Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Lymphopenia D008231 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Melanosis D008548 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Otitis Externa D010032 8 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Hypertension, Renal D006977 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Aortic Diseases D001018 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Jenkins TC et al. Dietary soybean oil changes lipolytic rate and composition of fatty acids in plasma membranes of ovine adipocytes. 1994 J. Nutr. pmid:8145079
JAGANNATHAN SN Effect of feeding different fat mixtures providing the same amount of linoleic acid, on serum cholesterol levels in monkeys and liver cholesterol concentration in cholesterol-fed rats. 1962 J. Nutr. pmid:14450883
JAGANNATHAN SN Effect of feeding fat blends of hydrogenated groundnut (peanut) fat and cottonseed oil containing different levels of linoleic acid on serum choles terol levels in monkeys (Macaca radiata) and liver cholesterol concentration in cholesterol-fed rats. 1962 J. Nutr. pmid:14450884
Kissil GW et al. Capacity of the European eel (Anguilla anguilla) to elongate and desaturate dietary linoleic acid. 1987 J. Nutr. pmid:3114442
Hennig B et al. Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. 1990 J. Nutr. pmid:2329387
Kinter M et al. Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity. 1996 J. Nutr. pmid:9001361
Buckman DK et al. Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. 1990 J. Nutr. pmid:2313378
Sisk MB et al. Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. 2001 J. Nutr. pmid:11385051
Misikangas M et al. High linoleic acid, low vegetable, and high oleic acid, high vegetable diets affect platelet activation similarly in healthy women and men. 2001 J. Nutr. pmid:11385056
Baumgard LH et al. Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). 2001 J. Nutr. pmid:11385065
Terpstra AH Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. 2001 J. Nutr. pmid:11435531
Cardot P et al. Essential fatty acid deficiency during pregnancy in the rat: influence of dietary carbohydrates. 1987 J. Nutr. pmid:3116179
Cunnane SC and McAdoo KR Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes. 1987 J. Nutr. pmid:3116180
Cleland LG et al. Dietary (n-9) eicosatrienoic acid from a cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid. 1996 J. Nutr. pmid:8648425
Osada K et al. Dietary protein modifies oxidized cholesterol-induced alterations of linoleic acid and cholesterol metabolism in rats. 1996 J. Nutr. pmid:8648438
REID ME et al. NUTRITIONAL STUDIES WITH THE GUINEA PIG. X. DETERMINATION OF THE LINOLEIC ACID REQUIREMENT. 1964 J. Nutr. pmid:14151124
Clouard C et al. Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. 2015 J. Nutr. pmid:25644359
Reinders I et al. Plasma phospholipid PUFAs are associated with greater muscle and knee extension strength but not with changes in muscle parameters in older adults. 2015 J. Nutr. pmid:25355842
Brown JM and McIntosh MK Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. 2003 J. Nutr. pmid:14519781
Peterson DG et al. Diet-induced milk fat depression in dairy cows results in increased trans-10, cis-12 CLA in milk fat and coordinate suppression of mRNA abundance for mammary enzymes involved in milk fat synthesis. 2003 J. Nutr. pmid:14519791
Terpstra AH et al. Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice. 2003 J. Nutr. pmid:14519807
Bassaganya-Riera J et al. Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression. 2003 J. Nutr. pmid:14519812
Cho Y and Ziboh VA Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. 1995 J. Nutr. pmid:7472653
Al MD et al. Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy. 1995 J. Nutr. pmid:7472662
Sher J et al. Dietary conjugated linoleic acid lowers plasma cholesterol during cholesterol supplementation, but accentuates the atherogenic lipid profile during the acute phase response in hamsters. 2003 J. Nutr. pmid:12566483
Chow CK Dietary beta-tocopherol and serum concentrations of sex hormone-binding globulin. 2009 J. Nutr. pmid:19710160
Jones S et al. Isomers of conjugated linoleic acid (CLA) are incorporated into egg yolk lipids by CLA-fed laying hens. 2000 J. Nutr. pmid:10917915
Xu X et al. Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. 2003 J. Nutr. pmid:12612134
