Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Lung Neoplasms D008175 171 associated lipids
Inflammation D007249 119 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Heart Failure D006333 36 associated lipids
Coronary Disease D003327 70 associated lipids
Alopecia D000505 14 associated lipids
Liver Diseases D008107 31 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Olfaction Disorders D000857 17 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Seizures D012640 87 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Hypertension, Renal D006977 9 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Aortic Diseases D001018 11 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Atherosclerosis D050197 85 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Insulin Resistance D007333 99 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Weight Loss D015431 56 associated lipids
Anorexia D000855 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Hyperpigmentation D017495 11 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Helicobacter Infections D016481 21 associated lipids
Melanosis D008548 4 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Coronary Restenosis D023903 10 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Circoviridae Infections D018173 2 associated lipids
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Lactose Intolerance D007787 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Rosenthal MD and Whitehurst MC Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. 1983 Biochim. Biophys. Acta pmid:6615875
Düsing R et al. Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. 1983 Am. J. Physiol. pmid:6337507
Yoshida M et al. Linoleate and fatty acid compositions in the serum lipids of Japanese patients with multiple sclerosis. 1983 Acta Neurol. Scand. pmid:6364685
Rustin P et al. Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. 1983 Arch. Biochem. Biophys. pmid:6414377
Campbell TB and Lueking DR Long-chain fatty acid assimilation By rhodopseudomonas sphaeroides. 1983 J. Bacteriol. pmid:6600450
Kirstein D et al. Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. 1983 Br. J. Nutr. pmid:6315055
Sanders TA Dietary fat and platelet function. 1983 Clin. Sci. pmid:6309463
Frankel EN Volatile lipid oxidation products. 1983 Prog. Lipid Res. pmid:6306693
Kreutter D et al. The effect of essential fatty acid deficiency on the stimulation of intestinal calcium transport by 1,25-dihydroxyvitamin D3. 1983 J. Biol. Chem. pmid:6687596
Rapp JH et al. Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression. 1983 J. Lipid Res. pmid:6644183
Gavigan SJ and Knight BL The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. 1983 Biochem. J. pmid:6651782
Hoover RL et al. Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. 1983 J. Cell Biol. pmid:6223042
Greenway DL and Dyke KG The effect of membrane-bound beta-lactamase on linoleic acid sensitivity in Staphylococcus aureus. 1983 J. Gen. Microbiol. pmid:6605415
Breton M et al. Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. 1983 Biochem. Biophys. Res. Commun. pmid:6230079
Shultz TD and Leklem JE Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. 1983 Am. J. Clin. Nutr. pmid:6849273
Arudi RL et al. Purification of oleic acid and linoleic acid. 1983 J. Lipid Res. pmid:6854155
Ookhtens M and Baker N Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. 1983 Am. J. Physiol. pmid:6295191
Kaduce TL et al. Linoleic acid metabolism and prostaglandin production by cultured bovine pulmonary artery endothelial cells. 1982 Sep-Oct Arteriosclerosis pmid:6751307
Tobian L et al. Influence of renal prostaglandins and dietary linoleate on hypertension in Dahl S rats. 1982 May-Jun Hypertension pmid:6950924
Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee. 1982 Mar-Apr Arteriosclerosis pmid:7039581
Goodnight SH et al. Polyunsaturated fatty acids, hyperlipidemia, and thrombosis. 1982 Mar-Apr Arteriosclerosis pmid:7039582
Shechter Y et al. Evaluation of factors responsible for the inability of insulin to antagonize lipolysis due to high concentrations of catecholamines. 1982 Biochem. Biophys. Res. Commun. pmid:6297490
Abbas MK et al. Ultrastructure and fatty acid composition of fatty acid-modified Morris 7777 hepatoma cells. 1982 Cancer Res. pmid:6812950
Hoelgaard A and Møllgaard B Permeation of linoleic acid through skin in vitro. 1982 J. Pharm. Pharmacol. pmid:6127396
Letts V et al. Synthesis and utilization of fatty acids by wild-type and fatty acid auxotrophs of Caulobacter crescentus. 1982 J. Bacteriol. pmid:7107555
Enser M and Roberts JL The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. 1982 Biochem. J. pmid:6128973
Mitranic MM et al. The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. 1982 Biochim. Biophys. Acta pmid:6217837
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Carreau JP et al. Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. 1982 Ann. Nutr. Metab. pmid:6814348
McKerrow JH and Jeong KH Schistosoma mansoni: cercarial degradation of a radioactively labeled collagen gel. 1982 Exp. Parasitol. pmid:7060706
De Schrijver R and Privett OS Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. 1982 J. Nutr. pmid:6279803
O'Connell M et al. The interaction of free fatty acids in radioimmunoassays for reverse triiodothyronine. 1982 J. Clin. Endocrinol. Metab. pmid:7096540
Yoo TJ et al. Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells. 1982 Cancer Res. pmid:7105033
Anderson RL Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. 1982 Am. J. Clin. Nutr. pmid:7081132
Mogenson GJ and Box BM Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. 1982 Ann. Nutr. Metab. pmid:7137945
Adam O et al. Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. 1982 Ann. Nutr. Metab. pmid:7137955
Rosenblum WI Unsaturated fatty acids and cyclooxygenase inhibitors: effects on pial arterioles. 1982 Am. J. Physiol. pmid:6801999
Cuebas D and Schulz H Evidence for a modified pathway of linoleate degradation. Metabolism of 2,4-decadienoyl coenzyme A. 1982 J. Biol. Chem. pmid:7142199
Iritani N and Ikeda Y Activation of catalase and other enzymes by corn oil intake. 1982 J. Nutr. pmid:7143106
Kaya K and Miura T Effects of nitrogen dioxide on fatty acid compositions of red cell membranes, sera, and livers in rats. 1982 Environ. Res. pmid:6802637
Shimp JL et al. The effects of dietary trilinoelaidin on fatty acid and acyl desaturases in rat liver. 1982 J. Nutr. pmid:6802940
Needleman SW et al. Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. 1982 Prostaglandins pmid:6819602
Rosing U et al. Relative fatty acid composition of serum lecithin in the second half of the normal pregnancy. 1982 Gynecol. Obstet. Invest. pmid:7129232
Beaudry GA et al. Stimulation of deacylation in Madin-Darby canine kidney cells. Specificity of deacylation and prostaglandin production in 12-O-tetradecanoylphorbol-13-acetate-treated cells. 1982 J. Biol. Chem. pmid:6809762
Claeys M et al. Characterization of monohydroxylated lipoxygenase metabolites of arachidonic and linoleic acid in rabbit peritoneal tissue. 1982 Biochim. Biophys. Acta pmid:6814493
Simpson HC and Mann JI Does low dietary intake of linoleic acid predispose to myocardial infarction? 1982 Br Med J (Clin Res Ed) pmid:6814662
Hill EG et al. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6951178
Seward RA et al. Effects of potassium sorbate and other antibotulinal agents on germination and outgrowth of Clostridium botulinum type E spores in microcultures. 1982 Appl. Environ. Microbiol. pmid:6758699
Rosenthal MD and Whitehurst MC Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. 1982 J. Cell. Physiol. pmid:6294123
Christophersen BO et al. Studies on the regulation of arachidonic acid synthesis in isolated rat liver cells. 1982 Biochim. Biophys. Acta pmid:6812639