Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Acute Coronary Syndrome D054058 11 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Restenosis D023903 10 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Circoviridae Infections D018173 2 associated lipids
Glucose Intolerance D018149 13 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Hyperpigmentation D017495 11 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Helicobacter Infections D016481 21 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Tuberculosis D014376 20 associated lipids
Thrombosis D013927 49 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Seizures D012640 87 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pain D010146 64 associated lipids
Otitis Externa D010032 8 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Melanosis D008548 4 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Lymphopenia D008231 2 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Diseases D008107 31 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia D007938 74 associated lipids
Lactose Intolerance D007787 2 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Kidney Diseases D007674 29 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Heart Failure D006333 36 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Glioma D005910 112 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Coronary Disease D003327 70 associated lipids
Constipation D003248 8 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Colitis D003092 69 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Body Weight D001835 333 associated lipids
Birth Weight D001724 23 associated lipids
Arteriosclerosis D001161 86 associated lipids
Aortic Diseases D001018 11 associated lipids
Olfaction Disorders D000857 17 associated lipids
Anorexia D000855 8 associated lipids
Alopecia D000505 14 associated lipids
Adenocarcinoma D000230 166 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Kiliç T et al. Fatty acid composition of seeds of some species of Nepeta L. 2007 Nat. Prod. Res. pmid:17487620
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Scholljegerdes EJ et al. Fatty acid composition of plasma, medial basal hypothalamus, and uterine tissue in primiparous beef cows fed high-linoleate safflower seeds. 2007 J. Anim. Sci. pmid:17325123
Pérez-Matute P et al. Linoleic acid decreases leptin and adiponectin secretion from primary rat adipocytes in the presence of insulin. 2007 Lipids pmid:17647039
Segovia-Siapco G et al. Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. 2007 Public Health Nutr pmid:17261227
Shen SR et al. Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines. 2007 Mol Nutr Food Res pmid:17262883
Zhu X and Sayre LM Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. 2007 Redox Rep. pmid:17263908
Yano M et al. Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. 2007 Antimicrob. Agents Chemother. pmid:17420205
Ben-Shabat S et al. Conjugates of unsaturated fatty acids with propylene glycol as potentially less-irritant skin penetration enhancers. 2007 Drug Dev Ind Pharm pmid:18058312
Griel AE et al. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. 2007 Nutr J pmid:17227589
Markaverich BM et al. Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation. 2007 Environ. Health Perspect. pmid:18087590
Golfetto I et al. Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? 2007 Nutr Health pmid:18087864
Clément M et al. Whey-derived free fatty acids suppress the germination of Candida albicans in vitro. 2007 FEMS Yeast Res. pmid:17034417
Somparn P et al. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. 2007 Biol. Pharm. Bull. pmid:17202663
Yazdanparast R and Ardestani A In vitro antioxidant and free radical scavenging activity of Cyperus rotundus. 2007 J Med Food pmid:18158839
Güllçin I and Daştan A Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities. 2007 J Enzyme Inhib Med Chem pmid:18237020
Lin YH and Salem N Whole body distribution of deuterated linoleic and alpha-linolenic acids and their metabolites in the rat. 2007 J. Lipid Res. pmid:17876057
Willett WC The role of dietary n-6 fatty acids in the prevention of cardiovascular disease. 2007 J Cardiovasc Med (Hagerstown) pmid:17876199
LaRosa PC et al. Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. 2007 Physiol. Genomics pmid:17878318
Yuri M et al. Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. 2007 Histopathology pmid:17711445
Breiden B et al. Optimization of submerged keratinocyte cultures for the synthesis of barrier ceramides. 2007 Eur. J. Cell Biol. pmid:17714827
Shyamala BN et al. Studies on the antioxidant activities of natural vanilla extract and its constituent compounds through in vitro models. 2007 J. Agric. Food Chem. pmid:17715988
Polesel J et al. Nutrients intake and the risk of hepatocellular carcinoma in Italy. 2007 Eur. J. Cancer pmid:17719221
Koto T et al. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17724224
Sato I et al. Identification of COX inhibitors in the hexane extract of Japanese horse chestnut (Aesculus turbinata) seeds. 2007 J. Vet. Med. Sci. pmid:17675801
Barrett E et al. Rapid screening method for analyzing the conjugated linoleic acid production capabilities of bacterial cultures. 2007 Appl. Environ. Microbiol. pmid:17277221
Nam JW and Kappock TJ Cloning and transcriptional analysis of Crepis alpina fatty acid desaturases affecting the biosynthesis of crepenynic acid. 2007 J. Exp. Bot. pmid:17329262
Fang IM et al. Linoleic acid-induced expression of inducible nitric oxide synthase and cyclooxygenase II via p42/44 mitogen-activated protein kinase and nuclear factor-kappaB pathway in retinal pigment epithelial cells. 2007 Exp. Eye Res. pmid:17825288
Shah M et al. Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. 2007 Diabetes Care pmid:17804680
Jouany JP et al. Dynamic features of the rumen metabolism of linoleic acid, linolenic acid and linseed oil measured in vitro. 2007 Lipids pmid:17406930
Zhang JS et al. [Study on inhibitory effects of c9, t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway]. 2007 Zhonghua Yu Fang Yi Xue Za Zhi pmid:18399127
Nam IS and Garnsworthy PC Factors influencing biohydrogenation and conjugated linoleic acid production by mixed rumen fungi. 2007 J. Microbiol. pmid:17618224
Szachowicz-Petelska B et al. Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue. 2007 Mol. Cell. Biochem. pmid:16858511
Matta JA et al. TRPV1 is a novel target for omega-3 polyunsaturated fatty acids. 2007 J. Physiol. (Lond.) pmid:17038422
Tarnopolsky M et al. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. 2007 PLoS ONE pmid:17912368
Fujiyama Y et al. Butter feeding enhances TNF-alpha production from macrophages and lymphocyte adherence in murine small intestinal microvessels. 2007 J. Gastroenterol. Hepatol. pmid:17914958
Gakwaya R et al. Examining the collision-induced decomposition spectra of ammoniated triglycerides. III. The linoleate and arachidonate series. 2007 Rapid Commun. Mass Spectrom. pmid:17893948
Grechkin AN et al. Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoenoic acid in sunflower roots. 2007 Chembiochem pmid:17957816
Wallace RJ et al. Isomers of conjugated linoleic acids are synthesized via different mechanisms in ruminal digesta and bacteria. 2007 J. Lipid Res. pmid:17644775
Ben Bacha A et al. Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. 2007 Pancreas pmid:17895836
Maia MR et al. Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen. 2007 Antonie Van Leeuwenhoek pmid:17072533
Tunalier Z et al. Antioxidant, anti-inflammatory, anti-nociceptive activities and composition of Lythrum salicaria L. extracts. 2007 J Ethnopharmacol pmid:17125946
Cosgrove MC et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. 2007 Am. J. Clin. Nutr. pmid:17921406
Ito T et al. The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. 2007 Plant Cell pmid:17981996
Balesteros MR et al. Determination of olive oil acidity by CE. 2007 Electrophoresis pmid:17941122
Tannin-Spitz T et al. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. 2007 Biochem. Biophys. Res. Commun. pmid:17942079
Shin SC et al. Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. 2007 Pharm Dev Technol pmid:17963142
Takajo T et al. Feedback activation of ferrous 5-lipoxygenase during leukotriene synthesis by coexisting linoleic acid. 2007 J. Lipid Res. pmid:17337722
Hamam F and Shahidi F Acidolysis of tristearin with selected long-chain fatty acids. 2007 J. Agric. Food Chem. pmid:17288439
Mattes RD Effects of linoleic acid on sweet, sour, salty, and bitter taste thresholds and intensity ratings of adults. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17290007
Okuyama H et al. Omega3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome. 2007 World Rev Nutr Diet pmid:17167282
Ou L et al. Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. 2007 Biochem. Biophys. Res. Commun. pmid:17400188
Okuyama H et al. Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? 2007 World Rev Nutr Diet pmid:17167283
Okuyama H et al. Mechanisms by which dietary fats affect coronary heart disease mortality. 2007 World Rev Nutr Diet pmid:17167284
Liou YA et al. Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. 2007 J. Nutr. pmid:17374659
Okuyama H et al. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. 2007 World Rev Nutr Diet pmid:17167285
Koeduka T et al. Cloning of lipoxygenase genes from a cyanobacterium, Nostoc punctiforme, and its expression in Eschelichia coli. 2007 Curr. Microbiol. pmid:17375360
Mizushina Y et al. Inhibitory action of polyunsaturated fatty acids on IMP dehydrogenase. 2007 Biochimie pmid:17383068
Makrantonaki E and Zouboulis CC Testosterone metabolism to 5alpha-dihydrotestosterone and synthesis of sebaceous lipids is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes. 2007 Br. J. Dermatol. pmid:17300229
Zhu X and Sayre LM Long-lived 4-oxo-2-enal-derived apparent lysine michael adducts are actually the isomeric 4-ketoamides. 2007 Chem. Res. Toxicol. pmid:17305402
Mukherjee A et al. Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. 2007 Biochemistry pmid:17355126
