Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rosenthal MD and Whitehurst MC | Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. | 1983 | Biochim. Biophys. Acta | pmid:6615875 |
| Rosenthal MD and Whitehurst MC | Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. | 1983 | Biochim. Biophys. Acta | pmid:6297606 |
| Oliw EH | Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301473 |
| Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
| Yoshida M et al. | Linoleate and fatty acid compositions in the serum lipids of Japanese patients with multiple sclerosis. | 1983 | Acta Neurol. Scand. | pmid:6364685 |
| Rustin P et al. | Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. | 1983 | Arch. Biochem. Biophys. | pmid:6414377 |
| Nicholson T and Omer SA | The application of cumulative sum analysis to the investigation of reticulum motility in ruminant animals. | 1983 | Zentralbl Veterinarmed A | pmid:6318476 |
| Kirstein D et al. | Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. | 1983 | Br. J. Nutr. | pmid:6315055 |
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| Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
| Goldmacher VS | Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. | 1983 | Biochem. Pharmacol. | pmid:6189496 |
| Gerzer R et al. | Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6134818 |
| Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
| Lloyd D et al. | Adaptive changes in yeast membranes: catabolite repression and oxygen. | 1983 | Biochem. Soc. Trans. | pmid:6617968 |
| Rapp JH et al. | Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression. | 1983 | J. Lipid Res. | pmid:6644183 |
| MacDonald ML et al. | Role of linoleate as an essential fatty acid for the cat independent of arachidonate synthesis. | 1983 | J. Nutr. | pmid:6408230 |
| Gavigan SJ and Knight BL | The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. | 1983 | Biochem. J. | pmid:6651782 |
| Greenway DL and Dyke KG | The effect of membrane-bound beta-lactamase on linoleic acid sensitivity in Staphylococcus aureus. | 1983 | J. Gen. Microbiol. | pmid:6605415 |
| Breton M et al. | Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6230079 |
| Shultz TD and Leklem JE | Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. | 1983 | Am. J. Clin. Nutr. | pmid:6849273 |
| Ookhtens M and Baker N | Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. | 1983 | Am. J. Physiol. | pmid:6295191 |
| Hoffmann P et al. | Impaired catecholamine inactivation. A prohypertensive stimulus after dietary linoleate deficiency in salt-loaded rats? | 1983 Nov-Dec | Hypertension | pmid:6581124 |
| Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
| Codde JP et al. | Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. | 1984 | J. Hypertens. | pmid:6099384 |
| Chen TC et al. | Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids. | 1984 | J. Lipid Res. | pmid:6099395 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Laakso S | Inhibition of lipid peroxidation by casein. Evidence of molecular encapsulation of 1,4-pentadiene fatty acids. | 1984 | Biochim. Biophys. Acta | pmid:6419780 |
| Benaim G et al. | Different conformational states of the purified Ca2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis. | 1984 | J. Biol. Chem. | pmid:6234313 |
| Grossman S et al. | Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. | 1984 | Biochim. Biophys. Acta | pmid:6424722 |
| Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
| Baba A et al. | Modulation by unsaturated fatty acids of norepinephrine- and adenosine-induced formation of cyclic AMP in brain slices. | 1984 | J. Neurochem. | pmid:6315886 |
| Kitagawa S et al. | Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6324876 |
| Manku MS et al. | Essential fatty acids in the plasma phospholipids of patients with atopic eczema. | 1984 | Br. J. Dermatol. | pmid:6329254 |
| Inouye S | Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid. | 1984 | FEBS Lett. | pmid:6430718 |
| Ramesha CS and Thompson GA | The mechanism of membrane response to chilling. Effect of temperature on phospholipid deacylation and reacylation reactions in the cell surface membrane. | 1984 | J. Biol. Chem. | pmid:6430890 |
| Kitagawa S et al. | Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. | 1984 | Biochim. Biophys. Acta | pmid:6435686 |
| Reeves VB et al. | Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. | 1984 | Am. J. Clin. Nutr. | pmid:6507356 |
| Badwey JA et al. | Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. | 1984 | J. Biol. Chem. | pmid:6330088 |
| Sánchez J and Stumpf PK | The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. | 1984 | Arch. Biochem. Biophys. | pmid:6696430 |
| Chu CH et al. | The activity of 3-hydroxyacyl-CoA epimerase is insufficient to account for the rate of linoleate oxidation in rat heart mitochondria. Evidence for a modified pathway of linoleate degradation. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696754 |
| Cherayil GD | Sialic acid and fatty acid concentrations in lymphocytes, red blood cells and plasma from patients with multiple sclerosis. | 1984 | J. Neurol. Sci. | pmid:6699649 |
| Alao SJ and Balnave D | Growth and carcass composition of broilers fed sunflower oil and olive oil. | 1984 | Br. Poult. Sci. | pmid:6733552 |
| Cunnane SC et al. | Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat. | 1984 | Br. J. Nutr. | pmid:6422980 |
| Curnutte JT et al. | Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. | 1984 | J. Biol. Chem. | pmid:6090448 |
| Chapkin RS and Ziboh VA | Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6439197 |
| Koo SI and Ramlet JS | Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high density lipoprotein cholesterol. | 1984 | Atherosclerosis | pmid:6712766 |
| Harada H et al. | Enhanced suppression of myocardial slow action potentials during hypoxia by free fatty acids. | 1984 | J. Mol. Cell. Cardiol. | pmid:6716492 |
| McMurchie EJ et al. | Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. | 1984 | Am. J. Clin. Nutr. | pmid:6720626 |
| Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
| Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |