Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bates D | Lipids and multiple sclerosis. | 1989 | Biochem. Soc. Trans. | pmid:2546837 |
| Tchervenkov JI et al. | The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. | 1989 | Transplantation | pmid:2643225 |
| Balakrishnan A et al. | Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas. | 1989 | Cancer Res. | pmid:2643465 |
| Mcgregor L et al. | Effects of dietary linoleic acid and gamma linolenic acid on platelets of patients with multiple sclerosis. | 1989 | Acta Neurol. Scand. | pmid:2782038 |
| Perez RV et al. | Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid. | 1989 | Transplantation | pmid:2660353 |
| Clouet P et al. | Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. | 1989 | Biochem. J. | pmid:2597132 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| Madison KC et al. | Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. | 1989 | J. Invest. Dermatol. | pmid:2473131 |
| Grossi IM et al. | Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. | 1989 | Cancer Res. | pmid:2492204 |
| Anderson GJ and Connor WE | On the demonstration of omega-3 essential-fatty-acid deficiency in humans. | 1989 | Am. J. Clin. Nutr. | pmid:2494878 |
| Kaduce TL et al. | Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. | 1989 | J. Biol. Chem. | pmid:2496121 |
| Matsuzaki A et al. | Mechanism of selective killing by dilinoleoylglycerol of cells transformed by the E1A gene of adenovirus type 12. | 1989 | Cancer Res. | pmid:2529026 |
| Hicks M et al. | Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation. | 1989 | Arch. Biochem. Biophys. | pmid:2492180 |
| Furth EE et al. | The effect of endogenous essential and nonessential fatty acids on the uptake and subsequent agonist-induced release of arachidonate. | 1989 | J. Biol. Chem. | pmid:2553711 |
| D'Aquino M et al. | Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2568114 |
| Stammers JP et al. | High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets. | 1989 | Br. J. Nutr. | pmid:2493804 |
| Hrboticky N et al. | Effect of linoleic acid-rich infant formula feeding on brain synaptosomal lipid accretion and enzyme thermotropic behavior in the piglet. | 1989 | J. Lipid Res. | pmid:2769072 |
| Braughler JM and Pregenzer JF | The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. | 1989 | Free Radic. Biol. Med. | pmid:2806938 |
| Hrelia S et al. | Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2570573 |
| Bolton-Smith C et al. | The effect of dietary linoleic acid on rat platelet sialic acid. | 1989 | Biochim. Biophys. Acta | pmid:2775771 |
| Blanken R et al. | Effect of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss of sodium-lauryl-sulphate-induced irritant skin reactions. | 1989 | Contact Derm. | pmid:2706971 |
| Zevenbergen JL and Houtsmuller UM | Effect of dietary fats on linoleic acid metabolism. A radiolabel study in rats. | 1989 | Biochim. Biophys. Acta | pmid:2713382 |
| Levay-Young BK and Nandi S | Spermidine is necessary for, but not the only mediator of, linoleic acid-stimulated alpha-casein accumulation in mouse mammary epithelial cells. | 1989 | Endocrinology | pmid:2759031 |
| Berlin E et al. | Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women. | 1989 | Metab. Clin. Exp. | pmid:2761416 |
| Reddy SR et al. | Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. | 1989 | Am. J. Physiol. | pmid:2764141 |
| Stein O et al. | Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. | 1989 | Biochim. Biophys. Acta | pmid:2730885 |
| Reinaud O et al. | Oxidative metabolism of linoleic acid by human leukocytes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2735926 |
| Cunnane SC et al. | Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. | 1989 | Am. J. Clin. Nutr. | pmid:2801584 |
| Rose DP and Connolly JM | Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803300 |
| Furr HC et al. | The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. | 1989 | J. Nutr. | pmid:2703916 |
| Chen Q et al. | Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. | 1989 | Biochim. Biophys. Acta | pmid:2503032 |
| Chapkin RS et al. | Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. | 1989 | Cancer Res. | pmid:2503244 |
| Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
| Mohsenin V and Gee JL | Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. | 1989 | J. Appl. Physiol. | pmid:2787317 |
| Schneider YJ | Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium. | 1989 | J. Immunol. Methods | pmid:2644356 |
| Watkins BA | Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. | 1989 | Br. J. Nutr. | pmid:2923859 |
| Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
| Girón MD et al. | Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. | 1990 | Biochim. Biophys. Acta | pmid:2369586 |
| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
| Teter BB et al. | Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. | 1990 | J. Nutr. | pmid:2380791 |
| Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
| Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Appel MJ et al. | Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow. | 1990 | Cancer Lett. | pmid:2257542 |
| Pal S and Davis PJ | N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2260969 |
| Shimizu T et al. | Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:2324889 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Hennig B et al. | Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. | 1990 | J. Nutr. | pmid:2329387 |
| Roe CR et al. | 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. | 1990 | J. Clin. Invest. | pmid:2332510 |
| Miyashita K et al. | Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. | 1990 | Biochim. Biophys. Acta | pmid:2386795 |
| Schlame M and Rüstow B | Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. | 1990 | Biochem. J. | pmid:2268287 |
| Ohtani H et al. | Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. | 1990 | J. Lipid Res. | pmid:2280182 |
| Lefkowith J et al. | Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. | 1990 | J. Exp. Med. | pmid:2307932 |
| Buckman DK et al. | Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. | 1990 | J. Nutr. | pmid:2313378 |
| Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
| Buset M et al. | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. | 1990 | Cancer Lett. | pmid:2322935 |
| Katzenellenbogen BS and Norman MJ | Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. | 1990 | Endocrinology | pmid:2404751 |
| Medini L et al. | Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. | 1990 | Biochem. Pharmacol. | pmid:2105092 |
| Kinsella JE and Lokesh B | Dietary lipids, eicosanoids, and the immune system. | 1990 | Crit. Care Med. | pmid:2105185 |
| Kawada H et al. | Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2363935 |
| Lernhardt W | Fatty acid requirement of B lymphocytes activated in vitro. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302243 |
| Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
| Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
| Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
| Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
| Lipids and multiple sclerosis. | 1990 | Lancet | pmid:1973215 | |
| Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
| Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
| Opara EC et al. | Enhancement of endocrine pancreatic secretions by essential fatty acids. | 1990 | J. Surg. Res. | pmid:2187112 |
| Oliver MF | Linoleic acid, antioxidants and coronary heart disease. | 1990 | Biochem. Soc. Trans. | pmid:2088801 |
| Singer P et al. | A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. | 1990 | Atherosclerosis | pmid:2146966 |
| Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| Ando H et al. | Protein kinase C and linoleic acid-induced inhibition of melanogenesis. | 1990 | Pigment Cell Res. | pmid:2077533 |
| Kulkarni AP et al. | Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2105721 |
| Umeda F et al. | Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. | 1990 | Diabetes Res. Clin. Pract. | pmid:2106424 |
| Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
| Green P et al. | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. | 1990 | Am. J. Clin. Nutr. | pmid:2239789 |
| Moore SA et al. | Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. | 1990 | J. Neurochem. | pmid:2115069 |
| Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
| Mensink RP et al. | Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. | 1990 | Eur. J. Clin. Invest. | pmid:2121507 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Kawashima Y et al. | Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. | 1990 | J. Biol. Chem. | pmid:2160962 |
| Bedotti R et al. | Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. | 1990 | Biochim. Biophys. Acta | pmid:2163687 |
| Akamatsu H et al. | Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. | 1990 | J. Invest. Dermatol. | pmid:2143521 |
| Piché LA and Mahadevappa VG | Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. | 1990 | J. Nutr. | pmid:2111377 |
| Weaver BJ et al. | Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. | 1990 | Am. J. Clin. Nutr. | pmid:2181858 |
| Mullarkey CJ et al. | Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2176495 |
| Glasgow WC and Eling TE | Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. | 1990 | Mol. Pharmacol. | pmid:2233691 |
| Hernández-Caselles T et al. | Stability of liposomes on long term storage. | 1990 | J. Pharm. Pharmacol. | pmid:1979618 |
| Abraham RD et al. | Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. | 1990 | Atherosclerosis | pmid:2112389 |
| Vaughan PF and Ball SG | The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. | 1990 | Biochem. Pharmacol. | pmid:1968340 |
| Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
| Kim D and Duff RA | Regulation of K+ channels in cardiac myocytes by free fatty acids. | 1990 | Circ. Res. | pmid:2119911 |
| Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |