Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Acute Coronary Syndrome D054058 11 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Restenosis D023903 10 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Circoviridae Infections D018173 2 associated lipids
Glucose Intolerance D018149 13 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Hyperpigmentation D017495 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Helicobacter Infections D016481 21 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Tuberculosis D014376 20 associated lipids
Thrombosis D013927 49 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Seizures D012640 87 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pain D010146 64 associated lipids
Otitis Externa D010032 8 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Melanosis D008548 4 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Lymphopenia D008231 2 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Diseases D008107 31 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia D007938 74 associated lipids
Lactose Intolerance D007787 2 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Kidney Diseases D007674 29 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Heart Failure D006333 36 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Glioma D005910 112 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Disease D003327 70 associated lipids
Constipation D003248 8 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colitis D003092 69 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Body Weight D001835 333 associated lipids
Birth Weight D001724 23 associated lipids
Arteriosclerosis D001161 86 associated lipids
Aortic Diseases D001018 11 associated lipids
Olfaction Disorders D000857 17 associated lipids
Anorexia D000855 8 associated lipids
Alopecia D000505 14 associated lipids
Adenocarcinoma D000230 166 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
de Vogel-van den Bosch HM et al. A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18356535
Bionaz M et al. Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids. 2008 J. Dairy Sci. pmid:18565938
Netsu S et al. Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis. 2008 Fertil. Steril. pmid:18054352
Diniz YS et al. Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets. 2008 Eur. J. Pharmacol. pmid:18054909
Vögler O et al. Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. 2008 Int J Obes (Lond) pmid:18059405
Ogata K et al. Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. 2008 J. Pharm. Pharmacol. pmid:18088500
Ruths M et al. Friction of fatty acids in nanometer-sized contacts of different adhesive strength. 2008 Langmuir pmid:18085802
Dreisbach AW et al. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. 2008 Hypertension pmid:18227407
Kim T et al. Pharmacokinetics of formulated tenoxicam transdermal delivery systems. 2008 J. Pharm. Pharmacol. pmid:18088513
Gaillard D et al. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. 2008 FASEB J. pmid:18162488
Aronis A et al. Lipotoxic effects of triacylglycerols in J774.2 macrophages. 2008 Nutrition pmid:18165129
Garelnabi M et al. Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. 2008 Atherosclerosis pmid:18243209
Jang A et al. Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. 2008 Chem. Biol. Interact. pmid:18571153
Pinnick KE et al. Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. 2008 Obesity (Silver Spring) pmid:18239594
Eder E et al. Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. 2008 Mutat. Res. pmid:18602860
Meguid NA et al. Role of polyunsaturated fatty acids in the management of Egyptian children with autism. 2008 Clin. Biochem. pmid:18582451
Burenjargal M and Totani N Effects of thermally processed oil on weight loss in rats. 2008 J Oleo Sci pmid:18685228
Saez G et al. Is the hepatic metabolism of glucose and linoleic acid influenced by species in overfed ducks? 2008 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:18687407
Miura K et al. Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]. 2008 Hypertension pmid:18606902
Ogorodnikova AV et al. Detection of divinyl ether synthase in Lily-of-the-Valley (Convallaria majalis) roots. 2008 Phytochemistry pmid:18952245
Stratford JM et al. Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18635450
Nagelin MH et al. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18635820
Tao X et al. GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. 2008 Anal Bioanal Chem pmid:18622754
Koussoroplis AM et al. From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. 2008 Lipids pmid:18335265
Granvogl M et al. Development of a stable isotope dilution assay for the quantitation of glycidamide and its application to foods and model systems. 2008 J. Agric. Food Chem. pmid:18624425
Alghazeer R et al. Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). 2008 Toxicol. Lett. pmid:18625293
