Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Cogo PE et al. | Endogenous surfactant metabolism in critically ill infants measured with stable isotope labeled fatty acids. | 1999 | Pediatr. Res. | pmid:10022597 |
Umezawa M et al. | High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. | 1999 | J. Nutr. | pmid:10024623 |
Cunnane SC | The long history of essential fatty acids but belated knowledge about linoleate deficiency per se: a paradox. | 1999 | J. Nutr. | pmid:10024625 |
Aki T et al. | Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10049752 |
Avery SV et al. | Stimulation of strontium accumulation in linoleate-enriched Saccharomyces cerevisiae is a result of reduced Sr2+ efflux. | 1999 | Appl. Environ. Microbiol. | pmid:10049882 |
Josyula S et al. | Inhibition of DNA adduct formation of PhIP in female F344 rats by dietary conjugated linoleic acid. | 1998 | Nutr Cancer | pmid:10050262 |
Josyula S and Schut HA | Effects of dietary conjugated linoleic acid on DNA adduct formation of PhIP and IQ after bolus administration to female F344 rats. | 1998 | Nutr Cancer | pmid:10050263 |
Jussila M et al. | Separation of linoleic acid oxidation products by micellar electrokinetic capillary chromatography and nonaqueous capillary electrophoresis. | 1999 | Electrophoresis | pmid:10065966 |
Rukkwamsuk T et al. | Hepatic fatty acid composition in periparturient dairy cows with fatty liver induced by intake of a high energy diet in the dry period. | 1999 | J. Dairy Sci. | pmid:10068949 |
Dhiman TR et al. | Conjugated linoleic acid content of milk and cheese from cows fed extruded oilseeds. | 1999 | J. Dairy Sci. | pmid:10068962 |
Chancharme L et al. | Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10073990 |
Olsson U et al. | Fatty acids modulate the composition of extracellular matrix in cultured human arterial smooth muscle cells by altering the expression of genes for proteoglycan core proteins. | 1999 | Diabetes | pmid:10078565 |
Brodie AE et al. | Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. | 1999 | J. Nutr. | pmid:10082762 |
Galli A et al. | High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. | 1999 | Hepatology | pmid:10094961 |
Stewart JM et al. | Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals. | 1998 | Biochem. Cell Biol. | pmid:10099779 |
Augé N et al. | Uptake of 13-hydroperoxylinoleic acid by cultured cells. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10195919 |
Jayawickreme SP et al. | Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. | 1999 | Am. J. Physiol. | pmid:10198357 |
DeLany JP et al. | Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. | 1999 | Am. J. Physiol. | pmid:10198400 |
Bergamini S et al. | Prooxidant activity of ferrioxamine in isolated rat hepatocytes and linoleic acid micelles. | 1999 | Chem. Res. Toxicol. | pmid:10207126 |