Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Grammatopoulos D et al. The human myometrial CRH receptor: G proteins and second messengers. 1994 Mol. Cell. Endocrinol. pmid:8206332
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Carpenter KL et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. 1994 Biochem. J. pmid:7999000
Jones RE A hypothesis for early intervention in SIDS. 1994 Clin Pediatr (Phila) pmid:7813148
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Lafond J et al. Linoleic acid transport by human placental syncytiotrophoblast membranes. 1994 Eur. J. Biochem. pmid:8001588
Simopoulos AP Is insulin resistance influenced by dietary linoleic acid and trans fatty acids? 1994 Free Radic. Biol. Med. pmid:8001841
Eder K and Kirchgessner M Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. 1994 J. Nutr. pmid:7931700
Yam D et al. Insulin and glucose status, tissue and plasma lipids in patients with tumours of the ovary or endometrium: possible dietary implications. 1994 Br. J. Cancer pmid:7981074
Hernández-Muñoz I et al. Toxic oil stimulates collagen synthesis acting at a pretranslational level in cultured fat-storing cells. 1994 Gastroenterology pmid:8119541
Loidl-Stahlhofen A and Spiteller G alpha-Hydroxyaldehydes, products of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8117742
Fuhrman B et al. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. 1994 Atherosclerosis pmid:7840815
Andrassy RJ et al. Linoleic acid enhances mitogen response and survival of septic weanling rats. 1994 J. Pediatr. Surg. pmid:8201499
Hoving EB et al. Gestational age dependency of essential fatty acids in cord plasma cholesterol esters and triglycerides. 1994 Pediatr. Res. pmid:8047383
Nowak D et al. Antioxidant properties of Ambroxol. 1994 Free Radic. Biol. Med. pmid:8005537
Paiement J et al. Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. 1994 Biochim. Biophys. Acta pmid:8142417
Pronczuk A et al. Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils. 1994 FASEB J. pmid:7958627
Pawlosky R et al. Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. 1994 J. Lipid Res. pmid:7868981
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Sacks GS et al. Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. 1994 May-Jun JPEN J Parenter Enteral Nutr pmid:7914941
Kim C et al. A comprehensive evaluation of the vial equilibration method for quantification of the metabolism of volatile organic chemicals. Trichloroethylene. 1994 Nov-Dec Drug Metab. Dispos. pmid:7895602
Bailey JM et al. Dietary linoleic acid in alcohol-induced liver cirrhosis. 1995 Biochem. Soc. Trans. pmid:7672270
López-Nicolás JM et al. Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. 1995 Biochem. J. pmid:7755559
Degousée N et al. Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. 1995 Anal. Biochem. pmid:7733454
Chen CC and Chen CS Brugia pahangi: effects of melanization on the uptake of nutrients by microfilariae in vitro. 1995 Exp. Parasitol. pmid:7628569
Umezawa M et al. Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). 1995 Brain Res. pmid:7712178
van Greevenbroek MM et al. Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. 1995 J. Lipid Res. pmid:7706938
Bayon Y et al. Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. 1995 J. Lipid Res. pmid:7706947
Welsch CW Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. 1995 Free Radic. Biol. Med. pmid:7750800
Demmelmair H et al. Estimation of arachidonic acid synthesis in full term neonates using natural variation of 13C content. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:8576811
Ritenbaugh C et al. Risk factors for Barrett's oesophagus: a life history approach to behavioural assessment in the distant past. 1995 Eur. J. Cancer Prev. pmid:8580781
Siguel EN and Ratnayake WM Trans-fatty acid patterns in patients with demonstrated coronary artery disease. 1995 Am. J. Cardiol. pmid:7856548
Croft KD et al. Oxidation of low-density lipoproteins: effect of antioxidant content, fatty acid composition and intrinsic phospholipase activity on susceptibility to metal ion-induced oxidation. 1995 Biochim. Biophys. Acta pmid:7857965
Sarel I and Widmaier EP Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. 1995 Am. J. Physiol. pmid:7611525
Boscá F et al. Evaluation of ketoprofen (R,S and R/S) phototoxicity by a battery of in vitro assays. 1995 J. Photochem. Photobiol. B, Biol. pmid:8583281
Nada MA et al. Evidence for intermediate channeling in mitochondrial beta-oxidation. 1995 J. Biol. Chem. pmid:7822275
Antras-Ferry J et al. Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes. 1995 Eur. J. Biochem. pmid:8536680
Mirzoeva OK et al. Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids. 1995 FEBS Lett. pmid:8549743
Périchon R and Bourre JM Peroxisomal beta-oxidation activity and catalase activity during development and aging in mouse liver. 1995 Biochimie pmid:8589059
Rose DP et al. Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. 1995 Nutr Cancer pmid:7491296
Roberts TL et al. trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. 1995 Lancet pmid:7837861
Mantzioris E et al. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. 1995 Am. J. Clin. Nutr. pmid:7840069
Siguel E Does linoleic acid contribute to coronary artery disease? 1995 Am. J. Clin. Nutr. pmid:7840081
Ip C et al. Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. 1995 Nutr Cancer pmid:8610043
Fushiki T et al. Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides. 1995 J. Nutr. pmid:7876928
Yu WK and Wells PG Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. 1995 Toxicol. Appl. Pharmacol. pmid:7878664
