Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Oh JM et al. Effects of palmitic acid on TNF-α-induced cytotoxicity in SK-Hep-1 cells. 2012 Toxicol In Vitro pmid:22683933
Harvey KA et al. Trans fatty acids: induction of a pro-inflammatory phenotype in endothelial cells. 2012 Lipids pmid:22684911
Montaño M et al. New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors. 2012 Toxicol. Sci. pmid:22859314
Gutla PV et al. Modulation of plant TPC channels by polyunsaturated fatty acids. 2012 J. Exp. Bot. pmid:23105130
Ebba S et al. The examination of fatty acid taste with edible strips. 2012 Physiol. Behav. pmid:22521910
Ruparel S et al. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. 2012 Pain pmid:22633978
Shimomura K et al. Identification of the plant origin of propolis from Jeju Island, Korea, by observation of honeybee behavior and phytochemical analysis. 2012 Biosci. Biotechnol. Biochem. pmid:23132582
Dramane G et al. STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. 2012 J. Clin. Invest. pmid:22546859
Naqvi AZ et al. Dietary fatty acids and peripheral artery disease in adults. 2012 Atherosclerosis pmid:22552117
Joshi S et al. Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. 2012 Org. Biomol. Chem. pmid:22986997
Perdriau S et al. Selective conversion of polyenes to monoenes by RuCl(3) -catalyzed transfer hydrogenation: the case of cashew nutshell liquid. 2012 ChemSusChem pmid:23060315
O'Donnell-Megaro AM et al. Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. 2012 J. Dairy Sci. pmid:23063161
Krugner-Higby L et al. Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. 2012 Comp. Med. pmid:23043777
Coimbra MC and Jorge N Fatty acids and bioactive compounds of the pulps and kernels of Brazilian palm species, guariroba (Syagrus oleraces), jerivá (Syagrus romanzoffiana) and macaúba (Acrocomia aculeata). 2012 J. Sci. Food Agric. pmid:21922463
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
Shah BP et al. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. 2012 Am. J. Physiol., Cell Physiol. pmid:21998136
Marincola FC et al. A metabolomic study of preterm human and formula milk by high resolution NMR and GC/MS analysis: preliminary results. 2012 J. Matern. Fetal. Neonatal. Med. pmid:23025771
Kanter JE et al. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. 2012 Biochim. Biophys. Acta pmid:22020260
Poompachee K and Chudapongse N Comparison of the antioxidant and cytotoxic activities of Phyllanthus virgatus and Phyllanthus amarus extracts. 2012 Med Princ Pract pmid:22024634
Sandoval-Montemayor NE et al. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. 2012 Molecules pmid:22992784
Huang FC and Schwab W Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. 2012 Plant Biotechnol. J. pmid:22967031
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Florence AC et al. Fatty acid profile, trans-octadecenoic, α-linolenic and conjugated linoleic acid contents differing in certified organic and conventional probiotic fermented milks. 2012 Food Chem pmid:22980792
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Regensburger J et al. Fatty acids and vitamins generate singlet oxygen under UVB irradiation. 2012 Exp. Dermatol. pmid:22229443
Stachowska E et al. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. 2012 Int J Food Sci Nutr pmid:21721848
Gursoy O et al. The effect of using different probiotic cultures on conjugated linoleic acid (CLA) concentration and fatty acid composition of white pickle cheese. 2012 Int J Food Sci Nutr pmid:22166042
Padilla MN et al. Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. 2012 Phytochemistry pmid:22169502
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Taârit MB et al. Physiological changes, phenolic content and antioxidant activity of Salvia officinalis L. grown under saline conditions. 2012 J. Sci. Food Agric. pmid:22173568
Byun HJ et al. Lipid ingredients in moisturizers can modulate skin responses to UV in barrier-disrupted human skin in vivo. 2012 J. Dermatol. Sci. pmid:22209282
Cheguru P et al. Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. 2012 Pflugers Arch. pmid:22218833
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Beevi SS et al. Polyphenolics profile and antioxidant properties of Raphanus sativus L. 2012 Nat. Prod. Res. pmid:21714734
Zengin G et al. Composition of essential oil and antioxidant capacity of Centaurea drabifolia Sm. subsp. detonsa (Bornm.) Wagenitz, endemic to Turkey. 2012 Nat. Prod. Res. pmid:21714737
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Zein CO et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. 2012 Hepatology pmid:22505276
Fatima T et al. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. 2012 PLoS ONE pmid:22558083
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225
Marei WF et al. Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. 2012 Reprod. Fertil. Dev. pmid:22697118
Jarvis MF Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. 2012 Pain pmid:22681878
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Wu J et al. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. 2012 Acta Biochim. Biophys. Sin. (Shanghai) pmid:22687573
Reynolds CM et al. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. 2012 Mol Nutr Food Res pmid:22700321
Ladeira MM et al. Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. 2012 Recent Pat Food Nutr Agric pmid:22702746
Monteiro J et al. Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse. 2012 Lipids Health Dis pmid:22642787
Yu T et al. Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. 2012 Pflugers Arch. pmid:22644615
Xie J et al. Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. 2012 Nat. Prod. Res. pmid:21707231
Mujtaba SF et al. Production of ROS by photosensitized anthracene under sunlight and UV-R at ambient environmental intensities. 2011 Sep-Oct Photochem. Photobiol. pmid:21668866