Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Umezawa M et al. | Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). | 1995 | Brain Res. | pmid:7712178 |
van Greevenbroek MM et al. | Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. | 1995 | J. Lipid Res. | pmid:7706938 |
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Welsch CW | Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. | 1995 | Free Radic. Biol. Med. | pmid:7750800 |
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Ritenbaugh C et al. | Risk factors for Barrett's oesophagus: a life history approach to behavioural assessment in the distant past. | 1995 | Eur. J. Cancer Prev. | pmid:8580781 |
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Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
Boscá F et al. | Evaluation of ketoprofen (R,S and R/S) phototoxicity by a battery of in vitro assays. | 1995 | J. Photochem. Photobiol. B, Biol. | pmid:8583281 |
Nada MA et al. | Evidence for intermediate channeling in mitochondrial beta-oxidation. | 1995 | J. Biol. Chem. | pmid:7822275 |
Antras-Ferry J et al. | Fatty acids and fibrates are potent inducers of transcription of the phosphenolpyruvate carboxykinase gene in adipocytes. | 1995 | Eur. J. Biochem. | pmid:8536680 |
Mirzoeva OK et al. | Competitive inhibition of the 5-lipoxygenase-catalysed linoleate oxidation by arachidonic and 5-hydroperoxy-eicosatetraenoic acids. | 1995 | FEBS Lett. | pmid:8549743 |
Périchon R and Bourre JM | Peroxisomal beta-oxidation activity and catalase activity during development and aging in mouse liver. | 1995 | Biochimie | pmid:8589059 |
Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
Roberts TL et al. | trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. | 1995 | Lancet | pmid:7837861 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
Ip C et al. | Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. | 1995 | Nutr Cancer | pmid:8610043 |
Fushiki T et al. | Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides. | 1995 | J. Nutr. | pmid:7876928 |
Yu WK and Wells PG | Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878664 |
Cho Y and Ziboh VA | Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. | 1995 | J. Nutr. | pmid:7472653 |
Murai A et al. | Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. | 1995 | Br. Poult. Sci. | pmid:8746984 |
Christen MO et al. | Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. | 1995 | Meth. Enzymol. | pmid:7476369 |
Fellner V et al. | Steady-state rates of linoleic acid biohydrogenation by ruminal bacteria in continuous culture. | 1995 | J. Dairy Sci. | pmid:8786265 |
Johanning GL and Lin TY | Unsaturated fatty acid effects on human breast cancer cell adhesion. | 1995 | Nutr Cancer | pmid:7491298 |
Groscolas R et al. | Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. | 1995 | Nutr Cancer | pmid:7491300 |
Teboul L et al. | Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. | 1995 | J. Biol. Chem. | pmid:7499310 |
Jones RE | A common factor for cardiac or respiratory failure in SIDS. | 1995 | Clin Pediatr (Phila) | pmid:7774147 |
Kerner J et al. | Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. | 1995 | Am. J. Physiol. | pmid:7485605 |
Iwase H et al. | pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488065 |
Abdel Baset H et al. | Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni. | 1995 | Mol. Biochem. Parasitol. | pmid:8577345 |
Norman HA et al. | Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. | 1995 | FEBS Lett. | pmid:7615067 |
Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
Nakayama T et al. | Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575511 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Rao GN et al. | Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. | 1995 | J. Clin. Invest. | pmid:7635978 |
Laneuville O et al. | Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. | 1995 | J. Biol. Chem. | pmid:7642610 |
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van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
Rodier M et al. | Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in NIDDM with secondary failure to oral antidiabetic agents. | 1995 | Diabetes Res. Clin. Pract. | pmid:7587908 |
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Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
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Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
van der Heijdt LM et al. | Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. | 1995 | Eur. J. Biochem. | pmid:7628469 |
Guo L et al. | Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. | 1995 | Free Radic. Biol. Med. | pmid:7628726 |
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Heiskanen K et al. | Interactions of cis-fatty acids and their anilides with formyl-methionyl-leucyl-phenylalanine, phorbol myristate acetate and dioctanoyl-s,n-glycerol in human leukocytes. | 1995 | Toxicology | pmid:8560489 |
Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Bellavite P et al. | Correlations between the intensity of fMLP-dependent respiratory burst and cellular fatty acid composition in human neutrophils. | 1995 | Br. J. Haematol. | pmid:7873377 |
Appel MJ and Woutersen RA | Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. | 1995 | Cancer Lett. | pmid:7634246 |
Leis HJ et al. | On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. | 1995 | Br. J. Pharmacol. | pmid:7735686 |
Schmitt A et al. | Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. | 1995 | Biochim. Biophys. Acta | pmid:7786889 |
Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
van de Sandt JJ et al. | Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. | 1995 | Fundam Appl Toxicol | pmid:7601324 |
Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
Santanam N and Parthasarathy S | Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. | 1995 | J. Clin. Invest. | pmid:7769102 |
Jiang WG et al. | Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. | 1995 | Br. J. Cancer | pmid:7710939 |
Khan MF et al. | Hematopoietic toxicity of linoleic acid anilide: importance of aniline. | 1995 | Fundam Appl Toxicol | pmid:7665006 |
Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |
Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
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