Cho Y and Ziboh VA Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. 1995 J. Nutr. pmid:7472653
Murai A et al. Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. 1995 Br. Poult. Sci. pmid:8746984
Christen MO et al. Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. 1995 Meth. Enzymol. pmid:7476369
Fellner V et al. Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. 1995 J. Dairy Sci. pmid:8786265
Johanning GL and Lin TY Unsaturated fatty acid effects on human breast cancer cell adhesion. 1995 Nutr Cancer pmid:7491298
Groscolas R et al. Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. 1995 Nutr Cancer pmid:7491300
Teboul L et al. Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. 1995 J. Biol. Chem. pmid:7499310
Jones RE A common factor for cardiac or respiratory failure in SIDS. 1995 Clin Pediatr (Phila) pmid:7774147
Kerner J et al. Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. 1995 Am. J. Physiol. pmid:7485605
Iwase H et al. pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. 1995 Biochem. Biophys. Res. Commun. pmid:7488065
Abdel Baset H et al. Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni. 1995 Mol. Biochem. Parasitol. pmid:8577345
Norman HA et al. Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. 1995 FEBS Lett. pmid:7615067
Camacho M et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. 1995 J. Biol. Chem. pmid:7615528
Nakayama T et al. Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. 1995 Biochem. Biophys. Res. Commun. pmid:7575511
Emmison N et al. Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. 1995 Am. J. Physiol. pmid:7631907
Rao GN et al. Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. 1995 J. Clin. Invest. pmid:7635978
Laneuville O et al. Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. 1995 J. Biol. Chem. pmid:7642610
Blée E and Schuber F Stereocontrolled hydrolysis of the linoleic acid monoepoxide regioisomers catalyzed by soybean epoxide hydrolase. 1995 Eur. J. Biochem. pmid:7601104
Shintani T et al. Recognition system for dietary fatty acids in the rat small intestine. 1995 Biosci. Biotechnol. Biochem. pmid:7549092
van Tol A et al. Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. 1995 Atherosclerosis pmid:7669083
Rodier M et al. Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in NIDDM with secondary failure to oral antidiabetic agents. 1995 Diabetes Res. Clin. Pract. pmid:7587908
Engman L et al. Organotellurium compounds as efficient retarders of lipid peroxidation in methanol. 1995 Free Radic. Biol. Med. pmid:7590393
Jenkins TC Butylsoyamide protects soybean oil from ruminal biohydrogenation: effects of butylsoyamide on plasma fatty acids and nutrient digestion in sheep. 1995 J. Anim. Sci. pmid:7608016
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Chu S et al. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624373
Rudel LL et al. Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. 1995 Am. J. Clin. Nutr. pmid:7625361
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van der Heijdt LM et al. Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. 1995 Eur. J. Biochem. pmid:7628469
Guo L et al. Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. 1995 Free Radic. Biol. Med. pmid:7628726
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Krugliak M et al. Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. 1995 Exp. Parasitol. pmid:7628573
Heiskanen K et al. Interactions of cis-fatty acids and their anilides with formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and dioctanoyl-s,n-glycerol in human leukocytes. 1995 Toxicology pmid:8560489
Abdel-Fattah G et al. Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. 1995 J. Lipid Res. pmid:7665997
Pietsch A et al. N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. 1995 Cell Biochem. Funct. pmid:7554100
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Bellavite P et al. Correlations between the intensity of fMLP-dependent respiratory burst and cellular fatty acid composition in human neutrophils. 1995 Br. J. Haematol. pmid:7873377
Appel MJ and Woutersen RA Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. 1995 Cancer Lett. pmid:7634246
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Schmitt A et al. Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. 1995 Biochim. Biophys. Acta pmid:7786889
Ghosh D et al. Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. 1995 Structure pmid:7788294
Chen ZY et al. Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. 1995 Am. J. Physiol. pmid:7864247
van de Sandt JJ et al. Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. 1995 Fundam Appl Toxicol pmid:7601324
Lodge JK et al. Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. 1995 Biochim. Biophys. Acta pmid:7766690
Santanam N and Parthasarathy S Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. 1995 J. Clin. Invest. pmid:7769102
Jiang WG et al. Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. 1995 Br. J. Cancer pmid:7710939
Khan MF et al. Hematopoietic toxicity of linoleic acid anilide: importance of aniline. 1995 Fundam Appl Toxicol pmid:7665006
Mize CE et al. Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. 1995 J. Lipid Res. pmid:7665996
Romon M et al. Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. 1995 Metab. Clin. Exp. pmid:7666786
Sakai T et al. A lipid peroxidation-derived aldehyde, 4-hydroxy-2-nonenal and omega 6 fatty acids contents in meats. 1995 Biosci. Biotechnol. Biochem. pmid:7670203
Greco AV et al. Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. 1995 Clin. Chim. Acta pmid:7586583