Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bae WK et al. | Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer. | 2013 | Biomaterials | pmid:23174142 |
McGowan MM et al. | A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. | 2013 | Breast Cancer Res. Treat. | pmid:23417336 |
Mabalirajan U et al. | Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. | 2013 | Sci Rep | pmid:23443229 |
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Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
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Shen W et al. | Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. | 2013 | J. Lipid Res. | pmid:23401602 |
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Bartók T et al. | ESI-MS and MS/MS identification of the first ceramide analogues of fumonisin B₠mycotoxin from a Fusarium verticillioides culture following RP-HPLC separation. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23837460 |
Song Y et al. | Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members. | 2013 | Lipids Health Dis | pmid:23879935 |
Cao AH et al. | Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). | 2013 | Brain Res. | pmid:23811335 |
Wei J et al. | Linoleic acid attenuates endothelium-derived relaxing factor production by suppressing cAMP-hydrolyzing phosphodiesterase activity. | 2013 | Circ. J. | pmid:23883876 |
Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
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Falavigna C et al. | Fatty acid esters of fumonisins: first evidence of their presence in maize. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23819788 |
Zhao X et al. | Analysis of fatty acids and phytosterols in ethanol extracts of Nelumbo nucifera seeds and rhizomes by GC-MS. | 2013 | J. Agric. Food Chem. | pmid:23742045 |
Giua L et al. | Oxidative modifications of conjugated and unconjugated linoleic acid during heating. | 2013 | Food Chem | pmid:23692753 |
Liu Q et al. | Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). | 2013 | Theor. Appl. Genet. | pmid:23695179 |
Hand KV et al. | Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells. | 2013 | Eur J Nutr | pmid:22926626 |
Kälber T et al. | Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. | 2013 | J. Dairy Res. | pmid:23253429 |
Gage SH et al. | Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. | 2013 | Langmuir | pmid:23234434 |
Li A et al. | Thermally induced isomerization of linoleic acid in soybean oil. | 2013 | Chem. Phys. Lipids | pmid:23261796 |
Mena J et al. | Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. | 2013 | Vet. Immunol. Immunopathol. | pmid:23267746 |
Ramsden CE et al. | Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. | 2013 | BMJ | pmid:23386268 |
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Benjamin S et al. | Conjugated linoleic acid isomers and their precursor fatty acids regulate peroxisome proliferator-activated receptor subtypes and major peroxisome proliferator responsive element-bearing target genes in HepG2 cell model. | 2013 | J Zhejiang Univ Sci B | pmid:23365010 |
Harris WS et al. | Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375840 |
Chiou TY et al. | Characteristics and antioxidative ability of defatted rice bran extracts obtained using several extractants under subcritical conditions. | 2013 | J Oleo Sci | pmid:23357811 |
Fijlstra M et al. | Reduced absorption of long-chain fatty acids during methotrexate-induced gastrointestinal mucositis in the rat. | 2013 | Clin Nutr | pmid:23102689 |
Warstedt K and Duchén K | Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. | 2013 | Eur J Nutr | pmid:22584414 |
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Gousiadou C et al. | Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. | 2013 | J Enzyme Inhib Med Chem | pmid:22630074 |
McPherson PA et al. | Mechanism for the enhanced peroxidation of linoleic acid by a titanium dioxide/hypochlorite system. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23178466 |
Serna-Marquez N et al. | Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. | 2013 | Cell Oncol (Dordr) | pmid:23179791 |
Gámez-Meza N et al. | Chemical characterisation of kernels, kernel meals and oils from Jatropha cordata and Jatropha cardiophylla seeds. | 2013 | J. Sci. Food Agric. | pmid:23180465 |
Toral PG et al. | Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. | 2013 | J. Dairy Sci. | pmid:23164228 |
Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
Fedor DM et al. | The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. | 2013 | Metab Syndr Relat Disord | pmid:23170930 |
Ogata F et al. | Study on analysis of waste edible oil with deterioration and removal of acid value, carbonyl value, and free fatty acid by a food additive (calcium silicate). | 2013 | J Oleo Sci | pmid:23391535 |
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Chodok P et al. | Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23702573 |
Benjakul S et al. | Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems. | 2013 | Food Sci Technol Int | pmid:23729420 |
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Ndhlala AR et al. | Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. | 2013 | Molecules | pmid:23377133 |
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Abdoul-Azize S et al. | Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus. | 2013 | PLoS ONE | pmid:23936306 |
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Stelzleni AM et al. | Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles. | 2013 | J. Anim. Sci. | pmid:23893987 |
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Cvetković Z et al. | Distribution of plasma fatty acids is associated with response to chemotherapy in non-Hodgkin's lymphoma patients. | 2013 | Med. Oncol. | pmid:24085546 |
Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
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Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
Green DP et al. | Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. | 2013 | Pain | pmid:23891895 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Ruparel S et al. | Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. | 2013 | Pain | pmid:23867730 |
Yang Y and McClements DJ | Vitamin E and vitamin E acetate solubilization in mixed micelles: physicochemical basis of bioaccessibility. | 2013 | J Colloid Interface Sci | pmid:23768725 |
Okada Y et al. | Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. | 2013 | Clin. Exp. Immunol. | pmid:24028683 |
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Vukašinović EL et al. | Diapause induces changes in the composition and biophysical properties of lipids in larvae of the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23701990 |
Layek B and Singh J | Cell penetrating peptide conjugated polymeric micelles as a high performance versatile nonviral gene carrier. | 2013 | Biomacromolecules | pmid:24083483 |
Luo X et al. | Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. | 2013 | Mol. Biol. Rep. | pmid:24062071 |
Peters BD et al. | Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis. | 2013 | Schizophr Bull | pmid:22927668 |
Yamagishi K et al. | Plasma fatty acid composition and incident ischemic stroke in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. | 2013 | Cerebrovasc. Dis. | pmid:23920478 |