Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
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Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
| Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
| Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
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| Uotila P et al. | Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3116200 |
| Mikhailidis DP et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1987 | Eur. J. Clin. Invest. | pmid:3106056 |
| Stocker R et al. | Bilirubin is an antioxidant of possible physiological importance. | 1987 | Science | pmid:3029864 |
| Griffin JF et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material. | 1987 | Clin. Chim. Acta | pmid:3568417 |
| Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
| Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
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| Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
| Wan JM and Grimble RF | Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin. | 1987 | Clin. Sci. | pmid:3545648 |
| Nugteren DH and Kivits GA | Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. | 1987 | Biochim. Biophys. Acta | pmid:3113487 |
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| Perez RV et al. | Dietary immunoregulation of transfusion-induced immunosuppression. | 1988 | Transplantation | pmid:3258077 |
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| Perisho K et al. | Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. | 1988 | J. Invest. Dermatol. | pmid:2964492 |
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| Solakivi T et al. | Plasma apolipoprotein B in middle-aged Finnish men. Evidence for a regional gradient of apo B and lack of negative correlation between apo B and dietary linoleate in hyperapobetalipoproteinemia. | 1988 | Atherosclerosis | pmid:3214459 |
| Schächtele C et al. | Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831891 |
| Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
| Brasitus TA and Dudeja PK | Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. | 1988 | Biochim. Biophys. Acta | pmid:3128322 |
| Nilsson A and Landin B | Metabolism of chylomicron arachidonic and linoleic acid in the rat. | 1988 | Biochim. Biophys. Acta | pmid:3128335 |
| Cutts JL and Melnykovych G | Defective utilization of cholesterol esters from low-density lipoprotein in a human acute lymphoblastic leukemia T cell line. | 1988 | Biochim. Biophys. Acta | pmid:3260113 |
| Venkatraman JT and Clandinin MT | Ribonucleic acid efflux from isolated mouse liver nuclei is altered by diet and genotypically determined change in nuclear envelope composition. | 1988 | Biochim. Biophys. Acta | pmid:2452656 |
| MacKenzie LW et al. | Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. | 1988 | Am. J. Obstet. Gynecol. | pmid:3144917 |
| Wooten MW and Wrenn RW | Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2454109 |
| Benadé AJ et al. | Plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined Vervet monkeys. | 1988 | Atherosclerosis | pmid:3145748 |
| Sauer LA and Dauchy RT | Identification of linoleic and arachidonic acids as the factors in hyperlipemic blood that increase [3H]thymidine incorporation in hepatoma 7288CTC perfused in situ. | 1988 | Cancer Res. | pmid:3130186 |
| Salafsky B et al. | Schistosoma mansoni: analysis of cercarial transformation methods. | 1988 | Exp. Parasitol. | pmid:2458958 |
| Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
| Slinger AJ and Isaac RE | Synthesis of apolar ecdysone esters by ovaries of the cockroach Periplaneta americana. | 1988 | Gen. Comp. Endocrinol. | pmid:3371652 |
| Garg ML et al. | Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. | 1988 | Biochim. Biophys. Acta | pmid:2844278 |
| Laposata M et al. | Icosanoid production can be decreased without alterations in cellular arachidonate content or enzyme activities required for arachidonate release and icosanoid synthesis. | 1988 | J. Biol. Chem. | pmid:2893800 |
| Grant HW et al. | Dietary linoleic acid, gastric acid, and prostaglandin secretion. | 1988 | Gastroenterology | pmid:3162220 |
| Schepp W et al. | Modulation of rat gastric mucosal prostaglandin E2 release by dietary linoleic acid: effects on gastric acid secretion and stress-induced mucosal damage. | 1988 | Gastroenterology | pmid:3163660 |
| Wright JR et al. | Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3045812 |
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| Albro PW et al. | Comparison of the effects of carbon tetrachloride and of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the disposition of linoleic acid in rat liver in vitro. | 1988 | Chem. Biol. Interact. | pmid:3135123 |
| Rimola A et al. | Prostaglandin precursor fatty acids in cirrhosis with ascites: effect of linoleic acid infusion in functional renal failure. | 1988 | Clin. Sci. | pmid:3135142 |
| Staats DA et al. | Effects of tocopherol depletion on the regional differences in adrenal microsomal lipid peroxidation and steroid metabolism. | 1988 | Endocrinology | pmid:3135177 |
| Craven PA and DeRubertis FR | Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. | 1988 | Gastroenterology | pmid:3135225 |
| Nakagawa Y and Waku K | Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3142466 |
| Rafael J et al. | Effect of dietary linoleic acid and essential fatty acid deficiency on resting metabolism, nonshivering thermogenesis and brown adipose tissue in the rat. | 1988 | J. Nutr. | pmid:3367242 |
| Simpson LO | The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis. | 1988 | Med. Hypotheses | pmid:3367811 |
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| Das UN | Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144272 |
| Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
| Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
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| Bourre JM et al. | The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. | 1989 | J. Nutr. | pmid:2576038 |
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