Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
Jones RE | A hypothesis for early intervention in SIDS. | 1994 | Clin Pediatr (Phila) | pmid:7813148 |
López-Nicolás JM et al. | An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. | 1994 | Anal. Biochem. | pmid:7810887 |
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Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
Schmitt A et al. | Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. | 1995 | Biochim. Biophys. Acta | pmid:7786889 |
Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
Jones RE | A common factor for cardiac or respiratory failure in SIDS. | 1995 | Clin Pediatr (Phila) | pmid:7774147 |
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Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
López-Nicolás JM et al. | Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. | 1995 | Biochem. J. | pmid:7755559 |
Welsch CW | Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. | 1995 | Free Radic. Biol. Med. | pmid:7750800 |
Leis HJ et al. | On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. | 1995 | Br. J. Pharmacol. | pmid:7735686 |
Campbell FM et al. | Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733952 |
Angerman-Stewart JA et al. | Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. | 1995 | Arch. Biochem. Biophys. | pmid:7733666 |
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Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Umezawa M et al. | Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). | 1995 | Brain Res. | pmid:7712178 |
Jiang WG et al. | Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. | 1995 | Br. J. Cancer | pmid:7710939 |
Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
van Greevenbroek MM et al. | Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. | 1995 | J. Lipid Res. | pmid:7706938 |
Shi X et al. | Silica radical-induced DNA damage and lipid peroxidation. | 1994 | Environ. Health Perspect. | pmid:7705289 |
Sud'ina GF et al. | Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. | 1993 | FEBS Lett. | pmid:7689063 |
Bailey JM et al. | Dietary linoleic acid in alcohol-induced liver cirrhosis. | 1995 | Biochem. Soc. Trans. | pmid:7672270 |
Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
Sakai T et al. | A lipid peroxidation-derived aldehyde, 4-hydroxy-2-nonenal and omega 6 fatty acids contents in meats. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7670203 |
van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |
Khan MF et al. | Hematopoietic toxicity of linoleic acid anilide: importance of aniline. | 1995 | Fundam Appl Toxicol | pmid:7665006 |
Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
Laneuville O et al. | Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. | 1995 | J. Biol. Chem. | pmid:7642610 |
Rao GN et al. | Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. | 1995 | J. Clin. Invest. | pmid:7635978 |
Appel MJ and Woutersen RA | Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. | 1995 | Cancer Lett. | pmid:7634246 |
Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
Guo L et al. | Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. | 1995 | Free Radic. Biol. Med. | pmid:7628726 |
Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
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van der Heijdt LM et al. | Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. | 1995 | Eur. J. Biochem. | pmid:7628469 |
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Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
Norman HA et al. | Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. | 1995 | FEBS Lett. | pmid:7615067 |
Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
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Kurushima H et al. | Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. | 1995 | Atherosclerosis | pmid:7605390 |
van de Sandt JJ et al. | Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. | 1995 | Fundam Appl Toxicol | pmid:7601324 |
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Rodier M et al. | Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in NIDDM with secondary failure to oral antidiabetic agents. | 1995 | Diabetes Res. Clin. Pract. | pmid:7587908 |
Greco AV et al. | Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. | 1995 | Clin. Chim. Acta | pmid:7586583 |
Jiang WG et al. | Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). | 1995 | Cancer Res. | pmid:7585549 |
Nakayama T et al. | Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575511 |
Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
Shintani T et al. | Recognition system for dietary fatty acids in the rat small intestine. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7549092 |
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Campbell FM and Dutta-Roy AK | Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. | 1995 | FEBS Lett. | pmid:7498505 |
Bondy SC and Marwah S | Stimulation of synaptosomal free radical production by fatty acids: relation to esterification and to degree of unsaturation. | 1995 | FEBS Lett. | pmid:7498480 |
Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
Groscolas R et al. | Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. | 1995 | Nutr Cancer | pmid:7491300 |
Johanning GL and Lin TY | Unsaturated fatty acid effects on human breast cancer cell adhesion. | 1995 | Nutr Cancer | pmid:7491298 |
Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
Iwase H et al. | pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488065 |
Kerner J et al. | Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. | 1995 | Am. J. Physiol. | pmid:7485605 |
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