Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Monastero R et al. | Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids. | 2017 | Eur J Nutr | pmid:26707994 |
Fan Y et al. | Study of the pH-sensitive mechanism of tumor-targeting liposomes. | 2017 | Colloids Surf B Biointerfaces | pmid:27940165 |
Woodfield HK et al. | Spatial and Temporal Mapping of Key Lipid Species in Brassica napus Seeds. | 2017 | Plant Physiol. | pmid:28188274 |
Teh SS et al. | Recovery and Utilization of Palm Oil Mill Effluent Source as Value-Added Food Products. | 2017 | J Oleo Sci | pmid:29093377 |
De Weirdt R et al. | Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress associated with high concentrations of poly-unsaturated fat. | 2017 | Environ. Microbiol. | pmid:27883264 |
Buckley MT et al. | Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes. | 2017 | Mol. Biol. Evol. | pmid:28333262 |
Inzaugarat ME et al. | New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans. | 2017 | PLoS ONE | pmid:28257515 |
Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
Fujii M | Pathogenesis of Diet-induced Atopic Dermatitis in Hairless Mice. | 2017 | Yakugaku Zasshi | pmid:28049895 |
Turell L et al. | The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid. | 2017 | J. Biol. Chem. | pmid:27923813 |
Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
Hellström F et al. | Association between plasma concentrations of linoleic acid-derived oxylipins and the perceived pain scores in an exploratory study in women with chronic neck pain. | 2016 | BMC Musculoskelet Disord | pmid:26916287 |
Ripoll-Rozada J et al. | Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. | 2016 | Mol. Microbiol. | pmid:26915347 |
Harris WS et al. | Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study. | 2016 | PLoS ONE | pmid:26881936 |
Puebla C et al. | Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. | 2016 | Biochim. Biophys. Acta | pmid:26869446 |
Rashed MM et al. | Effect of ultrasonic treatment on total phenolic extraction from Lavandula pubescens and its application in palm olein oil industry. | 2016 | Ultrason Sonochem | pmid:26584982 |
Ishida K and Jolly ER | Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion. | 2016 | PLoS Negl Trop Dis | pmid:27611863 |
Venäläinen TM et al. | Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. | 2016 | Am. J. Clin. Nutr. | pmid:27581473 |
Sakayori N et al. | Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice. | 2016 | Tohoku J. Exp. Med. | pmid:27558477 |