Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Matravadia S et al. | LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition. | 2016 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:26764053 |
Sclafani A et al. | CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17804586 |
Stratford JM et al. | Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18635450 |
Cox JE et al. | Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10712279 |
Dailey MJ et al. | Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24452547 |
Zhou Y et al. | UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. | 2017 | Am. J. Physiol. Renal Physiol. | pmid:28424210 |
Collett ED et al. | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287318 |
Houston M et al. | Oxidized linoleic acid regulates expression and shedding of syndecan-4. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15469957 |
Suh HN et al. | Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18842827 |
Shah BP et al. | TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. | 2012 | Am. J. Physiol., Cell Physiol. | pmid:21998136 |
González-AbuÃn N et al. | Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24371039 |
McKay MC and Worley JF | Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11546665 |
Reiner WB et al. | Fatty acids in mountain gorilla diets: implications for primate nutrition and health. | 2014 | Am. J. Primatol. | pmid:24243235 |
Kawada H et al. | Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2363935 |
Hill EM et al. | Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9569236 |
Cavicchioli P et al. | Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208626 |
Graczyk TK and Shiff CJ | Recovery of avian schistosome cercariae from water using penetration stimulant matrix with an unsaturated fatty acid. | 2000 Sep-Oct | Am. J. Trop. Med. Hyg. | pmid:11388510 |
Mpagi JL et al. | Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides. | 2000 | Am. J. Trop. Med. Hyg. | pmid:11304059 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Shen Q et al. | Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. | 2010 | Anaerobe | pmid:20601030 |
Wang YL et al. | LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. | 2005 | Anal Bioanal Chem | pmid:16132135 |
Ito J et al. | A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. | 2016 | Anal Bioanal Chem | pmid:27549797 |
Tao X et al. | GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. | 2008 | Anal Bioanal Chem | pmid:18622754 |
Billault I et al. | Probing substrate-product relationships by natural abundance deuterium 2D NMR spectroscopy in liquid-crystalline solvents: epoxidation of linoleate to vernoleate by two different plant enzymes. | 2012 | Anal Bioanal Chem | pmid:22349323 |
Wejnerowska G et al. | Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. | 2008 | Anal Sci | pmid:18544865 |
Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
KOKATNUR MG et al. | A RAPID METHOD FOR THE PREPARATION OF PEROXIDES FROM AUTOXIDIZED METHYL ESTERS OF FATTY ACIDS. | 1965 | Anal. Biochem. | pmid:14340025 |
López-Nicolás JM et al. | An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. | 1994 | Anal. Biochem. | pmid:7810887 |
Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
Kotani A et al. | Determination of plasma free fatty acids by high-performance liquid chromatography with electrochemical detection. | 2000 | Anal. Biochem. | pmid:10933857 |
Liu X et al. | Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. | 2013 | Anal. Biochem. | pmid:23850559 |
KOEHLER WR et al. | A METHOD FOR SEPARATING SATURATED FATTY ACID ESTERS FROM UNSATURATED ESTERS FOR GAS CHROMATOGRAPHIC ANALYSIS. | 1964 | Anal. Biochem. | pmid:14213999 |
Pourplanche C et al. | Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. | 1991 | Anal. Biochem. | pmid:1789419 |
Andre JC and Funk MO | Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. | 1986 | Anal. Biochem. | pmid:3101541 |
Oliw EH et al. | Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. | 2006 | Anal. Biochem. | pmid:16712763 |
Cho H et al. | Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. | 2003 | Anal. Biochem. | pmid:12782030 |
Auerbach BJ et al. | A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. | 1992 | Anal. Biochem. | pmid:1632527 |
PINTER KG et al. | QUANTITATIVE DETERMINATION OF SERUM TRIGLYCERIDES BY GLASS-FIBER PAPER CHROMATOGRAPHY. | 1964 | Anal. Biochem. | pmid:14186669 |
Waddington E et al. | Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. | 2001 | Anal. Biochem. | pmid:11355856 |
Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
Zeng YX et al. | Comparative analysis of volatile components from Clematis species growing in China. | 2007 | Anal. Chim. Acta | pmid:17606017 |
P Wrobel T et al. | Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. | 2011 | Analyst | pmid:22007352 |
Tavilani H et al. | Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. | 2006 | Andrologia | pmid:16961570 |
Kreich M and Claus P | Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. | 2005 | Angew. Chem. Int. Ed. Engl. | pmid:16315163 |
O'Quinn PR et al. | Conjugated linoleic acid. | 2000 | Anim Health Res Rev | pmid:11706843 |
McNamara S et al. | Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. | 2003 | Anim. Reprod. Sci. | pmid:12853178 |
Kawahara S et al. | Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. | 2009 | Anim. Sci. J. | pmid:20163609 |
Shibata H et al. | Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. | 2011 | Anim. Sci. J. | pmid:21794014 |
Guo J et al. | Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. | 2013 | Animal | pmid:23031491 |
Men XM et al. | Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. | 2013 | Animal | pmid:23764195 |
Smink W et al. | Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. | 2012 | Animal | pmid:22436184 |
Zened A et al. | In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. | 2012 | Animal | pmid:22436225 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Ranganath LR et al. | Increased mean platelet volume after oestrogen replacement therapy. | 1996 | Ann. Clin. Biochem. | pmid:8937589 |
Taylor AJ | Erythrocyte membrane fatty acid composition in hypercholesterolaemia. | 1994 | Ann. Clin. Biochem. | pmid:7979101 |
Fairfield K | ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. | 2013 | Ann. Intern. Med. | pmid:23689785 |
Davis PA et al. | A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. | 1993 | Ann. Intern. Med. | pmid:8363165 |
Kankaanpää P et al. | Dietary fatty acids and allergy. | 1999 | Ann. Med. | pmid:10480759 |
Chopra M et al. | Free radical scavenging of lutein in vitro. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8129303 |
Thompson RL et al. | Cigarette smoking, polyunsaturated fats, and coronary heart disease. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8512244 |
Sugano M and Koba K | Dietary protein and lipid metabolism: a multifunctional effect. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8489133 |
Merendino N et al. | Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. | 2003 | Ann. N. Y. Acad. Sci. | pmid:15033753 |
Schlame M et al. | Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. | 2002 | Ann. Neurol. | pmid:12112112 |
Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
Charnock JS et al. | Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. | 1985 | Ann. Nutr. Metab. | pmid:3922279 |
Babin F et al. | Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. | 1988 | Ann. Nutr. Metab. | pmid:3195990 |
Carreau JP et al. | Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. | 1982 | Ann. Nutr. Metab. | pmid:6814348 |
Romijn D et al. | A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. | 1998 | Ann. Nutr. Metab. | pmid:9745111 |
Choi YS and Sugano M | Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. | 1988 | Ann. Nutr. Metab. | pmid:2903713 |
Mogenson GJ and Box BM | Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. | 1982 | Ann. Nutr. Metab. | pmid:7137945 |
Adam O et al. | Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. | 1982 | Ann. Nutr. Metab. | pmid:7137955 |
Fuhrmann H and Sallmann HP | Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:8585700 |
Saito M and Yamaguchi M | Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. | 1994 | Ann. Nutr. Metab. | pmid:7832581 |
SaÃn J et al. | Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. | 2013 | Ann. Nutr. Metab. | pmid:23594856 |
Boissonneault GA et al. | Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:7872651 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
Kort WJ et al. | Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. | 1986 | Ann. Nutr. Metab. | pmid:3963748 |
Roshanai F and Sanders TA | Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4037727 |
Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
Charnock JS et al. | Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4051450 |
Adam O | Linoleic acid - the fall of an angel? | 1999 | Ann. Nutr. Metab. | pmid:10725772 |
Charnock JS et al. | Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. | 1985 | Ann. Nutr. Metab. | pmid:4051452 |
Soltysova T and Bellisle F | Nutrition in ten-year-old children of the Liberec area (Czech Republic). | 1994 | Ann. Nutr. Metab. | pmid:7979168 |
Pascaud M and Strouve-Vallet C | Desaturation of 14C linoleic acid by the rat fetus. | 1985 | Ann. Nutr. Metab. | pmid:2983600 |
Roth HP and Kirchgessner M | [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. | 1992 | Ann. Nutr. Metab. | pmid:1354951 |
Aziz AA et al. | Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. | 2010 | Ann. Nutr. Metab. | pmid:20714137 |
Jensen MM et al. | Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. | 1994 | Ann. Nutr. Metab. | pmid:8067685 |
Heine RJ et al. | The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. | 1984 | Ann. Nutr. Metab. | pmid:6476785 |
de Deckere EA et al. | Hepatic de novo fatty acid synthesis in the rat. | 1993 | Ann. Nutr. Metab. | pmid:8215236 |
Katan MB et al. | Biological markers of dietary intake, with emphasis on fatty acids. | 1991 | Ann. Nutr. Metab. | pmid:1776820 |
Xiang M et al. | Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. | 2006 | Ann. Nutr. Metab. | pmid:16988497 |
Decsi T and Koletzko B | Do trans fatty acids impair linoleic acid metabolism in children? | 1995 | Ann. Nutr. Metab. | pmid:7872654 |
De Vriese SR et al. | Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. | 2001 | Ann. Nutr. Metab. | pmid:11786650 |
Black JM and Kinsella JE | Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. | 1993 | Ann. Nutr. Metab. | pmid:8373135 |
Adam O et al. | Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. | 2003 | Ann. Nutr. Metab. | pmid:12624485 |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
Jakobsen K et al. | Heat production and quantitative oxidation of nutrients by physical activity in pigs. | 1994 | Ann. Nutr. Metab. | pmid:8185282 |