Lukovac S et al. Essential fatty acid deficiency in mice impairs lactose digestion. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18653724
Fagali N and Catalá A Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH techniques. 2008 Biophys. Chem. pmid:18656302
Gülçin I In vitro prooxidant effect of caffeine. 2008 J Enzyme Inhib Med Chem pmid:18341268
Minami Y et al. Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. 2008 Free Radic. Res. pmid:18344113
Horowitz Brown S et al. Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. 2008 Appl. Environ. Microbiol. pmid:18658287
Zhu H et al. 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. 2008 Int. J. Cancer pmid:18785202
Chicco AJ et al. Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. 2008 Hypertension pmid:18663155
de Virville JD et al. Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. 2008 Planta pmid:18663470
Zhao ZY et al. Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.). 2008 J Zhejiang Univ Sci B pmid:18763301
Wang L et al. Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. 2008 Chem. Biol. Interact. pmid:18155686
Chavarro JE et al. A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. 2008 Cancer Epidemiol. Biomarkers Prev. pmid:18199715
Yara A et al. Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. 2008 Biochem. Biophys. Res. Commun. pmid:18373976
Jäger AK et al. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. 2008 Phytother Res pmid:18389471
Chou YC et al. Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. 2008 Phytother Res pmid:18398904
Swida A et al. Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. 2008 Biochem. J. pmid:18402555
Gallardo E et al. Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. 2008 J. Agric. Food Chem. pmid:18386901
Morawicki RO and Beelman RB Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. 2008 J. Food Sci. pmid:18387089
Kwon JI et al. Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. 2008 J Med Food pmid:18361731
Tian Z et al. Preparation and evaluation of a linoleic-acid-modified amphiphilic polypeptide copolymer as a carrier for controlled drug release. 2008 Biomed Mater pmid:19029601
Warensjö E et al. Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. 2008 Nutr Metab Cardiovasc Dis pmid:18367385
Khodadadi I et al. Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. 2008 Arch Iran Med pmid:18154422
Ueda Y et al. Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. 2008 Nutr Res pmid:19083414
Lopes PA et al. Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. 2008 Nutr Res pmid:19083449
Hoashi S et al. Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle. 2008 BMC Genet. pmid:19077218
Higashi-Okai K et al. Potent antioxidant and radical-scavenging activities of traditional Japanese cereal grains. 2008 J. UOEH pmid:19086696
Safaa HM et al. Effects of the levels of methionine, linoleic Acid, and added fat in the diet on productive performance and egg quality of brown laying hens in the late phase of production. 2008 Poult. Sci. pmid:18648054
Zanoni S et al. Growth kinetics on oligo- and polysaccharides and promising features of three antioxidative potential probiotic strains. 2008 J. Appl. Microbiol. pmid:18778294
Crean C et al. Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals. 2008 Chem. Res. Toxicol. pmid:18159932
Bueno AA et al. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. 2008 Pflugers Arch. pmid:17717684
Theve EJ et al. Sex hormone influence on hepatitis in young male A/JCr mice infected with Helicobacter hepaticus. 2008 Infect. Immun. pmid:18559427
Tepe B Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata (Jacq), Salvia staminea (Montbret & Aucher ex Bentham) and Salvia verbenaca (L.) from Turkey. 2008 Bioresour. Technol. pmid:17531471
Xanthopoulou MN et al. Biological studies of new organotin(IV) complexes of thioamide ligands. 2008 Eur J Med Chem pmid:17509733
Al-Turkmani MR et al. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036797
Chechetkin IR et al. Regio- and stereospecificity of recombinant soybean lipoxygenase-2. 2007 Jul-Aug Dokl. Biochem. Biophys. pmid:17933341
Ardestani A and Yazdanparast R Inhibitory effects of ethyl acetate extract of Teucrium polium on in vitro protein glycoxidation. 2007 Food Chem. Toxicol. pmid:17673348
Labadaridis I et al. Linoleic and arachidonic acid in perinatal asphyxia and prematurity. 2007 J. Matern. Fetal. Neonatal. Med. pmid:17674280
Kummerow FA et al. Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. 2007 Prostaglandins Other Lipid Mediat. pmid:17991616
Roman-Nunez M et al. Influence of sodium glycocholate on production of conjugated linoleic acid by cells of Lactobacillus reuteri ATCC 55739. 2007 J. Food Sci. pmid:17995782
Yuan S and Chang SK Selected odor compounds in soymilk as affected by chemical composition and lipoxygenases in five soybean materials. 2007 J. Agric. Food Chem. pmid:17227075
