Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
| Teter BB et al. | Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. | 1990 | J. Nutr. | pmid:2380791 |
| DeLange RJ and Glazer AN | Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. | 1990 | Arch. Biochem. Biophys. | pmid:2297222 |
| Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
| Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Shimizu T et al. | Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:2324889 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Hennig B et al. | Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. | 1990 | J. Nutr. | pmid:2329387 |
| Roe CR et al. | 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. | 1990 | J. Clin. Invest. | pmid:2332510 |
| Miyashita K et al. | Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. | 1990 | Biochim. Biophys. Acta | pmid:2386795 |
| Ohtani H et al. | Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. | 1990 | J. Lipid Res. | pmid:2280182 |
| Lefkowith J et al. | Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. | 1990 | J. Exp. Med. | pmid:2307932 |
| Buckman DK et al. | Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. | 1990 | J. Nutr. | pmid:2313378 |
| Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
| Buset M et al. | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. | 1990 | Cancer Lett. | pmid:2322935 |
| Katzenellenbogen BS and Norman MJ | Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. | 1990 | Endocrinology | pmid:2404751 |
| Jensen MD et al. | Measurement of non-steady-state free fatty acid turnover. | 1990 | Am. J. Physiol. | pmid:2405695 |
| Kinsella JE and Lokesh B | Dietary lipids, eicosanoids, and the immune system. | 1990 | Crit. Care Med. | pmid:2105185 |
| Lernhardt W | Fatty acid requirement of B lymphocytes activated in vitro. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302243 |
| Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
| Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
| Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
| Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
| Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
| Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
| Opara EC et al. | Enhancement of endocrine pancreatic secretions by essential fatty acids. | 1990 | J. Surg. Res. | pmid:2187112 |
| Oliver MF | Linoleic acid, antioxidants and coronary heart disease. | 1990 | Biochem. Soc. Trans. | pmid:2088801 |
| Singer P et al. | A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. | 1990 | Atherosclerosis | pmid:2146966 |
| Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
| Ando H et al. | Protein kinase C and linoleic acid-induced inhibition of melanogenesis. | 1990 | Pigment Cell Res. | pmid:2077533 |
| Kulkarni AP et al. | Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2105721 |
| Umeda F et al. | Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. | 1990 | Diabetes Res. Clin. Pract. | pmid:2106424 |
| Green P et al. | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. | 1990 | Am. J. Clin. Nutr. | pmid:2239789 |
| Mimouni V and Poisson JP | Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities. | 1990 | Horm. Metab. Res. | pmid:2227799 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Kawashima Y et al. | Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. | 1990 | J. Biol. Chem. | pmid:2160962 |
| Piché LA and Mahadevappa VG | Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. | 1990 | J. Nutr. | pmid:2111377 |
| Weaver BJ et al. | Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. | 1990 | Am. J. Clin. Nutr. | pmid:2181858 |
| Masini E et al. | Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. | 1990 | Biochem. Pharmacol. | pmid:1690007 |
| Stocker R et al. | Antioxidant activities of bile pigments: biliverdin and bilirubin. | 1990 | Meth. Enzymol. | pmid:2233302 |
| Glasgow WC and Eling TE | Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. | 1990 | Mol. Pharmacol. | pmid:2233691 |
| Abraham RD et al. | Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. | 1990 | Atherosclerosis | pmid:2112389 |
| Vaughan PF and Ball SG | The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. | 1990 | Biochem. Pharmacol. | pmid:1968340 |
| Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |