Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
| Sell JL et al. | Metabolizable energy value of conjugated linoleic acid for broiler chicks and laying hens. | 2001 | Poult. Sci. | pmid:11233010 |
| Du M et al. | Volatile profiles and lipid oxidation of irradiated cooked chicken meat from laying hens fed diets containing conjugated linoleic acid. | 2001 | Poult. Sci. | pmid:11233015 |
| Sijben JW et al. | Dietary linoleic acid divergently affects immune responsiveness of growing layer hens. | 2000 | Poult. Sci. | pmid:10947178 |
| Keshavarz K | Further investigations on the effect of dietary manipulations of nutrients on early egg weight. | 1995 | Poult. Sci. | pmid:7899214 |
| Latour MA et al. | Effects of conjugated linoleic acid. 1. Fatty acid modification of yolks and neonatal fatty acid metabolism. | 2000 | Poult. Sci. | pmid:10875761 |
| Latour MA et al. | Effects of conjugated linoleic acid. 2. Embryonic and neonatal growth and circulating lipids. | 2000 | Poult. Sci. | pmid:10875762 |
| Vilchez C et al. | Research note: eggshell quality in Japanese quail fed different fatty acids. | 1992 | Poult. Sci. | pmid:1409241 |
| Grobas S et al. | Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. | 1999 | Poult. Sci. | pmid:10560827 |
| Du M et al. | Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. | 1999 | Poult. Sci. | pmid:10560841 |
| Chamruspollert M and Sell JL | Transfer of dietary conjugated linoleic acid to egg yolks of chickens. | 1999 | Poult. Sci. | pmid:10472840 |
| Peebles ED et al. | Effects of dietary fat type and level on broiler breeder performance. | 2000 | Poult. Sci. | pmid:10824949 |
| Ahn DU et al. | Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. | 1999 | Poult. Sci. | pmid:10438141 |
| Watkins BA and Kratzer FH | Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. | 1987 | Poult. Sci. | pmid:3452223 |
| Sammon AM | Dietary linoleic acid, immune inhibition and disease. | 1999 | Postgrad Med J | pmid:10448487 |
| Adiguzel A et al. | Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria. | 2009 | Pol. J. Microbiol. | pmid:19469289 |
| Padayachee T et al. | The Detection of Metabolite-Mediated Gene Module Co-Expression Using Multivariate Linear Models. | 2016 | PLoS ONE | pmid:26918614 |
| Harris WS et al. | Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study. | 2016 | PLoS ONE | pmid:26881936 |
| Phan CW et al. | Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism. | 2015 | PLoS ONE | pmid:26565787 |
| Emery JA et al. | Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. | 2013 | PLoS ONE | pmid:23460861 |
| Gouveia-Figueira S et al. | Serum levels of oxylipins in achilles tendinopathy: an exploratory study. | 2015 | PLoS ONE | pmid:25875933 |
| Chen S et al. | Profiling of volatile compounds and associated gene expression and enzyme activity during fruit development in two cucumber cultivars. | 2015 | PLoS ONE | pmid:25799542 |
| Manosalva C et al. | Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. | 2015 | PLoS ONE | pmid:25790461 |
| Xing J et al. | Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods. | 2015 | PLoS ONE | pmid:25789875 |
| Saccenti E et al. | Strategies for individual phenotyping of linoleic and arachidonic acid metabolism using an oral glucose tolerance test. | 2015 | PLoS ONE | pmid:25786212 |
| Ciepiela P et al. | Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting. | 2015 | PLoS ONE | pmid:25763593 |
| Ruiz M et al. | A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis. | 2012 | PLoS ONE | pmid:23056435 |
| van Schalkwijk DB et al. | Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation. | 2014 | PLoS ONE | pmid:25049048 |
| Fukuda S et al. | Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. | 2009 | PLoS ONE | pmid:19287504 |
| Mesti T et al. | Metabolic impact of anti-angiogenic agents on U87 glioma cells. | 2014 | PLoS ONE | pmid:24922514 |
| Woyda-Ploszczyca AM and Jarmuszkiewicz W | Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. | 2014 | PLoS ONE | pmid:24904988 |
| Troche JR et al. | Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers. | 2016 | PLoS ONE | pmid:26967509 |
