Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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van de Sandt JJ et al. | Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. | 1995 | Fundam Appl Toxicol | pmid:7601324 |
Kurushima H et al. | Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. | 1995 | Atherosclerosis | pmid:7605390 |
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Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
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van der Heijdt LM et al. | Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. | 1995 | Eur. J. Biochem. | pmid:7628469 |
Chen CC and Chen CS | Brugia pahangi: effects of melanization on the uptake of nutrients by microfilariae in vitro. | 1995 | Exp. Parasitol. | pmid:7628569 |
Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
Guo L et al. | Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. | 1995 | Free Radic. Biol. Med. | pmid:7628726 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
Appel MJ and Woutersen RA | Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. | 1995 | Cancer Lett. | pmid:7634246 |
Rao GN et al. | Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. | 1995 | J. Clin. Invest. | pmid:7635978 |
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Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Khan MF et al. | Hematopoietic toxicity of linoleic acid anilide: importance of aniline. | 1995 | Fundam Appl Toxicol | pmid:7665006 |
Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |
Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
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Angerman-Stewart JA et al. | Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. | 1995 | Arch. Biochem. Biophys. | pmid:7733666 |
Campbell FM et al. | Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733952 |
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López-Nicolás JM et al. | Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. | 1995 | Biochem. J. | pmid:7755559 |
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Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
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Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
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Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
Fuhrman B et al. | Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. | 1994 | Atherosclerosis | pmid:7840815 |
Kvilekval K et al. | Fatty acids as determinants of triglyceride and cholesteryl ester synthesis by isolated hepatocytes: kinetics as a function of various fatty acids. | 1994 | J. Lipid Res. | pmid:7852855 |
Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
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Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
Bulan EJ et al. | Immature maxi-K channels exhibit heterogeneous properties in the embryonic rat telencephalon. | 1994 | Dev. Neurosci. | pmid:7867514 |