Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Applegate TJ and Sell JL | Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. | 1996 | Poult. Sci. | pmid:8966177 |
Parmentier HK et al. | Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. | 1997 | Poult. Sci. | pmid:9251147 |
Sirri F et al. | Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. | 2003 | Poult. Sci. | pmid:12943310 |
Badinga L et al. | Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. | 2003 | Poult. Sci. | pmid:12580252 |
Engberg RM et al. | Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. | 1996 | Poult. Sci. | pmid:8829233 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Ain Baziz H et al. | Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. | 1996 | Poult. Sci. | pmid:8786940 |
Wang YW et al. | Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. | 2004 | Poult. Sci. | pmid:15615018 |
Du M and Ahn DU | Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. | 2002 | Poult. Sci. | pmid:11902422 |
Vilchez C et al. | Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. | 1991 | Poult. Sci. | pmid:1784570 |
Du M et al. | Quality characteristics of irradiated ready-to-eat breast rolls from turkeys fed conjugated linoleic acid. | 2002 | Poult. Sci. | pmid:12269620 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
Aletor VA et al. | The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. | 2003 | Poult. Sci. | pmid:12762403 |
Shin D et al. | Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. | 2012 | Poult. Sci. | pmid:22399741 |
Sammon AM | Dietary linoleic acid, immune inhibition and disease. | 1999 | Postgrad Med J | pmid:10448487 |
Adiguzel A et al. | Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria. | 2009 | Pol. J. Microbiol. | pmid:19469289 |
Padayachee T et al. | The Detection of Metabolite-Mediated Gene Module Co-Expression Using Multivariate Linear Models. | 2016 | PLoS ONE | pmid:26918614 |
Phan CW et al. | Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism. | 2015 | PLoS ONE | pmid:26565787 |
Gouveia-Figueira S et al. | Serum levels of oxylipins in achilles tendinopathy: an exploratory study. | 2015 | PLoS ONE | pmid:25875933 |
Chen S et al. | Profiling of volatile compounds and associated gene expression and enzyme activity during fruit development in two cucumber cultivars. | 2015 | PLoS ONE | pmid:25799542 |
Manosalva C et al. | Cloning, identification and functional characterization of bovine free fatty acid receptor-1 (FFAR1/GPR40) in neutrophils. | 2015 | PLoS ONE | pmid:25790461 |
Xing J et al. | Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods. | 2015 | PLoS ONE | pmid:25789875 |
Saccenti E et al. | Strategies for individual phenotyping of linoleic and arachidonic acid metabolism using an oral glucose tolerance test. | 2015 | PLoS ONE | pmid:25786212 |
Ciepiela P et al. | Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting. | 2015 | PLoS ONE | pmid:25763593 |
Fukuda S et al. | Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. | 2009 | PLoS ONE | pmid:19287504 |
Mesti T et al. | Metabolic impact of anti-angiogenic agents on U87 glioma cells. | 2014 | PLoS ONE | pmid:24922514 |
Woyda-Ploszczyca AM and Jarmuszkiewicz W | Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. | 2014 | PLoS ONE | pmid:24904988 |
Troche JR et al. | Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers. | 2016 | PLoS ONE | pmid:26967509 |
BuÄek A et al. | Δ12-Fatty acid desaturase from Candida parapsilosis is a multifunctional desaturase producing a range of polyunsaturated and hydroxylated fatty acids. | 2014 | PLoS ONE | pmid:24681902 |
Prasad A and PospÃÅ¡il P | Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. | 2011 | PLoS ONE | pmid:21799835 |
Zhao Y et al. | Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. | 2013 | PLoS ONE | pmid:23565210 |
Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
de Goede J et al. | N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. | 2013 | PLoS ONE | pmid:23741290 |
Noel JT et al. | Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. | 2010 | PLoS ONE | pmid:20824208 |
Vinaixa M et al. | Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. | 2011 | PLoS ONE | pmid:22194988 |
Kenny JG et al. | Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. | 2013 | PLoS ONE | pmid:23861785 |
Benbrook CM et al. | Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. | 2013 | PLoS ONE | pmid:24349282 |
Fatima T et al. | Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. | 2012 | PLoS ONE | pmid:22558083 |
Zhao A et al. | Use of real-time cellular analysis and Plackett-Burman design to develop the serum-free media for PC-3 prostate cancer cells. | 2017 | PLoS ONE | pmid:28945791 |
Sinanoglou VJ et al. | Factors affecting human colostrum fatty acid profile: A case study. | 2017 | PLoS ONE | pmid:28410426 |
Inzaugarat ME et al. | New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans. | 2017 | PLoS ONE | pmid:28257515 |
Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
Sisignano M et al. | Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. | 2013 | PLoS ONE | pmid:24349046 |
Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
Zhang YH et al. | The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life. | 2016 | PLoS ONE | pmid:27780226 |
Rodrigues HG et al. | Oral Administration of Linoleic Acid Induces New Vessel Formation and Improves Skin Wound Healing in Diabetic Rats. | 2016 | PLoS ONE | pmid:27764229 |
Liu G et al. | Biotype Characterization, Developmental Profiling, Insecticide Response and Binding Property of Bemisia tabaci Chemosensory Proteins: Role of CSP in Insect Defense. | 2016 | PLoS ONE | pmid:27167733 |
Jumbe T et al. | Whole Blood Levels of the n-6 Essential Fatty Acid Linoleic Acid Are Inversely Associated with Stunting in 2-to-6 Year Old Tanzanian Children: A Cross-Sectional Study. | 2016 | PLoS ONE | pmid:27137223 |
Nardi F et al. | Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. | 2014 | PLoS ONE | pmid:24632852 |
Abdullah BM et al. | Polyesters Based on Linoleic Acid for Biolubricant Basestocks: Low-Temperature, Tribological and Rheological Properties. | 2016 | PLoS ONE | pmid:27008312 |