Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Seizures D012640 87 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Poirier H et al. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. 2001 Biochem. J. pmid:11284737
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. 1963 Biochem. J. pmid:14071526
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. 1963 Biochem. J. pmid:14071527
López-Nicolás JM et al. Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. 1995 Biochem. J. pmid:7755559
LEAT WM FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. 1963 Biochem. J. pmid:14097364
Enser M and Roberts JL The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. 1982 Biochem. J. pmid:6128973
Jones AL et al. Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. 1993 Biochem. J. pmid:8250841
Carpenter KL et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. 1994 Biochem. J. pmid:7999000
Clouet P et al. Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. 1989 Biochem. J. pmid:2597132
Williams JP et al. The role of phosphatidylcholine in fatty acid exchange and desaturation in Brassica napus L. leaves. 2000 Biochem. J. pmid:10861220
Stymne S and Stobart AK Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). 1986 Biochem. J. pmid:3028375
Lang I et al. A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. 2008 Biochem. J. pmid:18031288
Reid JC and Husbands DR Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. 1985 Biochem. J. pmid:3977825
Swida A et al. Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. 2008 Biochem. J. pmid:18402555
Babizhayev MA et al. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. 1994 Biochem. J. pmid:7998987
JAMES AT et al. THE BIOSYNTHESIS OF RICINOLEIC ACID. 1965 Biochem. J. pmid:14340094
Thuillier P et al. Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. 2002 Biochem. J. pmid:12069687
Calder PC et al. Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. 1994 Biochem. J. pmid:8141773
Schaloske R et al. Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. 1998 Biochem. J. pmid:9601085
Hughes RK et al. Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. 1998 Biochem. J. pmid:9639559
Finn RD et al. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. 2009 Biochem. J. pmid:18778245
Kang JX et al. The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. 1992 Biochem. J. pmid:1323271
Koshiishi I et al. Radical scavenger can scavenge lipid allyl radicals complexed with lipoxygenase at lower oxygen content. 2006 Biochem. J. pmid:16396633
Arslan P et al. cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. 1984 Biochem. J. pmid:6696740
Rayner BS et al. Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution. 2004 Biochem. J. pmid:15035657
Stymne S and Stobart AK The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). 1984 Biochem. J. pmid:6743281
Gavigan SJ and Knight BL The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. 1983 Biochem. J. pmid:6651782
O'donnell VB and Kühn H Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. 1997 Biochem. J. pmid:9355754
Haines KA et al. The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. 1987 Biochem. J. pmid:3032161
Griffiths G et al. Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). 1988 Biochem. J. pmid:3421914
Louet JF et al. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. 2001 Biochem. J. pmid:11171094
Ando H et al. Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. 2006 Biochem. J. pmid:16232122
Brodhun F et al. PpoC from Aspergillus nidulans is a fusion protein with only one active haem. 2010 Biochem. J. pmid:19878096
Grechkin AN et al. The lipoxygenase pathway in tulip (Tulipa gesneriana): detection of the ketol route. 2000 Biochem. J. pmid:11085944
Huang YS et al. Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. 1994 Biochem. Med. Metab. Biol. pmid:7910749
Poisson JP et al. Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. 1993 Biochem. Med. Metab. Biol. pmid:8382502
Jump DB et al. Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. 2011 Biochem. Pharmacol. pmid:21184748
Bomalaski JS et al. Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. 1987 Biochem. Pharmacol. pmid:3117063
Kashfi K and Rigas B Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention. 2005 Biochem. Pharmacol. pmid:15949789
Clark DL and Queener SF Effects of diabetes mellitus on renal fatty acid activation and desaturation. 1985 Biochem. Pharmacol. pmid:4074391
Blond JP et al. Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. 1989 Biochem. Pharmacol. pmid:2764996
Hudson EA et al. Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. 1993 Biochem. Pharmacol. pmid:8517859
Larsen LN et al. Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. 1998 Biochem. Pharmacol. pmid:9514074
Goldmacher VS Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. 1983 Biochem. Pharmacol. pmid:6189496
Masini E et al. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. 1990 Biochem. Pharmacol. pmid:1690007
Vaughan PF and Ball SG The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. 1990 Biochem. Pharmacol. pmid:1968340
Castańeda-Hernández G Presence of endogenous digitalis-like activity in mammalian heart not due to fatty acids. 1987 Biochem. Pharmacol. pmid:3036154
Reynolds CH Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. 1988 Biochem. Pharmacol. pmid:3144281
Murakami A et al. New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages. 2005 Biochem. Pharmacol. pmid:16143312
Altmann R et al. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. 2007 Biochem. Pharmacol. pmid:17604003