| BuÄek A et al. | Δ12-Fatty acid desaturase from Candida parapsilosis is a multifunctional desaturase producing a range of polyunsaturated and hydroxylated fatty acids. | 2014 | PLoS ONE | pmid:24681902 |
| Prasad A and PospÃÅ¡il P | Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. | 2011 | PLoS ONE | pmid:21799835 |
| Zhao Y et al. | Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. | 2013 | PLoS ONE | pmid:23565210 |
| Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
| de Goede J et al. | N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. | 2013 | PLoS ONE | pmid:23741290 |
| Noel JT et al. | Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. | 2010 | PLoS ONE | pmid:20824208 |
| Zhang HM et al. | Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. | 2009 | PLoS ONE | pmid:19557129 |
| Tarnopolsky M et al. | Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. | 2007 | PLoS ONE | pmid:17912368 |
| Abdoul-Azize S et al. | Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus. | 2013 | PLoS ONE | pmid:23936306 |
| Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
| Kenny JG et al. | Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. | 2013 | PLoS ONE | pmid:23861785 |
| Sengupta N et al. | Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin allocation by dietary lipids and environmental toxicants. | 2017 | PLoS ONE | pmid:28542405 |
| Benbrook CM et al. | Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. | 2013 | PLoS ONE | pmid:24349282 |
| Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
| Zhao A et al. | Use of real-time cellular analysis and Plackett-Burman design to develop the serum-free media for PC-3 prostate cancer cells. | 2017 | PLoS ONE | pmid:28945791 |
| Sinanoglou VJ et al. | Factors affecting human colostrum fatty acid profile: A case study. | 2017 | PLoS ONE | pmid:28410426 |
| Inzaugarat ME et al. | New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans. | 2017 | PLoS ONE | pmid:28257515 |
| Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
| Sisignano M et al. | Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. | 2013 | PLoS ONE | pmid:24349046 |
| Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
| Zhang YH et al. | The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life. | 2016 | PLoS ONE | pmid:27780226 |
| Rodrigues HG et al. | Oral Administration of Linoleic Acid Induces New Vessel Formation and Improves Skin Wound Healing in Diabetic Rats. | 2016 | PLoS ONE | pmid:27764229 |
| Paulsen SJ et al. | Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. | 2014 | PLoS ONE | pmid:24520357 |
| Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
| Liu G et al. | Biotype Characterization, Developmental Profiling, Insecticide Response and Binding Property of Bemisia tabaci Chemosensory Proteins: Role of CSP in Insect Defense. | 2016 | PLoS ONE | pmid:27167733 |
| Jumbe T et al. | Whole Blood Levels of the n-6 Essential Fatty Acid Linoleic Acid Are Inversely Associated with Stunting in 2-to-6 Year Old Tanzanian Children: A Cross-Sectional Study. | 2016 | PLoS ONE | pmid:27137223 |
| Nardi F et al. | Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. | 2014 | PLoS ONE | pmid:24632852 |
| Alloatti A et al. | Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target. | 2010 | PLoS ONE | pmid:21151902 |
| Abdullah BM et al. | Polyesters Based on Linoleic Acid for Biolubricant Basestocks: Low-Temperature, Tribological and Rheological Properties. | 2016 | PLoS ONE | pmid:27008312 |
| Ishida K and Jolly ER | Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion. | 2016 | PLoS Negl Trop Dis | pmid:27611863 |
| Liu JH et al. | Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. | 1998 | Planta Med. | pmid:9741298 |
| Haraguchi H et al. | Antioxidative action of diterpenoids from Podocarpus nagi. | 1997 | Planta Med. | pmid:9225601 |
| Su BN et al. | Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. | 2002 | Planta Med. | pmid:12494342 |
| Sewram V et al. | Supercritical fluid extraction and analysis of compounds from Clivia miniata for uterotonic activity. | 2001 | Planta Med. | pmid:11488461 |
