Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wang L et al. | [Effects of linoleic acid on intracellular calcium concentration in primarily cultured rat pancreatic β-cells and underlying mechanism]. | 2010 | Sheng Li Xue Bao | pmid:21170499 |
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Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
Liu Q et al. | Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). | 2013 | Theor. Appl. Genet. | pmid:23695179 |
Rezzonico E et al. | Level of accumulation of epoxy fatty acid in Arabidopsis thaliana expressing a linoleic acid delta12-epoxygenase is influenced by the availability of the substrate linoleic acid. | 2004 | Theor. Appl. Genet. | pmid:15221145 |
Klein J et al. | Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. | 1999 | Ther Drug Monit | pmid:10604826 |
Laowtammathron C et al. | Factors affecting cryosurvival of nuclear-transferred bovine and swamp buffalo blastocysts: effects of hatching stage, linoleic acid-albumin in IVC medium and Ficoll supplementation to vitrification solution. | 2005 | Theriogenology | pmid:16125561 |
Khalil WA et al. | Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. | 2013 | Theriogenology | pmid:23683689 |
Carro M et al. | Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. | 2013 | Theriogenology | pmid:23273433 |
Tominaga K et al. | Effect of lipid polarization by centrifugation at different developmental stages on post-thaw survival of bovine in vitro produced 16-cell embryos. | 2000 | Theriogenology | pmid:10883852 |
Kemp B et al. | Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. | 1998 | Theriogenology | pmid:10732036 |
Hochi S et al. | Effect of linoleic acid-albumin in the culture medium on freezing sensitivity of in vitro-produced bovine morulae. | 1999 | Theriogenology | pmid:10734383 |
Gigli I et al. | Effects of oxygen tension and supplements to the culture medium on activation and development of bovine follicles in vitro. | 2006 | Theriogenology | pmid:16442155 |
Colazo MG et al. | Fertility following fixed-time AI in CIDR-treated beef heifers given GnRH or estradiol cypionate and fed diets supplemented with flax seed or sunflower seed. | 2004 | Theriogenology | pmid:15036999 |