Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Nanji AA and Narod S | Multiple sclerosis, latitude and dietary fat: is pork the missing link? | 1986 | Med. Hypotheses | pmid:3638477 |
Boberg M et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1986 | Eur. J. Clin. Invest. | pmid:2938965 |
Orchard S et al. | Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis. | 1986 | Arch Dermatol | pmid:2942115 |
May V and Eipper BA | Long term culture of primary rat pituitary adrenocorticotropin/endorphin-producing cells in serum-free medium. | 1986 | Endocrinology | pmid:3004908 |
Murphy MG | Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma. | 1986 | J. Neurochem. | pmid:3011993 |
Skogh M | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids) | 1986 | J. Am. Acad. Dermatol. | pmid:3013957 |
Alexander JW et al. | The importance of lipid type in the diet after burn injury. | 1986 | Ann. Surg. | pmid:3015058 |
Yamamoto T et al. | Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3015226 |
Kääpä P et al. | Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. | 1986 | Am. J. Obstet. Gynecol. | pmid:3089014 |
Youyou A et al. | Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. | 1986 | J. Neurochem. | pmid:3940283 |
Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
Nijssen JG and van den Bosch H | Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3947653 |
Kryvi H et al. | Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. | 1986 | Biochim. Biophys. Acta | pmid:3947675 |
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Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
Riemersma RA et al. | Linoleic acid content in adipose tissue and coronary heart disease. | 1986 | Br Med J (Clin Res Ed) | pmid:3087455 |
Wander RC and Berdanier CD | Effects of type of dietary fat and carbohydrate on gluconeogenesis in isolated hepatocytes from BHE rats. | 1986 | J. Nutr. | pmid:3091787 |
Hansen HS et al. | Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. | 1986 | Biochim. Biophys. Acta | pmid:3092868 |
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Kanazawa K et al. | The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3768385 |
Jensen GE and Clausen J | Glutathione peroxidase activity, associated enzymes and substrates in blood cells from patients with multiple sclerosis--effects of antioxidant supplementation. | 1986 | Acta Pharmacol Toxicol (Copenh) | pmid:3776606 |
Hennig B et al. | Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. | 1986 | Arch. Biochem. Biophys. | pmid:3729421 |
Parsons HG et al. | Modulation of human erythrocyte shape and fatty acids by diet. | 1986 | Biochim. Biophys. Acta | pmid:3741859 |
Utermohlen V and Tucker MA | Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. | 1986 | Proc Nutr Soc | pmid:3797410 |
Hajarine M and Lagarde M | Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. | 1986 | Biochim. Biophys. Acta | pmid:3719006 |
Hansen HS and Jensen B | Urinary excretion of arginine-vasopressin and prostaglandin E2 in essential fatty acid-deficient rats after oral supplementation with unsaturated fatty acid esters. | 1986 | J. Nutr. | pmid:3080561 |
Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
Nijssen JG and van den Bosch H | Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3081034 |
Lee SH and Clandinin MT | Effect of dietary fat on the utilization of fatty acids by myocardial tissue in the rat. | 1986 | J. Nutr. | pmid:3794820 |
Morson LA and Clandinin MT | Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. | 1986 | J. Nutr. | pmid:2879899 |
Andre JC and Funk MO | Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. | 1986 | Anal. Biochem. | pmid:3101541 |
Heleniak EP and Lamola SW | A new prostaglandin disturbance syndrome in schizophrenia: delta-6-pyroluria. | 1986 | Med. Hypotheses | pmid:3520252 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Koletzko B et al. | Comparison of fatty acid composition of plasma lipid fractions in well-nourished Nigerian and German infants and toddlers. | 1986 Jul-Aug | J. Pediatr. Gastroenterol. Nutr. | pmid:3090220 |
Lester LA et al. | Supplemental parenteral nutrition in cystic fibrosis. | 1986 May-Jun | JPEN J Parenter Enteral Nutr | pmid:3086588 |
Young MR et al. | Stimulation of hematopoiesis and bone marrow suppressor cells by the subcutaneous injection of linoleic acid. | 1987 | Cell. Immunol. | pmid:2953447 |
Tilvis RS et al. | Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. | 1987 | Atherosclerosis | pmid:3619988 |
Strauss JS et al. | The effect of 13-cis-retinoic acid on sebaceous glands. | 1987 | Arch Dermatol | pmid:2960273 |
Melton JL et al. | Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. | 1987 | Biochim. Biophys. Acta | pmid:3651483 |
Dupont J | Essential fatty acids and prostaglandins. | 1987 | Prev Med | pmid:3628199 |
Steinberg WM et al. | Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency. | 1987 | Pancreas | pmid:3628223 |
Kromhout D et al. | Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol. | 1987 | Atherosclerosis | pmid:3632757 |
Berlin E et al. | Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men. | 1987 | Atherosclerosis | pmid:3632760 |
Kissil GW et al. | Capacity of the European eel (Anguilla anguilla) to elongate and desaturate dietary linoleic acid. | 1987 | J. Nutr. | pmid:3114442 |
