Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Alopecia D000505 14 associated lipids
Liver Diseases D008107 31 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Weight Loss D015431 56 associated lipids
Anorexia D000855 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Hyperpigmentation D017495 11 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Helicobacter Infections D016481 21 associated lipids
Melanosis D008548 4 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Coronary Restenosis D023903 10 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Circoviridae Infections D018173 2 associated lipids
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Lactose Intolerance D007787 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Hamazaki T et al. Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. 1989 Prostaglandins pmid:2503856
Beavers WN et al. ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. 2014 J. Am. Chem. Soc. pmid:25034362
Chapkin RS et al. Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. 1989 Cancer Res. pmid:2503244
Chen Q et al. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. 1989 Biochim. Biophys. Acta pmid:2503032
Shimamoto C et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. 2014 Hum. Mol. Genet. pmid:25027319
Arcan I and YemenicioÄŸlu A Controlled release properties of zein-fatty acid blend films for multiple bioactive compounds. 2014 J. Agric. Food Chem. pmid:25025594
pmid:25017702
Hellstrand S et al. Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. 2014 J. Nutr. pmid:25008580
Hamazaki S et al. Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. 1989 Arch. Biochem. Biophys. pmid:2500058
pmid:24996671
pmid:24996268
Hester AG et al. Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. 2014 J. Biol. Chem. pmid:24962583
Kaduce TL et al. Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. 1989 J. Biol. Chem. pmid:2496121
Yavin E et al. Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. 2014 Biochim. Biophys. Acta pmid:24960100
pmid:24954845
Evans SJ et al. Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. 2014 J Psychiatr Res pmid:24953860
Moate PJ et al. Grape marc reduces methane emissions when fed to dairy cows. 2014 J. Dairy Sci. pmid:24952778
Byczkowski JZ and Kulkarni AP Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. 1989 Biochem. Biophys. Res. Commun. pmid:2494999
Anderson GJ and Connor WE On the demonstration of omega-3 essential-fatty-acid deficiency in humans. 1989 Am. J. Clin. Nutr. pmid:2494878
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Stammers JP et al. High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets. 1989 Br. J. Nutr. pmid:2493804
pmid:24931525
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Verlotta A and Trono D Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli. 2014 Protein Expr. Purif. pmid:24925645
Mesti T et al. Metabolic impact of anti-angiogenic agents on U87 glioma cells. 2014 PLoS ONE pmid:24922514
Grossi IM et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. 1989 Cancer Res. pmid:2492204
Hicks M et al. Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation. 1989 Arch. Biochem. Biophys. pmid:2492180
Herchi W et al. Flaxseed hull: Chemical composition and antioxidant activity during development. 2014 J Oleo Sci pmid:24919478
Usami A et al. Characteristic odorants from bailingu oyster mushroom (Pleurotus eryngii var. tuoliensis) and summer oyster mushroom (Pleurotus cystidiosus). 2014 J Oleo Sci pmid:24919476
Bagai S et al. Lipid-modified polyethylenimine-mediated DNA attraction evaluated by molecular dynamics simulations. 2014 J Phys Chem B pmid:24918771
pmid:24911614
pmid:24905048
Woyda-Ploszczyca AM and Jarmuszkiewicz W Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. 2014 PLoS ONE pmid:24904988
Maruyama H et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. 2014 Lipids Health Dis pmid:24885871
Nosaka S and Miyazawa M Characterization of volatile components and odor-active compounds in the oil of edible mushroom Boletopsis leucomelas. 2014 J Oleo Sci pmid:24881770
pmid:24874439
Choi JI et al. Development of microalga Scenedesmus dimorphus mutant with higher lipid content by radiation breeding. 2014 Bioprocess Biosyst Eng pmid:24871276
pmid:24867679
Wennman A et al. Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. 2014 Arch. Biochem. Biophys. pmid:24857825
Chilton FH et al. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. 2014 Nutrients pmid:24853887