| Malhotra S et al. | Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. | 2009 | Planta Med. | pmid:19031367 |
| Hou WC et al. | Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro. | 2002 | Planta Med. | pmid:12494332 |
| AbouZid S and Orihara Y | Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. | 2007 | Planta Med. | pmid:17973205 |
| Hong CY et al. | Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. | 1993 | Planta Med. | pmid:8372148 |
| Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
| de Virville JD et al. | Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. | 2008 | Planta | pmid:18663470 |
| Smith MA et al. | Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana. | 2003 | Planta | pmid:14520576 |
| Quintana N et al. | Phytotoxic compounds from roots of Centaurea diffusa Lam. | 2009 | Plant Signal Behav | pmid:19568334 |
| Kang J et al. | Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa. | 2011 | Plant Physiol. Biochem. | pmid:21215650 |
| Hofmann E and Pollmann S | Molecular mechanism of enzymatic allene oxide cyclization in plants. | 2008 | Plant Physiol. Biochem. | pmid:18272375 |
| Zhang D et al. | Identification and expression of a new delta-12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. | 2009 | Plant Physiol. Biochem. | pmid:19217793 |
| Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
| Lorenzi V et al. | Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). | 2006 Jul-Sep | Plant Physiol. Biochem. | pmid:17011785 |
| Yu C et al. | Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19648018 |
| Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
| Fraser TC et al. | Expression of the Isochrysis C18-delta9 polyunsaturated fatty acid specific elongase component alters Arabidopsis glycerolipid profiles. | 2004 | Plant Physiol. | pmid:15173563 |
| Woodfield HK et al. | Spatial and Temporal Mapping of Key Lipid Species in Brassica napus Seeds. | 2017 | Plant Physiol. | pmid:28188274 |
| Cahoon EB et al. | Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. | 2002 | Plant Physiol. | pmid:11842164 |
| DomÃnguez T et al. | Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. | 2010 | Plant Physiol. | pmid:20382895 |
| Forster C et al. | Molecular analysis of a null mutant for pea (Pisum sativum L.) seed lipoxygenase-2. | 1999 | Plant Mol. Biol. | pmid:10380807 |
| Girgih AT et al. | Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. | 2013 | Plant Foods Hum Nutr | pmid:23417711 |
| Beevi SS et al. | Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. | 2010 | Plant Foods Hum Nutr | pmid:20072818 |
| Freiberger CE et al. | Nutrient content of the edible leaves of seven wild plants from Niger. | 1998 | Plant Foods Hum Nutr | pmid:10890758 |
| Valdez-Morales M et al. | Phenolic Compounds, Antioxidant Activity and Lipid Profile of Huitlacoche Mushroom (Ustilago maydis) Produced in Several Maize Genotypes at Different Stages of Development. | 2016 | Plant Foods Hum Nutr | pmid:27605221 |
| Rahamatalla AB et al. | Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. | 2001 | Plant Foods Hum Nutr | pmid:11678443 |
| Rao MS et al. | Yield, protein, and oil quality of soybean genotypes selected for tofu production. | 1998 | Plant Foods Hum Nutr | pmid:9950085 |
| Saubeau G et al. | Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. | 2013 | Plant Cell Rep. | pmid:23479199 |
| Laus MN et al. | Plant inner membrane anion channel (PIMAC) function in plant mitochondria. | 2008 | Plant Cell Physiol. | pmid:18511459 |
| Runyon JB et al. | Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato. | 2010 | Plant Cell Environ. | pmid:19930126 |
| Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
| Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
| Ito T et al. | The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. | 2007 | Plant Cell | pmid:17981996 |
| Huang FC and Schwab W | Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. | 2012 | Plant Biotechnol. J. | pmid:22967031 |
| Hover CG and Kulkarni AP | Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid. | 2000 | Placenta | pmid:10985967 |