Field EJ and Joyce G | Duchenne muscular dystrophy: do both parents contribute genetically to the disease? | 1987 | J. Neurol. Sci. | pmid:3126270 |
Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
Wertz PW et al. | Essential fatty acids and epidermal integrity. | 1987 | Arch Dermatol | pmid:3310912 |
Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
Walstra P et al. | Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:3115302 |
Colard O et al. | Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. | 1987 | Biochim. Biophys. Acta | pmid:3115303 |
Taylor AJ et al. | An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus. | 1987 | Clin. Chem. | pmid:3119255 |
Murphy MG et al. | Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells. | 1987 | Biochem. Pharmacol. | pmid:2825714 |
Mikhailidis DP et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1987 | Eur. J. Clin. Invest. | pmid:3106056 |
Bomalaski JS et al. | Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. | 1987 | Biochem. Pharmacol. | pmid:3117063 |
McLennan PL et al. | Dietary lipid modulation of myocardial beta-adrenergic mechanisms, Ca2+-dependent automaticity, and arrhythmogenesis in the marmoset. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2444777 |
Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
Ludwig P et al. | A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes. | 1987 | Eur. J. Biochem. | pmid:3117544 |
Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
Griffin JF et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material. | 1987 | Clin. Chim. Acta | pmid:3568417 |
Tay SK et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells. | 1987 | Clin. Chim. Acta | pmid:3568418 |
Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
Quik M | Evidence for an involvement of membrane lipids in the control of neuronal nicotinic receptor function using bungarotoxin II-S1. | 1987 | J. Neurochem. | pmid:3106571 |
Kaneko T et al. | Lethal effects of a linoleic acid hydroperoxide and its autoxidation products, unsaturated aliphatic aldehydes, on human diploid fibroblasts. | 1987 | Chem. Biol. Interact. | pmid:3664790 |
Das UN et al. | Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro. | 1987 | Free Radic. Biol. Med. | pmid:3040539 |
Nilsson A et al. | Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. | 1987 | Am. J. Physiol. | pmid:3109253 |
Fisher M et al. | Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients. | 1987 | Acta Neurol. Scand. | pmid:3687373 |
Ashida H et al. | Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:3688880 |
Vrignaud P and Robert J | Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. | 1987 | Biochim. Biophys. Acta | pmid:2886153 |
Willett WC et al. | Dietary fat and the risk of breast cancer. | 1987 | N. Engl. J. Med. | pmid:3785347 |
Jensen E et al. | Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. | 1987 | Biochim. Biophys. Acta | pmid:3790613 |
del Nido PJ et al. | Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. | 1987 | Circulation | pmid:2959398 |
Sani BP et al. | Interference of retinoic acid binding to its binding protein by omega-6 fatty acids. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820396 |
Emken EA et al. | Metabolism of cis-12-octadecenoic acid and trans-9,trans-12-octadecadienoic acid and their influence on lipogenic enzyme activities in mouse liver. | 1987 | Biochim. Biophys. Acta | pmid:3580379 |
Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
Mackie BS et al. | Melanoma and dietary lipids. | 1987 | Nutr Cancer | pmid:3110746 |
Cunnane SC | Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032013 |
Haines KA et al. | The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. | 1987 | Biochem. J. | pmid:3032161 |
Hagve TA and Christophersen BO | Sex-related differences in desaturation and chain elongation of essential fatty acids studied in isolated rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3607076 |
Watkins BA and Kratzer FH | Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. | 1987 | Poult. Sci. | pmid:3452223 |
Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
McKinney M | Blockade of receptor-mediated cyclic GMP formation by hydroxyeicosatetraenoic acid. | 1987 | J. Neurochem. | pmid:3037024 |
Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
Croft KD et al. | Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:2822134 |
Berge RK et al. | Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:2880562 |
Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
Coté GG and Brody S | Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. | 1987 | Biochim. Biophys. Acta | pmid:2889471 |
Hubbard NE and Erickson KL | Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid. | 1987 | Cancer Res. | pmid:3677068 |
Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
Setty BN et al. | 13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3113422 |
Wan JM and Grimble RF | Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin. | 1987 | Clin. Sci. | pmid:3545648 |
Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |
Arca M et al. | Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. | 1987 | Am. J. Clin. Nutr. | pmid:3604961 |