Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
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Decsi T and Koletzko B | Do trans fatty acids impair linoleic acid metabolism in children? | 1995 | Ann. Nutr. Metab. | pmid:7872654 |
Boissonneault GA et al. | Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:7872651 |
Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
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Bulan EJ et al. | Immature maxi-K channels exhibit heterogeneous properties in the embryonic rat telencephalon. | 1994 | Dev. Neurosci. | pmid:7867514 |
Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
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Croft KD et al. | Oxidation of low-density lipoproteins: effect of antioxidant content, fatty acid composition and intrinsic phospholipase activity on susceptibility to metal ion-induced oxidation. | 1995 | Biochim. Biophys. Acta | pmid:7857965 |
Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
Kvilekval K et al. | Fatty acids as determinants of triglyceride and cholesteryl ester synthesis by isolated hepatocytes: kinetics as a function of various fatty acids. | 1994 | J. Lipid Res. | pmid:7852855 |
Fuhrman B et al. | Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. | 1994 | Atherosclerosis | pmid:7840815 |
Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Roberts TL et al. | trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. | 1995 | Lancet | pmid:7837861 |
Saito M and Yamaguchi M | Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. | 1994 | Ann. Nutr. Metab. | pmid:7832581 |
Thompson L et al. | Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration. | 1994 | Gut | pmid:7828972 |
Nada MA et al. | Evidence for intermediate channeling in mitochondrial beta-oxidation. | 1995 | J. Biol. Chem. | pmid:7822275 |
Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
Jones RE | A hypothesis for early intervention in SIDS. | 1994 | Clin Pediatr (Phila) | pmid:7813148 |
López-Nicolás JM et al. | An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. | 1994 | Anal. Biochem. | pmid:7810887 |
Livrea MA and Tesoriere L | Lipoperoxyl radical-scavenging activity of vitamin A and analogs in homogeneous solution. | 1994 | Meth. Enzymol. | pmid:7808312 |
Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
Schmitt A et al. | Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. | 1995 | Biochim. Biophys. Acta | pmid:7786889 |
Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
Jones RE | A common factor for cardiac or respiratory failure in SIDS. | 1995 | Clin Pediatr (Phila) | pmid:7774147 |
Santanam N and Parthasarathy S | Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. | 1995 | J. Clin. Invest. | pmid:7769102 |
Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
López-Nicolás JM et al. | Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. | 1995 | Biochem. J. | pmid:7755559 |
Welsch CW | Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. | 1995 | Free Radic. Biol. Med. | pmid:7750800 |
Leis HJ et al. | On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. | 1995 | Br. J. Pharmacol. | pmid:7735686 |
Campbell FM et al. | Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733952 |
Angerman-Stewart JA et al. | Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. | 1995 | Arch. Biochem. Biophys. | pmid:7733666 |
Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Umezawa M et al. | Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). | 1995 | Brain Res. | pmid:7712178 |
Jiang WG et al. | Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. | 1995 | Br. J. Cancer | pmid:7710939 |
Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
van Greevenbroek MM et al. | Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. | 1995 | J. Lipid Res. | pmid:7706938 |
Shi X et al. | Silica radical-induced DNA damage and lipid peroxidation. | 1994 | Environ. Health Perspect. | pmid:7705289 |
Sud'ina GF et al. | Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. | 1993 | FEBS Lett. | pmid:7689063 |
Bailey JM et al. | Dietary linoleic acid in alcohol-induced liver cirrhosis. | 1995 | Biochem. Soc. Trans. | pmid:7672270 |