Romero MM et al. The conjugated linoleic acid ester of estrone induces the mobilisation of fat in male Wistar rats. 2007 Naunyn Schmiedebergs Arch. Pharmacol. pmid:17387456
Ander BP et al. Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid. 2007 Cardiovasc. Res. pmid:17059813
Forsythe CE et al. Cholesterolaemic influence of palmitic acid in the sn-1, 3 v. the sn-2 position with high or low dietary linoleic acid in healthy young men. 2007 Br. J. Nutr. pmid:17391563
Pankiewicz E et al. Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section. 2007 Early Hum. Dev. pmid:17059872
Baylin A et al. alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. 2007 Am. J. Clin. Nutr. pmid:17284757
Lake SL et al. Effects of postpartum dietary fat and body condition score at parturition on plasma, adipose tissue, and milk fatty acid composition of lactating beef cows. 2007 J. Anim. Sci. pmid:17060413
Makena P and Chung KT Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species. 2007 Environ. Mol. Mutagen. pmid:17370336
Ay M et al. Antioxidant activity of Erica arborea. 2007 Fitoterapia pmid:17570611
Carpentier AC et al. Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17062840
Chalé-Rush A et al. Multiple routes of chemosensitivity to free fatty acids in humans. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17234892
Ghezzi S et al. Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. 2007 Lipids pmid:17551762
Vargas F et al. Photodegradation and in vitro phototoxicity of aceclofenac. 2007 Pharmazie pmid:17557739
Cazzolli R et al. Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle. 2007 Diabetologia pmid:17593346
Lauretani F et al. Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. 2007 Eur. J. Neurol. pmid:17594339
Kolar SS et al. Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. 2007 Cancer Res. pmid:17545640
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Bondia-Pons I et al. Determination of conjugated linoleic acid in human plasma by fast gas chromatography. 2007 J Chromatogr A pmid:17532324
Ren Y et al. Preparation of liquid-core nanocapsules from poly[(ethylene oxide)-co-glycidol] with multiple hydrophobic linoleates at an oil-water interface and its encapsulation of pyrene. 2007 Biomacromolecules pmid:17518441
Guo W et al. Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17519282
Fang Q et al. Etheno-DNA adduct formation in rats gavaged with linoleic acid, oleic acid and coconut oil is organ- and gender specific. 2007 Mutat. Res. pmid:17521682
Barla A et al. Screening of antioxidant activity of three Euphorbia species from Turkey. 2007 Fitoterapia pmid:17582698
Tejero I et al. A PM3/d specific reaction parameterization for iron atom in the hydrogen abstraction catalyzed by soybean lipoxygenase-1. 2007 J Comput Chem pmid:17274015
Egashira Y et al. Dietary protein level and dietary interaction affect quinolinic acid concentration in rats. 2007 Int J Vitam Nutr Res pmid:17896587
Sauer LA et al. Dietary factors and growth and metabolism in experimental tumors. 2007 J. Nutr. Biochem. pmid:17418560
Bongers ME et al. The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. 2007 Nutr J pmid:17428343
Subauste AR and Burant CF Role of FoxO1 in FFA-induced oxidative stress in adipocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17374693
Tanaka T et al. Metabolic pathway that produces essential fatty acids from polymethylene-interrupted polyunsaturated fatty acids in animal cells. 2007 FEBS J. pmid:17451430
Van Nieuwenhove CP et al. Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk. 2007 Lett. Appl. Microbiol. pmid:17451511
Li Z et al. Lipase-catalyzed esterification of conjugated linoleic acid with L-carnitine in solvent-free system and acetonitrile. 2007 Bioprocess Biosyst Eng pmid:17503088
Khatib S et al. An exogenous marker: a novel approach for the characterization of oxidative stress. 2007 Bioorg. Med. Chem. pmid:17407818
Pinna A et al. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. 2007 Cornea pmid:17413949
Bozzo F et al. Antiproliferative effect of conjugated linoleic acid in caco-2 cells: involvement of PPARgamma and APC/beta-catenin pathways. 2007 Chem. Biol. Interact. pmid:17632092
Gorjão R et al. Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. 2007 J. Lipid Res. pmid:17592174
Rosberg-Cody E et al. Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid. 2007 Microbiology (Reading, Engl.) pmid:17660413
Kumar S et al. Antioxidant profile of ethoxyquin and some of its S, Se, and Te analogues. 2007 J. Org. Chem. pmid:17602530
Dufour C et al. Inhibition of the peroxidation of linoleic acid by the flavonoid quercetin within their complex with human serum albumin. 2007 Free Radic. Biol. Med. pmid:17603933
Altmann R et al. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. 2007 Biochem. Pharmacol. pmid:17604003
Zeng YX et al. Comparative analysis of volatile components from Clematis species growing in China. 2007 Anal. Chim. Acta pmid:17606017
Hodge AM et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. 2007 Am. J. Clin. Nutr. pmid:17616780