Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Macouzet M et al. | Production of conjugated linoleic acid by probiotic Lactobacillus acidophilus La-5. | 2009 | J. Appl. Microbiol. | pmid:19228257 |
| Pacini G et al. | Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19211728 |
| Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
| Calder PC | Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? | 2009 | Br. J. Nutr. | pmid:19166631 |
| Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
| Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
| Niisuke K et al. | Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. | 2009 | J. Lipid Res. | pmid:19244216 |
| Parnas M et al. | Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. | 2009 | J. Neurosci. | pmid:19244513 |
| Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
| MartÃnez-Force E et al. | Influence of specific fatty acids on the asymmetric distribution of saturated fatty acids in sunflower (Helianthus annuus L.) triacylglycerols. | 2009 | J. Agric. Food Chem. | pmid:19166295 |
| Zhao Z et al. | Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. | 2009 | Biomacromolecules | pmid:19175304 |
| Eriksson S et al. | Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. | 2009 | Br. J. Nutr. | pmid:19175947 |
| Kim MH et al. | Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. | 2009 | Cell. Physiol. Biochem. | pmid:19255500 |
| Takata Y et al. | Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. | 2009 | Cancer Causes Control | pmid:19255861 |
| Guillén N et al. | Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. | 2009 | Physiol. Genomics | pmid:19258494 |
| Gülçin I | Antioxidant activity of L-adrenaline: a structure-activity insight. | 2009 | Chem. Biol. Interact. | pmid:18929549 |
| Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
| de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
| Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
| RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
| Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
| Taha AY et al. | Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. | 2009 | Epilepsia | pmid:18657173 |
| Stratford JM and Contreras RJ | Saliva and other taste stimuli are important for gustatory processing of linoleic acid. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19692663 |
| Choi NJ et al. | Characterizations of environmental factors in conjugated linoleic acid production by mixed rumen bacteria. | 2009 | J. Agric. Food Chem. | pmid:19754193 |
| Chow CK | Dietary beta-tocopherol and serum concentrations of sex hormone-binding globulin. | 2009 | J. Nutr. | pmid:19710160 |
| Roche M et al. | Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. | 2009 | Biochim. Biophys. Acta | pmid:19714864 |
| Pianaro A et al. | Stingless bees: chemical differences and potential functions in Nannotrigona testaceicornis and Plebeia droryana males and workers. | 2009 | J. Chem. Ecol. | pmid:19730955 |
| de Castro J et al. | Platelet linoleic acid is a potential biomarker of advanced non-small cell lung cancer. | 2009 | Exp. Mol. Pathol. | pmid:19733167 |
| Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
| Radunz AE et al. | Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. | 2009 | J. Anim. Sci. | pmid:19717771 |
| Taylor WA and Hatch GM | Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). | 2009 | J. Biol. Chem. | pmid:19737925 |
| Iwamoto N et al. | Antioxidative capacities of durum wheat flour and its components on linoleic acid. | 2009 | J Oleo Sci | pmid:19745581 |
| Queirós B et al. | In search of synergistic effects in antioxidant capacity of combined edible mushrooms. | 2009 | Int J Food Sci Nutr | pmid:19746297 |
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| Wecksler AT et al. | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. | 2009 | Bioorg. Med. Chem. | pmid:19716306 |
| Li Z et al. | Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. | 2009 | Chem. Phys. Lipids | pmid:19146841 |
| Tribole E | What happened to do no harm? The issue of dietary omega-6 fatty acids. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147337 |
| Ramsden CE et al. | Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147338 |
| Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
| Robinson NJ et al. | A potential role for free fatty acids in the pathogenesis of preeclampsia. | 2009 | J. Hypertens. | pmid:19462499 |
| Dauchy RT et al. | Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. | 2009 | J. Pineal Res. | pmid:19486272 |
| Yano M et al. | Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. | 2009 | Hepatology | pmid:19492433 |
| Zhang M et al. | Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. | 2009 | Chem. Biol. Interact. | pmid:19497410 |
| Finn RD et al. | Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | 2009 | Biochem. J. | pmid:18778245 |
| Cheong SJ et al. | Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. | 2009 | Int J Pharm | pmid:19429277 |
| Fang IM et al. | Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. | 2009 | Mol Nutr Food Res | pmid:19437483 |
| Mimoun M et al. | Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. | 2009 | J. Nutr. | pmid:19828687 |
| Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
| Grossmann ME et al. | Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. | 2009 | Cancer Prev Res (Phila) | pmid:19789297 |