Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Lasa A et al. The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. 2011 Sep-Oct Nutr Hosp pmid:22072344
Mujtaba SF et al. Production of ROS by photosensitized anthracene under sunlight and UV-R at ambient environmental intensities. 2011 Sep-Oct Photochem. Photobiol. pmid:21668866
Ramandi NF et al. Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. 2011 Nov-Dec J. Food Sci. pmid:22416687
Olszewska MA Variation in the phenolic content and in vitro antioxidant activity of Sorbus aucuparia leaf extracts during vegetation. 2011 Nov-Dec Acta Pol Pharm pmid:22125960
Olszewska MA In vitro antioxidant activity and total phenolic content of the inflorescences, leaves and fruits of Sorbus torminalis (L.) Crantz. 2011 Nov-Dec Acta Pol Pharm pmid:22125961
Kezutyte T et al. Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo. 2011 Nov-Dec Acta Pol Pharm pmid:22125963
China R et al. In vitro antioxidant activity of different cultivars of banana flower (Musa paradicicus L.) extracts available in India. 2011 Nov-Dec J. Food Sci. pmid:22416691
Qu WX et al. Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. 2011 May-Jun Phytochem Anal pmid:20848395
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
de Luis DA et al. Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. 2011 Jul-Aug Nutr Hosp pmid:22470031
Aluf Y et al. Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. 2011 Jul-Aug Neuropharmacology pmid:21414328
Kruska N and Reiser G Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. 2011 Neurobiol. Dis. pmid:21570468
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Monfregola L et al. Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. 2011 Biomacromolecules pmid:21553919
Márquez-Castillo A and Vidal-Quintanar RL Improvements in the shelf life of commercial corn dry masa flour (CMF) by reducing lipid oxidation. 2011 J. Food Sci. pmid:21535741
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
de Lima-Salgado TM et al. Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. 2011 Cell Biochem. Biophys. pmid:20809180
Andreu I et al. Probing lipid peroxidation by using linoleic acid and benzophenone. 2011 Chemistry pmid:21793062
Shibata H et al. Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. 2011 Anim. Sci. J. pmid:21794014
Royan M et al. Effects of conjugated linoleic acid, fish oil and soybean oil on PPARs (α & γ) mRNA expression in broiler chickens and their relation to body fat deposits. 2011 Int J Mol Sci pmid:22272093
Prasad A and Pospíšil P Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. 2011 PLoS ONE pmid:21799835
Li YC et al. Effects of conjugated linoleic acid on cleavage of amyloid precursor protein via PPARγ. 2011 Neurol. Sci. pmid:21800078
Baâtour O et al. Salt effects on Origanum majorana fatty acid and essential oil composition. 2011 J. Sci. Food Agric. pmid:21800320
Zened A et al. Starch and oil in the donor cow diet and starch in substrate differently affect the in vitro ruminal biohydrogenation of linoleic and linolenic acids. 2011 J. Dairy Sci. pmid:22032386
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Banta JP et al. Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. 2011 J. Anim. Sci. pmid:21788431
Gibson R and Makrides M α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22019216
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Simon E et al. Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression. 2011 Exp. Eye Res. pmid:21821023
Arawwawala M et al. In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. 2011 Acta. Biol. Hung. pmid:21840826
Hanada H et al. Induction of apoptosis and lipogenesis in human preadipocyte cell line by n-3 PUFAs. 2011 Cell Biol. Int. pmid:20812919
Ogawa E et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. 2011 J. Invest. Dermatol. pmid:21068754
Arciniega JC et al. Effects of free fatty acids on meibomian lipid films. 2011 Exp. Eye Res. pmid:21718696
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Gorissen L et al. Linoleate isomerase activity occurs in lactic acid bacteria strains and is affected by pH and temperature. 2011 J. Appl. Microbiol. pmid:21699633
Li M et al. Isolation of a novel C18-Δ9 polyunsaturated fatty acid specific elongase gene from DHA-producing Isochrysis galbana H29 and its use for the reconstitution of the alternative Δ8 pathway in Saccharomyces cerevisiae. 2011 Biotechnol. Lett. pmid:21538137
Pi F et al. Solid-state low temperature→middle temperature phase transition of linoleic acid studied by FTIR spectroscopy. 2011 J Phys Chem B pmid:21520953
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Liou AP et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. 2011 Gastroenterology pmid:20955703
Perona JS et al. Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. 2011 Metab. Clin. Exp. pmid:20934731
Pan Z et al. Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21295151
Tsubura A et al. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. 2011 Anticancer Agents Med Chem pmid:21269259
Chohany LE et al. Cationic substrates of soybean lipoxygenase-1. 2011 Bioorg. Chem. pmid:21257189
Das R et al. Synthesis of linoleic acid capped copper nanoparticles and their fluorescence study. 2011 J Fluoresc pmid:21221748
Senadheera SD et al. Effects of dietary α-linolenic acid (18:3n-3)/linoleic acid (18:2n-6) ratio on fatty acid metabolism in Murray cod (Maccullochella peelii peelii). 2011 J. Agric. Food Chem. pmid:21222433
Liu WM et al. Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes. 2011 Mol. Cell. Biochem. pmid:21274596
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381