Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brynes AE et al. | Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. | 2000 | Am. J. Clin. Nutr. | pmid:11063437 |
| Hennig B et al. | Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. | 1996 | Am. J. Clin. Nutr. | pmid:8602587 |
| Routi T et al. | Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. | 1996 | Am. J. Clin. Nutr. | pmid:8602597 |
| Louheranta AM et al. | Linoleic acid intake and susceptibility of very-low-density and low density lipoproteins to oxidation in men. | 1996 | Am. J. Clin. Nutr. | pmid:8615351 |
| van Egmond AW et al. | Effect of linoleic acid intake on growth of infants with cystic fibrosis. | 1996 | Am. J. Clin. Nutr. | pmid:8615359 |
| Anderson RL | Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. | 1982 | Am. J. Clin. Nutr. | pmid:7081132 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
| Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
| Villalpando S et al. | [13C]linoleic acid oxidation and transfer into milk in stunted lactating women with contrasting body mass indexes. | 2001 | Am. J. Clin. Nutr. | pmid:11729835 |
| Anderson GJ and Connor WE | On the demonstration of omega-3 essential-fatty-acid deficiency in humans. | 1989 | Am. J. Clin. Nutr. | pmid:2494878 |
| Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
| Jeppesen PB et al. | Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. | 1999 | Am. J. Clin. Nutr. | pmid:10393142 |
| Jannace PW et al. | Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. | 1992 | Am. J. Clin. Nutr. | pmid:1323926 |
| Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
| Bradbury KE et al. | The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. | 2010 | Am. J. Clin. Nutr. | pmid:19955401 |
| Hrboticky N et al. | Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. | 1991 | Am. J. Clin. Nutr. | pmid:1989416 |
| Erickson KL | Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? | 1998 | Am. J. Clin. Nutr. | pmid:9665090 |
| Zock PL and Katan MB | Linoleic acid intake and cancer risk: a review and meta-analysis. | 1998 | Am. J. Clin. Nutr. | pmid:9665108 |
| MACDONALD I and BARRY PJ | CHANGES IN THE FATTY ACID PATTERN OF THE ADIPOSE TISSUE OF OBESE SUBJECTS WHILE ON A REDUCING REGIMEN. | 1964 | Am. J. Clin. Nutr. | pmid:14212750 |
| Cleland LG et al. | Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. | 1992 | Am. J. Clin. Nutr. | pmid:1310374 |
| Herbel BK et al. | Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9459383 |
| Meerarani P et al. | Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. | 2000 | Am. J. Clin. Nutr. | pmid:10617950 |
| Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
| Voorrips LE et al. | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. | 2002 | Am. J. Clin. Nutr. | pmid:12324303 |
| Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
| Jiang J et al. | Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. | 1999 | Am. J. Clin. Nutr. | pmid:10393134 |
| James MJ et al. | Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8379505 |
| Cosgrove MC et al. | Dietary nutrient intakes and skin-aging appearance among middle-aged American women. | 2007 | Am. J. Clin. Nutr. | pmid:17921406 |
| Iacono JM and Dougherty RM | Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. | 1991 | Am. J. Clin. Nutr. | pmid:1900384 |
| Thijssen MA and Mensink RP | Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. | 2005 | Am. J. Clin. Nutr. | pmid:16155261 |
| Baylin A et al. | alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. | 2007 | Am. J. Clin. Nutr. | pmid:17284757 |
| Asciutti-Moura LS et al. | Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. | 1988 | Am. J. Clin. Nutr. | pmid:3421207 |
| Feunekes GI et al. | Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. | 1993 | Am. J. Clin. Nutr. | pmid:8379504 |
| Cunnane SC | Diodoquin and linoleic acid absorption in zinc deficiency. | 1981 | Am. J. Clin. Nutr. | pmid:6792900 |
| Djoussé L et al. | Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. | 2001 | Am. J. Clin. Nutr. | pmid:11684529 |
| Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |
| Goyens PL et al. | Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. | 2006 | Am. J. Clin. Nutr. | pmid:16825680 |
| Abbey M et al. | Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8438773 |
| McMurchie EJ et al. | Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. | 1984 | Am. J. Clin. Nutr. | pmid:6720626 |
| Oosthuizen W et al. | Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study. | 2006 | Am. J. Clin. Nutr. | pmid:16685065 |
| Shultz TD and Leklem JE | Selenium status of vegeterians, nonvegetarians, and hormone-dependent cancer subjects. | 1983 | Am. J. Clin. Nutr. | pmid:6849273 |
| Cunnane SC et al. | Beta-oxidation of linoleate in obese men undergoing weight loss. | 2001 | Am. J. Clin. Nutr. | pmid:11273844 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Freeman VL et al. | Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? | 2001 | Am. J. Clin. Nutr. | pmid:11273858 |
| Merchant AT et al. | Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. | 2005 | Am. J. Clin. Nutr. | pmid:16155282 |
| Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
| Chan JK et al. | Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. | 1991 | Am. J. Clin. Nutr. | pmid:1673589 |
| Arca M et al. | Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. | 1987 | Am. J. Clin. Nutr. | pmid:3604961 |