Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lasa A et al. | The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. | 2011 Sep-Oct | Nutr Hosp | pmid:22072344 |
| Okui T et al. | Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21723718 |
| Ramandi NF et al. | Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. | 2011 Nov-Dec | J. Food Sci. | pmid:22416687 |
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| Olszewska MA | In vitro antioxidant activity and total phenolic content of the inflorescences, leaves and fruits of Sorbus torminalis (L.) Crantz. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125961 |
| Kezutyte T et al. | Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125963 |
| China R et al. | In vitro antioxidant activity of different cultivars of banana flower (Musa paradicicus L.) extracts available in India. | 2011 Nov-Dec | J. Food Sci. | pmid:22416691 |
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| Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
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| Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
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| Arawwawala M et al. | In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. | 2011 | Acta. Biol. Hung. | pmid:21840826 |
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| Aktumsek A et al. | Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L. species from Turkey flora. | 2011 | Food Chem. Toxicol. | pmid:21878362 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Dailey MJ et al. | Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21917638 |
| Cheng TM et al. | Haemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids. | 2011 | Free Radic. Res. | pmid:21034361 |
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| Lam WM et al. | In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. | 2011 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:21053263 |
| Pink RC et al. | Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism. | 2011 | Nutr Cancer | pmid:21667399 |
| Morganti P et al. | Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial. | 2011 | Int J Cosmet Sci | pmid:21668835 |
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| Lautenslager GT et al. | Effects of nonenzymatic glycation and fatty acids on functional properties of human albumin. | 2011 | Metab. Clin. Exp. | pmid:21632076 |
| Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
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| Aewsiri T et al. | Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. | 2011 | Int. J. Biol. Macromol. | pmid:21334373 |
| You Q et al. | Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. | 2011 | Bioprocess Biosyst Eng | pmid:21340675 |
| Serratosa MP et al. | Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. | 2011 | J. Agric. Food Chem. | pmid:21319807 |
| Zouboulis CC et al. | Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. | 2011 | Br. J. Dermatol. | pmid:21457203 |
| Alloatti A and Uttaro AD | Highly specific methyl-end fatty-acid desaturases of trypanosomatids. | 2011 | Mol. Biochem. Parasitol. | pmid:20974196 |
| Perona JS et al. | Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. | 2011 | Metab. Clin. Exp. | pmid:20934731 |
| Pan Z et al. | Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21295151 |
| Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |
| Rosberg-Cody E et al. | Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. | 2011 | Microbiology (Reading, Engl.) | pmid:21178166 |