. | 1987 | Nutr Cancer | pmid:3110746 |
Setty BN et al. | 13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3113422 |
Nugteren DH and Kivits GA | Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. | 1987 | Biochim. Biophys. Acta | pmid:3113487 |
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Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
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Cardot P et al. | Essential fatty acid deficiency during pregnancy in the rat: influence of dietary carbohydrates. | 1987 | J. Nutr. | pmid:3116179 |
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Uotila P et al. | Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3116200 |
Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
Bomalaski JS et al. | Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. | 1987 | Biochem. Pharmacol. | pmid:3117063 |
Ludwig P et al. | A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes. | 1987 | Eur. J. Biochem. | pmid:3117544 |
Taylor AJ et al. | An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus. | 1987 | Clin. Chem. | pmid:3119255 |
Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |
Field EJ and Joyce G | Duchenne muscular dystrophy: do both parents contribute genetically to the disease? | 1987 | J. Neurol. Sci. | pmid:3126270 |
Hicks M et al. | Catalysis of lipid peroxidation by glucose and glycosylated collagen. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3126742 |
Chapkin RS et al. | Inability of murine peritoneal macrophages to convert linoleic acid into arachidonic acid. Evidence of chain elongation. | 1988 | J. Immunol. | pmid:3127464 |
Brasitus TA and Dudeja PK | Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. | 1988 | Biochim. Biophys. Acta | pmid:3128322 |
Nilsson A and Landin B | Metabolism of chylomicron arachidonic and linoleic acid in the rat. | 1988 | Biochim. Biophys. Acta | pmid:3128335 |
Cotter R et al. | Fatty acid profiles in response to soybean oil lipid emulsion infusions in essential fatty acid-deficient miniature swine. | 1988 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:3129587 |
Sauer LA and Dauchy RT | Identification of linoleic and arachidonic acids as the factors in hyperlipemic blood that increase [3H]thymidine incorporation in hepatoma 7288CTC perfused in situ. | 1988 | Cancer Res. | pmid:3130186 |
Albro PW et al. | Comparison of the effects of carbon tetrachloride and of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the disposition of linoleic acid in rat liver in vitro. | 1988 | Chem. Biol. Interact. | pmid:3135123 |
Rimola A et al. | Prostaglandin precursor fatty acids in cirrhosis with ascites: effect of linoleic acid infusion in functional renal failure. | 1988 | Clin. Sci. | pmid:3135142 |
Staats DA et al. | Effects of tocopherol depletion on the regional differences in adrenal microsomal lipid peroxidation and steroid metabolism. | 1988 | Endocrinology | pmid:3135177 |
Craven PA and DeRubertis FR | Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. | 1988 | Gastroenterology | pmid:3135225 |
Ghisolfi J et al. | Metabolic utilization of linoleic acid from fat emulsion in infants during total parenteral nutrition. | 1988 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:3138449 |
Nakagawa Y and Waku K | Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3142466 |
Clark RM | Lack of correlation between changes in the concentrations of linoleate and arachidonate in human milk relative to total milk lipid. | 1988 Nov-Dec | J. Pediatr. Gastroenterol. Nutr. | pmid:3143822 |
Shasby DM et al. | Oxidants and conductance of cultured epithelial cell monolayers: inositol phospholipid hydrolysis. | 1988 | Am. J. Physiol. | pmid:3144179 |
Das UN | Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144272 |
Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
MacKenzie LW et al. | Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. | 1988 | Am. J. Obstet. Gynecol. | pmid:3144917 |
Benadé AJ et al. | Plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined Vervet monkeys. | 1988 | Atherosclerosis | pmid:3145748 |
Wertz PW et al. | The composition of the ceramides from human stratum corneum and from comedones. | 1985 | J. Invest. Dermatol. | pmid:3158712 |
Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
Grant HW et al. | Dietary linoleic acid, gastric acid, and prostaglandin secretion. | 1988 | Gastroenterology | pmid:3162220 |
Schepp W et al. | Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage. | 1988 | Gastroenterology | pmid:3163660 |
Pschera H et al. | The influence of copper intrauterine device on fatty acid composition of cervical mucus lecithin. | 1988 | Contraception | pmid:3168451 |
Kurinami S et al. | Effects of polyunsaturated fatty acids and/or lecithin on the plasma concentrations of very low density lipoprotein-tryglyceride (VLDL) and ketone bodies in humans. | 1988 | Kurume Med J | pmid:3193745 |
Babin F et al. | Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. | 1988 | Ann. Nutr. Metab. | pmid:3195990 |
Hubbard NE et al. | Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin. | 1988 | Cancer Lett. | pmid:3203321 |
