Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Lactose Intolerance D007787 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Melanosis D008548 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Otitis Externa D010032 8 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Glucose Intolerance D018149 13 associated lipids
Alopecia D000505 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Tuberculosis D014376 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Birth Weight D001724 23 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Kidney Diseases D007674 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Diseases D008107 31 associated lipids
Heart Failure D006333 36 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Fatty Liver D005234 48 associated lipids
Precancerous Conditions D011230 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Pain D010146 64 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Colitis D003092 69 associated lipids
Coronary Disease D003327 70 associated lipids
Leukemia D007938 74 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Kim SY et al. S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. 2013 Mol. Cells pmid:24046187
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Mabalirajan U et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. 2013 Sci Rep pmid:23443229
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Khan AA et al. Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. 2013 Nanomedicine (Lond) pmid:23311988
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Gousiadou C et al. Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. 2013 J Enzyme Inhib Med Chem pmid:22630074
Bin Q et al. The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. 2013 Lipids pmid:23065354
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Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
D'Angeli S et al. Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. 2013 New Phytol. pmid:23078289
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Mujtaba SF et al. Singlet oxygen mediated apoptosis by anthrone involving lysosomes and mitochondria at ambient UV exposure. 2013 J. Hazard. Mater. pmid:23542321
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Hein LK et al. Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease. 2013 J. Lipid Res. pmid:23564732
Zhao Y et al. Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. 2013 PLoS ONE pmid:23565210
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
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Ramirez AM et al. A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. 2013 Lipids pmid:23893337
Daud AZ et al. The trans fatty acid content in human milk and its association with maternal diet among lactating mothers in Malaysia. 2013 Asia Pac J Clin Nutr pmid:23945414
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Kummerow FA et al. Effects of trans fats on prostacyclin production. 2013 Scand. Cardiovasc. J. pmid:24228623
Herrera-Meza MS et al. Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. 2013 Int J Food Sci Nutr pmid:23360131
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Hashim A et al. Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study. 2013 Biomed Res Int pmid:23957001
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Xia Q et al. Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. 2013 Food Chem. Toxicol. pmid:23867545
Le Maux S et al. Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect. 2013 Food Chem pmid:23870962
Aladedunye F and Przybylski R Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content. 2013 Food Chem pmid:23870970
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
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Ngakegni-Limbili AC et al. Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. 2013 J. Sci. Food Agric. pmid:22692978
De Weirdt R et al. A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. 2013 Benef Microbes pmid:24311313
Li XP et al. Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. 2013 Lipids pmid:23341188
Okada Y et al. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. 2013 Clin. Exp. Immunol. pmid:24028683
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Osuji GO et al. Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. 2012 Appl. Biochem. Biotechnol. pmid:22918723
Kim YS et al. In vitro protective effects of Thymus quinquecostatus Celak extracts on t-BHP-induced cell damage through antioxidant activity. 2012 Food Chem. Toxicol. pmid:22921350
Le Maux S et al. β-Lactoglobulin as a molecular carrier of linoleate: characterization and effects on intestinal epithelial cells in vitro. 2012 J. Agric. Food Chem. pmid:22924475
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Chen MH and Nelson EB Microbial-induced carbon competition in the spermosphere leads to pathogen and disease suppression in a municipal biosolids compost. 2012 Phytopathology pmid:22352306
He M et al. Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression. 2012 J. Dairy Sci. pmid:22365227
Castro LF et al. Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. 2012 PLoS ONE pmid:22384110
Mulligan CM et al. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. 2012 Cardiovasc. Res. pmid:22411972
Gull J et al. Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. 2012 Molecules pmid:22418924