Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
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Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Girón MD et al. | Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. | 1990 | Biochim. Biophys. Acta | pmid:2369586 |
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| Lipids and multiple sclerosis. | 1990 | Lancet | pmid:1973215 | |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
| Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Laugier C et al. | Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1645959 |
| Saddik M and Lopaschuk GD | The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. | 1991 | Biochim. Biophys. Acta | pmid:1932104 |
| Hrboticky N et al. | Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. | 1991 | Am. J. Clin. Nutr. | pmid:1989416 |
| Kearns EV et al. | The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). | 1991 | Arch. Biochem. Biophys. | pmid:1989527 |
| Muakkassa FF et al. | Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. | 1991 | Arch Surg | pmid:1992995 |
| Earles SM et al. | Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. | 1991 | Biochim. Biophys. Acta | pmid:1998735 |
| Hubbard NE and Erickson KL | Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. | 1991 | Cancer Lett. | pmid:1998946 |
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| Beyers EC and Emken EA | Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. | 1991 | Biochim. Biophys. Acta | pmid:2029547 |
| Gerwick WH et al. | Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. | 1991 | Arch. Biochem. Biophys. | pmid:1929410 |
| Ip C et al. | Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. | 1991 | Cancer Res. | pmid:1933874 |
| Fukuzawa K et al. | Peroxide-dependent and -independent lipid peroxidations catalyzed by chelated iron. | 1991 | Arch. Biochem. Biophys. | pmid:1656881 |
| Butovich IA et al. | The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. | 1991 | Eur. J. Biochem. | pmid:2065670 |
| Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
| Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
| Izumi T et al. | Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. | 1991 | Eur. J. Biochem. | pmid:1662607 |
| Stein Y et al. | Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. | 1991 | Biochim. Biophys. Acta | pmid:2054378 |
| Nagao M et al. | Effect of extracellular fatty acids on lipid metabolism in cultured rabbit articular chondrocytes. | 1991 | J. Orthop. Res. | pmid:1901357 |
| Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
| Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
| Liu B et al. | Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. | 1991 | Cell Regul. | pmid:1801923 |
| Katan MB et al. | Biological markers of dietary intake, with emphasis on fatty acids. | 1991 | Ann. Nutr. Metab. | pmid:1776820 |
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| Pourplanche C et al. | Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. | 1991 | Anal. Biochem. | pmid:1789419 |
| Reaven P et al. | Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. | 1991 | Am. J. Clin. Nutr. | pmid:1897476 |
| Jyothirmayi N and Ramadoss CS | Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. | 1991 | Biochim. Biophys. Acta | pmid:1903659 |
| Leyton J et al. | Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin. | 1991 | Cancer Res. | pmid:1899048 |
| Iacono JM and Dougherty RM | Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. | 1991 | Am. J. Clin. Nutr. | pmid:1900384 |
| MacÃas P et al. | Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. | 1991 | Biochim. Biophys. Acta | pmid:1903070 |
| Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
| Thomson AB et al. | Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. | 1991 | Biochim. Biophys. Acta | pmid:1854796 |
| Semplicini A et al. | Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. | 1991 | J Hypertens Suppl | pmid:1818979 |
| Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
| Bell JG et al. | High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. | 1991 | J. Nutr. | pmid:1861166 |
| James DR et al. | Increased susceptibility to peroxide-induced haemolysis with normal vitamin E concentrations in cystic fibrosis. | 1991 | Clin. Chim. Acta | pmid:1819470 |
| Nègre-Salvayre A et al. | Additional antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like systems are potentiated by rutin. | 1991 | Pharmacology | pmid:1652140 |
| Owen S et al. | Evidence of free-radical activity in asthma. | 1991 | N. Engl. J. Med. | pmid:1857396 |
| Chan JK et al. | Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. | 1991 | Am. J. Clin. Nutr. | pmid:1673589 |
| Dyer JR and Greenwood CE | Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. | 1991 | J. Neurochem. | pmid:1673995 |
| Biagi PL et al. | Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. | 1991 | Biochim. Biophys. Acta | pmid:1674661 |