Parsons HG et al. | Supplemental calories improve essential fatty acid deficiency in cystic fibrosis patients. | 1988 | Pediatr. Res. | pmid:3211621 |
Solakivi T et al. | Plasma apolipoprotein B in middle-aged Finnish men. Evidence for a regional gradient of apo B and lack of negative correlation between apo B and dietary linoleate in hyperapobetalipoproteinemia. | 1988 | Atherosclerosis | pmid:3214459 |
Whitehead CC and Herron KM | Fatty acid requirements of breeding turkeys. | 1988 | Br. Poult. Sci. | pmid:3233502 |
De Deckere EA et al. | Effects of type and amount of dietary fat on rabbit and rat lymphocyte proliferation in vitro. | 1988 | J. Nutr. | pmid:3257261 |
Perez RV et al. | Dietary immunoregulation of transfusion-induced immunosuppression. | 1988 | Transplantation | pmid:3258077 |
Tiwari RK et al. | Influence of genotype on the phospholipid fatty acid composition of splenic T and B lymphocytes in MRL/MpJ-lpr/lpr mice. | 1988 | Immunol. Lett. | pmid:3258845 |
Cutts JL and Melnykovych G | Defective utilization of cholesterol esters from low-density lipoprotein in a human acute lymphoblastic leukemia T cell line. | 1988 | Biochim. Biophys. Acta | pmid:3260113 |
Bandyopadhyay GK et al. | Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2. | 1988 | J. Biol. Chem. | pmid:3286636 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
Wertz PW et al. | Essential fatty acids and epidermal integrity. | 1987 | Arch Dermatol | pmid:3310912 |
Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
Dormandy TL and Wickens DG | The experimental and clinical pathology of diene conjugation. | 1987 Nov-Dec | Chem. Phys. Lipids | pmid:3319233 |
Spector R | Fatty acid transport through the blood-brain barrier. | 1988 | J. Neurochem. | pmid:3335863 |
Casteels M et al. | Inhibition of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid oxidation and of bile acid secretion in rat liver by fatty acids. | 1988 | J. Biol. Chem. | pmid:3350807 |
Rafael J et al. | Effect of dietary linoleic acid and essential fatty acid deficiency on resting metabolism, nonshivering thermogenesis and brown adipose tissue in the rat. | 1988 | J. Nutr. | pmid:3367242 |
Simpson LO | The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis. | 1988 | Med. Hypotheses | pmid:3367811 |
Behrends W et al. | The glyoxysomal beta-oxidation system in cucumber seedlings: identification of enzymes required for the degradation of unsaturated fatty acids. | 1988 | Arch. Biochem. Biophys. | pmid:3369861 |
Slinger AJ and Isaac RE | Synthesis of apolar ecdysone esters by ovaries of the cockroach Periplaneta americana. | 1988 | Gen. Comp. Endocrinol. | pmid:3371652 |
Kawooya JK and Law JH | Role of lipophorin in lipid transport to the insect egg. | 1988 | J. Biol. Chem. | pmid:3379043 |
Bester R and Lochner A | Sarcolemmal phospholipid fatty acid composition and permeability. | 1988 | Biochim. Biophys. Acta | pmid:3382645 |
Asciutti-Moura LS et al. | Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. | 1988 | Am. J. Clin. Nutr. | pmid:3421207 |
Griffiths G et al. | Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). | 1988 | Biochem. J. | pmid:3421914 |
Watkins BA and Kratzer FH | Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. | 1987 | Poult. Sci. | pmid:3452223 |
Elliott GR et al. | Linoleic and dihomo-gamma-linolenic acids modulate granuloma growth and granuloma macrophage eicosanoid release. | 1986 | Eur. J. Pharmacol. | pmid:3460810 |
Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
Heleniak EP and Lamola SW | A new prostaglandin disturbance syndrome in schizophrenia: delta-6-pyroluria. | 1986 | Med. Hypotheses | pmid:3520252 |
Wan JM and Grimble RF | Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin. | 1987 | Clin. Sci. | pmid:3545648 |
Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |
Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
Griffin JF et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material. | 1987 | Clin. Chim. Acta | pmid:3568417 |
Tay SK et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells. | 1987 | Clin. Chim. Acta | pmid:3568418 |
Emken EA et al. | Metabolism of cis-12-octadecenoic acid and trans-9,trans-12-octadecadienoic acid and their influence on lipogenic enzyme activities in mouse liver. | 1987 | Biochim. Biophys. Acta | pmid:3580379 |
Arca M et al. | Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. | 1987 | Am. J. Clin. Nutr. | pmid:3604961 |
Hagve TA and Christophersen BO | Sex-related differences in desaturation and chain elongation of essential fatty acids studied in isolated rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3607076 |
Tilvis RS et al. | Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. | 1987 | Atherosclerosis | pmid:3619988 |
Dupont J | Essential fatty acids and prostaglandins. | 1987 | Prev Med | pmid:3628199 |
Steinberg WM et al. | Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency. | 1987 | Pancreas | pmid:3628223 |
Kromhout D et al. | Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol. | 1987 | Atherosclerosis | pmid:3632757 |
Berlin E et al. | Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men. | 1987 | Atherosclerosis | pmid:3632760 |