Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Bruder ED et al. An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12689852
Sclafani A et al. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17804586
Al-Khalifa A et al. Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17122327
Dailey MJ et al. Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24452547
Whigham LD et al. Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11893615
Zhou Y et al. UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. 2017 Am. J. Physiol. Renal Physiol. pmid:28424210
Collett ED et al. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. 2001 Am. J. Physiol., Cell Physiol. pmid:11287318
Houston M et al. Oxidized linoleic acid regulates expression and shedding of syndecan-4. 2005 Am. J. Physiol., Cell Physiol. pmid:15469957
Suh HN et al. Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. 2008 Am. J. Physiol., Cell Physiol. pmid:18842827
Shah BP et al. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. 2012 Am. J. Physiol., Cell Physiol. pmid:21998136
González-Abuín N et al. Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. 2014 Am. J. Physiol., Cell Physiol. pmid:24371039
McKay MC and Worley JF Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. 2001 Am. J. Physiol., Cell Physiol. pmid:11546665
Reiner WB et al. Fatty acids in mountain gorilla diets: implications for primate nutrition and health. 2014 Am. J. Primatol. pmid:24243235
Kawada H et al. Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2363935
Hill EM et al. Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9569236
Cavicchioli P et al. Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids. 2001 Am. J. Respir. Crit. Care Med. pmid:11208626
Graczyk TK and Shiff CJ Recovery of avian schistosome cercariae from water using penetration stimulant matrix with an unsaturated fatty acid. 2000 Sep-Oct Am. J. Trop. Med. Hyg. pmid:11388510
Mpagi JL et al. Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides. 2000 Am. J. Trop. Med. Hyg. pmid:11304059
Kim CH et al. Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. 2008 Anaerobe pmid:17996466
Shen Q et al. Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. 2010 Anaerobe pmid:20601030
Wang YL et al. LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. 2005 Anal Bioanal Chem pmid:16132135
Ito J et al. A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. 2016 Anal Bioanal Chem pmid:27549797
Tao X et al. GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. 2008 Anal Bioanal Chem pmid:18622754
Billault I et al. Probing substrate-product relationships by natural abundance deuterium 2D NMR spectroscopy in liquid-crystalline solvents: epoxidation of linoleate to vernoleate by two different plant enzymes. 2012 Anal Bioanal Chem pmid:22349323
Wejnerowska G et al. Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. 2008 Anal Sci pmid:18544865
Degousée N et al. Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. 1995 Anal. Biochem. pmid:7733454
KOKATNUR MG et al. A RAPID METHOD FOR THE PREPARATION OF PEROXIDES FROM AUTOXIDIZED METHYL ESTERS OF FATTY ACIDS. 1965 Anal. Biochem. pmid:14340025
López-Nicolás JM et al. An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. 1994 Anal. Biochem. pmid:7810887
Gibian MJ and Vandenberg P Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. 1987 Anal. Biochem. pmid:3116881
Kotani A et al. Determination of plasma free fatty acids by high-performance liquid chromatography with electrochemical detection. 2000 Anal. Biochem. pmid:10933857
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
KOEHLER WR et al. A METHOD FOR SEPARATING SATURATED FATTY ACID ESTERS FROM UNSATURATED ESTERS FOR GAS CHROMATOGRAPHIC ANALYSIS. 1964 Anal. Biochem. pmid:14213999
Pourplanche C et al. Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. 1991 Anal. Biochem. pmid:1789419
Andre JC and Funk MO Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. 1986 Anal. Biochem. pmid:3101541
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Cho H et al. Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. 2003 Anal. Biochem. pmid:12782030
Auerbach BJ et al. A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. 1992 Anal. Biochem. pmid:1632527
PINTER KG et al. QUANTITATIVE DETERMINATION OF SERUM TRIGLYCERIDES BY GLASS-FIBER PAPER CHROMATOGRAPHY. 1964 Anal. Biochem. pmid:14186669
Waddington E et al. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. 2001 Anal. Biochem. pmid:11355856
Wu D et al. Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. 2009 Anal. Chim. Acta pmid:19185115
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Zeng YX et al. Comparative analysis of volatile components from Clematis species growing in China. 2007 Anal. Chim. Acta pmid:17606017
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Kreich M and Claus P Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. 2005 Angew. Chem. Int. Ed. Engl. pmid:16315163
O'Quinn PR et al. Conjugated linoleic acid. 2000 Anim Health Res Rev pmid:11706843
McNamara S et al. Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. 2003 Anim. Reprod. Sci. pmid:12853178
Kawahara S et al. Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. 2009 Anim. Sci. J. pmid:20163609
Shibata H et al. Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. 2011 Anim. Sci. J. pmid:21794014
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225