Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kang J et al. | Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa. | 2011 | Plant Physiol. Biochem. | pmid:21215650 |
Park HG et al. | Production of conjugated linoleic acid (CLA) by Bifidobacterium breve LMC520 and its compatibility with CLA-producing rumen bacteria. | 2011 | J. Agric. Food Chem. | pmid:21192703 |
Lasa A et al. | Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. | 2011 | Nutrition | pmid:20619605 |
Tan B et al. | Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. | 2011 | J. Nutr. Biochem. | pmid:20619625 |
Shirakawa J et al. | Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. | 2011 | J. Biol. Chem. | pmid:21613229 |
Wang L et al. | Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. | 2011 | J. Endocrinol. | pmid:21565851 |
Gelhaus SL et al. | Cellular lipid extraction for targeted stable isotope dilution liquid chromatography-mass spectrometry analysis. | 2011 | J Vis Exp | pmid:22127066 |
Andreu I et al. | Probing lipid peroxidation by using linoleic acid and benzophenone. | 2011 | Chemistry | pmid:21793062 |
Cunnane SC and Guesnet P | Linoleic acid recommendations--A house of cards. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21963263 |
P Wrobel T et al. | Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. | 2011 | Analyst | pmid:22007352 |
Salleh WM et al. | Chemical compositions, antioxidant and antimicrobial activities of essential oils of Piper caninum Blume. | 2011 | Int J Mol Sci | pmid:22174627 |
Alimi H et al. | Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:22004960 |
Amtul Z et al. | Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids. | 2011 | J. Neurosci. Res. | pmid:21748777 |
Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
Ilić M et al. | Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21757348 |
Espinosa-Neira R et al. | Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. | 2011 | Int. J. Biochem. Cell Biol. | pmid:21945809 |
Mito F et al. | Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. | 2011 | Free Radic. Res. | pmid:21736483 |
Ranchordas MK et al. | A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. | 2011 | Br J Sports Med | pmid:21743106 |
Zened A et al. | Starch and oil in the donor cow diet and starch in substrate differently affect the in vitro ruminal biohydrogenation of linoleic and linolenic acids. | 2011 | J. Dairy Sci. | pmid:22032386 |
Yahya A et al. | Effect of J-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T. | 2011 | J Magn Reson Imaging | pmid:21953706 |
Khadake R et al. | Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. | 2011 | J. Sci. Food Agric. | pmid:21769878 |
Cai W et al. | 3,4,4'-Trihydroxy-trans-stilbene, an analogue of resveratrol, is a potent antioxidant and cytotoxic agent. | 2011 | Free Radic. Res. | pmid:21974738 |
Gibson R and Makrides M | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22019216 |
Beker BY et al. | Antioxidant protective effect of flavonoids on linoleic acid peroxidation induced by copper(II)/ascorbic acid system. | 2011 | Chem. Phys. Lipids | pmid:21925488 |
Zhou XR et al. | Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions. | 2011 | J. Biol. Chem. | pmid:22041902 |
Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
Yang Y et al. | Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. | 2011 | Free Radic. Res. | pmid:21128731 |
Blaul B and Ruther J | How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. | 2011 | Proc. Biol. Sci. | pmid:21429922 |
Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
Mihaljević B et al. | Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. | 2011 | Org. Biomol. Chem. | pmid:21442126 |
Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
Conforti F et al. | Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). | 2011 | Chem. Biodivers. | pmid:21404435 |
Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
Zoia L et al. | Understanding the radical mechanism of lipoxygenases using 31P NMR spin trapping. | 2011 | Bioorg. Med. Chem. | pmid:21474321 |
Martins SV et al. | Dietary conjugated linoleic acid isomers change the unsaturation degree of hepatic fatty acids in neutral lipids but not in polar lipids. | 2011 | Nutr Res | pmid:21481719 |
Negrini R and Mezzenga R | pH-responsive lyotropic liquid crystals for controlled drug delivery. | 2011 | Langmuir | pmid:21452814 |
Ferreira TC et al. | Cell density-dependent linoleic acid toxicity to Saccharomyces cerevisiae. | 2011 | FEMS Yeast Res. | pmid:21457450 |
Sala-Vila A et al. | Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia. | 2011 | Clin Nutr | pmid:21458117 |
Ueda Y et al. | Effect of dietary lipids on longevity and memory in the SAMP8 mice. | 2011 | J. Nutr. Sci. Vitaminol. | pmid:21512289 |
Pi F et al. | Solid-state low temperature→middle temperature phase transition of linoleic acid studied by FTIR spectroscopy. | 2011 | J Phys Chem B | pmid:21520953 |
Atri MS et al. | Structure and stability analysis of cytotoxic complex of camel α-lactalbumin and unsaturated fatty acids produced at high temperature. | 2011 | J. Biomol. Struct. Dyn. | pmid:21469752 |
Carrillo C et al. | Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. | 2011 | Cell. Physiol. Biochem. | pmid:21471726 |
Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
Figueras M et al. | Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. | 2011 | Obesity (Silver Spring) | pmid:20885391 |
Das R et al. | Synthesis of linoleic acid capped copper nanoparticles and their fluorescence study. | 2011 | J Fluoresc | pmid:21221748 |
Lin X et al. | Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs. | 2011 | J. Nutr. Biochem. | pmid:21216581 |
Tuo Y et al. | Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. | 2011 | Endocrine | pmid:21161439 |
Hamberg M | Stereochemistry of hydrogen removal during oxygenation of linoleic acid by singlet oxygen and synthesis of 11(S)-deuterium-labeled linoleic acid. | 2011 | Lipids | pmid:21161604 |