Ye P et al. The alteration of plasminogen activator inhibitor-1 expression by linoleic acid and fenofibrate in HepG2 cells. 2007 Blood Coagul. Fibrinolysis pmid:17179821
Javadi M et al. The influence of dietary linoleic and alpha-linolenic acid on body composition and the activities of key enzymes of hepatic lipogenesis and fatty acid oxidation in mice. 2007 J Anim Physiol Anim Nutr (Berl) pmid:17217386
Gülçin I et al. Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. 2007 Phytother Res pmid:17221941
Agostoni C et al. Double-blind, placebo-controlled trial comparing effects of supplementation of two micronutrient sprinkles on fatty acid status in Cambodian infants. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:17204967
Todorov VT et al. Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression. 2007 Hypertension pmid:17785633
Rosa A et al. Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum. 2007 Chem. Biol. Interact. pmid:17194458
Duan X et al. Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention. 2007 Molecules pmid:17851428
Gillilan RE et al. Structural basis for activation of fatty acid-binding protein 4. 2007 J. Mol. Biol. pmid:17761196
Goupy P et al. Dietary antioxidants as inhibitors of the heme-induced peroxidation of linoleic acid: mechanism of action and synergism. 2007 Free Radic. Biol. Med. pmid:17697938
Sum CS et al. Identification of residues important for agonist recognition and activation in GPR40. 2007 J. Biol. Chem. pmid:17699519
Aburai N et al. Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. 2007 Biosci. Biotechnol. Biochem. pmid:17690455
Muzio G et al. PPARalpha and PP2A are involved in the proapoptotic effect of conjugated linoleic acid on human hepatoma cell line SK-HEP-1. 2007 Int. J. Cancer pmid:17691108
Breza JM et al. Monosodium glutamate but not linoleic acid differentially activates gustatory neurons in the rat geniculate ganglion. 2007 Chem. Senses pmid:17693416
Sclafani A et al. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17804586
Walkowiak J et al. Polyunsaturated fatty acids in cystic fibrosis are related to nutrition and clinical expression of the disease. 2007 J. Pediatr. Gastroenterol. Nutr. pmid:18030219
Nam IS and Garnsworthy PC Biohydrogenation of linoleic acid by rumen fungi compared with rumen bacteria. 2007 J. Appl. Microbiol. pmid:17714387
Or-Rashid MM et al. Fatty acid composition of ruminal bacteria and protozoa, with emphasis on conjugated linoleic acid, vaccenic acid, and odd-chain and branched-chain fatty acids. 2007 J. Anim. Sci. pmid:17145972
AbouZid S and Orihara Y Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. 2007 Planta Med. pmid:17973205
Lin D et al. Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. 2007 J. Org. Chem. pmid:17979284
Al-Khalifa A et al. Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17122327
Uehara Y et al. Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element. 2007 Atherosclerosis pmid:16730733
Schweiger D et al. Inducible expression of 15-lipoxygenase-2 and 8-lipoxygenase inhibits cell growth via common signaling pathways. 2007 J. Lipid Res. pmid:17164225
Degner SC et al. Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. 2007 Nutr Cancer pmid:18001219
Almendingen K et al. Familial adenomatous polyposis patients have high levels of arachidonic acid and docosahexaenoic acid and low levels of linoleic acid and alpha-linolenic acid in serum phospholipids. 2007 Int. J. Cancer pmid:17096349
Yoneda T et al. The palatability of corn oil and linoleic acid to mice as measured by short-term two-bottle choice and licking tests. 2007 Physiol. Behav. pmid:17459430
Laidler P et al. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? 2007 Arch. Biochem. Biophys. pmid:17466258
Cao ZP et al. Intracerebroventricular administration of conjugated linoleic acid (CLA) inhibits food intake by decreasing gene expression of NPY and AgRP. 2007 Neurosci. Lett. pmid:17466453
Yin D et al. Construction of a high-efficient expression vector of Delta12 fatty acid desaturase in peanut and its prokaryotical expression. 2007 J Genet Genomics pmid:17469780
Pittman D et al. Chorda tympani nerve transection impairs the gustatory detection of free fatty acids in male and female rats. 2007 Brain Res. pmid:17428454
Dufour C and Loonis M Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. 2007 Biochim. Biophys. Acta pmid:17428609
Gaquerel E et al. Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. 2007 Biochim. Biophys. Acta pmid:17428728
Kim JH et al. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. 2007 Poult. Sci. pmid:17495090
Lindenmeier M et al. A novel method to measure both the reductive and the radical scavenging activity in a linoleic acid model system. 2007 Mol Nutr Food Res pmid:17680718
Cadirci E et al. Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. 2007 Chem. Biol. Interact. pmid:17681286
Risé P et al. Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. 2007 Eur. J. Pharmacol. pmid:17655842