Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang L et al. | [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. | 2010 | Sheng Li Xue Bao | pmid:21170499 |
| Maia MR et al. | Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens. | 2010 | BMC Microbiol. | pmid:20167098 |
| Hirai S et al. | Loss of sense transgene-induced post-transcriptional gene silencing by sequential introduction of the same transgene sequences in tobacco. | 2010 | FEBS J. | pmid:20180844 |
| Thornhill JA et al. | Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration. | 2010 | Parasitology | pmid:20128942 |
| Combet E et al. | Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20112267 |
| Castellanos P et al. | Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. | 2010 | Reprod. Toxicol. | pmid:20096347 |
| Coyral-Castel S et al. | Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells. | 2010 | Domest. Anim. Endocrinol. | pmid:20097509 |
| Nakamura T et al. | Excessive fat restriction might promote the recurrence of colorectal tumors. | 2010 | Nutr Cancer | pmid:20099189 |
| Beevi SS et al. | Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. | 2010 | Plant Foods Hum Nutr | pmid:20072818 |
| Privé F et al. | Temperature and duration of heating of sunflower oil affect ruminal biohydrogenation of linoleic acid in vitro. | 2010 | J. Dairy Sci. | pmid:20105542 |
| Ivanova L et al. | Phomenins and fatty acids from Alternaria infectoria. | 2010 | Toxicon | pmid:20060014 |
| Li Y et al. | Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats. | 2010 | Br. J. Nutr. | pmid:20420751 |
| Edwards SJ et al. | Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase. | 2010 | J Phys Chem B | pmid:20423074 |
| Patwardhan AM et al. | Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. | 2010 | J. Clin. Invest. | pmid:20424317 |
| Lábaque MC et al. | Effect of age and body weight of Greater Rhea (Rhea americana) females on egg number, size and composition. | 2010 | Br. Poult. Sci. | pmid:21161792 |
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| Deiana M et al. | Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. | 2010 | Food Chem. Toxicol. | pmid:20691238 |
| Rodrigues HG et al. | Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats. | 2010 | Lipids | pmid:20730605 |
| Tel G et al. | Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities. | 2010 | Food Chem. Toxicol. | pmid:20732375 |
| Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
| Gutiérrez-Correa J | Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. | 2010 | Free Radic. Res. | pmid:20815787 |
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| Bolton B and Halpern BP | Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids. | 2010 | Chem. Senses | pmid:20100787 |
| Lu XF et al. | Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. | 2010 | J Zhejiang Univ Sci B | pmid:21121070 |
| Luo H et al. | The In vitro antioxidant properties of chinese highland lichens. | 2010 | J. Microbiol. Biotechnol. | pmid:21124057 |
| Olszewska MA et al. | Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. | 2010 | Molecules | pmid:21127463 |
| Gotoh N et al. | Highly unsaturated fatty acid might act as an antioxidant in emulsion system oxidized by azo compound. | 2010 | J Oleo Sci | pmid:21099140 |
| Wu TC et al. | Fatty acid composition of Taiwanese human milk. | 2010 | J Chin Med Assoc | pmid:21093826 |
| Safarinejad MR et al. | Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men. | 2010 | Clin Nutr | pmid:19666200 |
| Demir AS and Talpur FN | Chemoenzymatic conversion of linoleic acid into conjugated linoleic acid. | 2010 | J. Agric. Food Chem. | pmid:20058923 |
| Duckett SK and Gillis MH | Effects of oil source and fish oil addition on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. | 2010 | J. Anim. Sci. | pmid:20348369 |
| Georgiadi A et al. | Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. | 2010 | Circ. Res. | pmid:20378851 |
| Zulkifli RM et al. | Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. | 2010 | J. Anim. Sci. | pmid:20382866 |
| DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
| Marei WF et al. | Impact of linoleic acid on bovine oocyte maturation and embryo development. | 2010 | Reproduction | pmid:20215338 |
| Khiaosa-Ard R et al. | Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. | 2010 | J. Dairy Res. | pmid:20482940 |
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| Cannata S et al. | Effect of visual marbling on sensory properties and quality traits of pork loin. | 2010 | Meat Sci. | pmid:20416803 |
| Macouzet M et al. | Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus. | 2010 | Appl. Microbiol. Biotechnol. | pmid:20461509 |
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| Alloatti A et al. | Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. | 2010 | PLoS ONE | pmid:21151902 |
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| Yu C et al. | Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19648018 |
| Kawakami Y et al. | Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. | 2009 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19457650 |
| Parnas M et al. | Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. | 2009 May-Jun | Channels (Austin) | pmid:19535910 |
| Zeng Z et al. | Identification of lactic acid bacterial strains with high conjugated linoleic acid-producing ability from natural sauerkraut fermentations. | 2009 May-Jul | J. Food Sci. | pmid:19490332 |