Saito H and Ishikawa S Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. 2014 J Oleo Sci pmid:24829130
pmid:24818887
pmid:24816719
pmid:24815769
pmid:24813273
pmid:24796987
pmid:24788685
pmid:24786483
Yang Y et al. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. 2014 Lipids pmid:24777581
pmid:24767084
Darling RA et al. Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760994
pmid:24754783
pmid:24750748
Yang B et al. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. 2014 J. Appl. Microbiol. pmid:24750362
pmid:24748509
pmid:24746836
pmid:24743744
Kurganov BI et al. Kinetics of soybean lipoxygenase reaction in hydrated reversed micelles. 1989 Biochimie pmid:2474334
Mouokeu RS et al. Antifungal and antioxidant activity of Crassocephalum bauchiense (Hutch.) Milne-Redh ethyl acetate extract and fractions (Asteraceae). 2014 BMC Res Notes pmid:24742210
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Madison KC et al. Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. 1989 J. Invest. Dermatol. pmid:2473131
pmid:24727173
Buehlmann C et al. Desert ants locate food by combining high sensitivity to food odors with extensive crosswind runs. 2014 Curr. Biol. pmid:24726153
Song E et al. Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice. 2014 J Am Heart Assoc pmid:24721803
pmid:24717118
pmid:24705332
pmid:24695832
Armstrong EH et al. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. 2014 J. Biol. Chem. pmid:24692551
Buček A et al. Δ12-Fatty acid desaturase from Candida parapsilosis is a multifunctional desaturase producing a range of polyunsaturated and hydroxylated fatty acids. 2014 PLoS ONE pmid:24681902
pmid:24681027
Negrini R et al. Influence of electrostatic interactions on the release of charged molecules from lipid cubic phases. 2014 Langmuir pmid:24673189
pmid:24670121
pmid:24667076
pmid:24666298
Nehdi IA et al. Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product. 2014 J. Food Sci. pmid:24666023
Reed S et al. Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). 2014 Nutrients pmid:24658588
Wu MH et al. A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. 2014 Sci Rep pmid:24651079
Santos S et al. Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. 2014 Eur J Clin Nutr pmid:24642786
pmid:24642113
Nardi F et al. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. 2014 PLoS ONE pmid:24632852
Su MH et al. Chemical composition of seed oils in native Taiwanese Camellia species. 2014 Food Chem pmid:24629982
Rodriguez MA et al. Concordance analysis between estimation methods of milk fatty acid content. 2014 Food Chem pmid:24629954
pmid:24611378
Hashimoto A et al. Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. 1988 Prostaglandins pmid:2459732
Spartano NL et al. Linoleic acid suppresses cholesterol efflux and ATP-binding cassette transporters in murine bone marrow-derived macrophages. 2014 Lipids pmid:24595513
Hall TD et al. Changes during leaf expansion of ΦPSII temperature optima in Gossypium hirsutum are associated with the degree of fatty acid lipid saturation. 2014 J. Plant Physiol. pmid:24594393
Salafsky B et al. Schistosoma mansoni: analysis of cercarial transformation methods. 1988 Exp. Parasitol. pmid:2458958
pmid:24582933
Bazongo P et al. Characteristics, composition and oxidative stability of Lannea microcarpa seed and seed oil. 2014 Molecules pmid:24566330
Ambrozova JV et al. Influence of extractive solvents on lipid and fatty acids content of edible freshwater algal and seaweed products, the green Microalga Chlorella kessleri and the Cyanobacterium Spirulina platensis. 2014 Molecules pmid:24566307
Scalerandi MV et al. Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice. 2014 Nutr Hosp pmid:24559004
pmid:24552275
Youn K et al. Oleic acid and linoleic acid from Tenebrio molitor larvae inhibit BACE1 activity in vitro: molecular docking studies. 2014 J Med Food pmid:24548007
Wooten MW and Wrenn RW Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. 1988 Biochem. Biophys. Res. Commun. pmid:2454109
pmid:24534166
Venkatraman JT and Clandinin MT Ribonucleic acid efflux from isolated mouse liver nuclei is altered by diet and genotypically determined change in nuclear envelope composition. 1988 Biochim. Biophys. Acta pmid:2452656
pmid:24522837
Chevrot M et al. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. 2014 Am. J. Clin. Nutr. pmid:24522446
Paulsen SJ et al. Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. 2014 PLoS ONE pmid:24520357
López A et al. Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model. 2014 J Mech Behav Biomed Mater pmid:24508711