Kamlage B et al. Linoleic acid conjugation by human intestinal microorganisms is inhibited by glucose and other substrates in vitro and in gnotobiotic rats. 2000 J. Nutr. pmid:10917922
Yamasaki M et al. Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. 2003 J. Nutr. pmid:12612153
Arab L Biomarkers of fat and fatty acid intake. 2003 J. Nutr. pmid:12612178
Baylin A et al. Serum Trans Fatty Acids Are Not Associated with Weight Gain or Linear Growth in School-Age Children. 2015 J. Nutr. pmid:26180252
Becker W and MÃ¥nsson JE Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. 1985 J. Nutr. pmid:4045568
Hontecillas R et al. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. 2002 J. Nutr. pmid:12097686
Kimura Y Carp oil or oleic acid, but not linoleic acid or linolenic acid, inhibits tumor growth and metastasis in Lewis lung carcinoma-bearing mice. 2002 J. Nutr. pmid:12097695
Lebold KM et al. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 2011 J. Nutr. pmid:22013196
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
WALKER BL and KUMMEROW FA DIETARY FAT AND THE STRUCTURE AND PROPERTIES OF RAT ERYTHROCYTES. III. RESPONSE OF ERYTHROCYTE FATTY ACIDS TO VARIOUS DIETARY FATS. 1964 J. Nutr. pmid:14133362
Eder K and Kirchgessner M Dietary fat influences the effect of zinc deficiency on liver lipids and fatty acids in rats force-fed equal quantities of diet. 1994 J. Nutr. pmid:7931700
Dunbar BL and Bauer JE Conversion of essential fatty acids by Delta 6-desaturase in dog liver microsomes. 2002 J. Nutr. pmid:12042499
Raes K et al. The deposition of conjugated linoleic acids in eggs of laying hens fed diets varying in fat level and fatty acid profile. 2002 J. Nutr. pmid:11823576
WOOD RD et al. Metabolism of labeled linoleic-1-C-14 acid in the sheep rumen. 1963 J. Nutr. pmid:14001756
CASTER WO et al. Determination of linoleate requirement of swine by a new method of estimating nutritional requirement. 1962 J. Nutr. pmid:14019220
Nagao K et al. Dietary conjugated linoleic acid alleviates nonalcoholic fatty liver disease in Zucker (fa/fa) rats. 2005 J. Nutr. pmid:15623825
Becker W Distribution of 14C after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. 1984 J. Nutr. pmid:6470826
Belury MA Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. 2002 J. Nutr. pmid:12368384
Gatlin LA et al. Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. 2002 J. Nutr. pmid:12368402
Hall JA et al. The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. 2006 J. Nutr. pmid:16920851
Kim EJ et al. Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. 2003 J. Nutr. pmid:12888657
Awad AB and Chattopadhyay JP Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes. 1986 J. Nutr. pmid:3723204
WEIGENSBERG BI and MCMILLAN GC SERUM AND AORTIC LIPIDS IN RABBITS FED CHOLESTEROL AND LINOLEIC ACID STEREOISOMERS. 1964 J. Nutr. pmid:14194430
Liou YA et al. Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men. 2007 J. Nutr. pmid:17374659
MacDonald ML et al. Role of linoleate as an essential fatty acid for the cat independent of arachidonate synthesis. 1983 J. Nutr. pmid:6408230
Azain MJ et al. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. 2000 J. Nutr. pmid:10827208
Bell JG et al. High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. 1991 J. Nutr. pmid:1861166
Gupta SV and Khosla P Pork fat and chicken fat similarly affect plasma lipoprotein metabolism in cynomolgus monkeys fed diets with adequate levels of linoleic acid. 2000 J. Nutr. pmid:10801922
RAHM JJ and HOLMAN RT EFFECT OF LINOLEIC ACID UPON THE METABOLISM OF LINOLENIC ACID. 1964 J. Nutr. pmid:14210015
Helge JW et al. Regular exercise modulates muscle membrane phospholipid profile in rats. 1999 J. Nutr. pmid:10460197
Olson RE The key to an enigma: how do dietary polyunsaturated fatty acids lower serum cholesterol? 2002 J. Nutr. pmid:11773520
Mimoun M et al. Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. 2009 J. Nutr. pmid:19828687
Kabagambe EK et al. The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica. 2005 J. Nutr. pmid:16251629
Wickwire MA et al. Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. 1987 J. Nutr. pmid:3470441
LYMAN RL et al. LIVER LIPID ACCUMULATION IN ISOLEUCINE-DEFICIENT RATS. 1964 J. Nutr. pmid:14151129
Schafer E and Arnrich L Effects of dietary vitamin E on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid. 1984 J. Nutr. pmid:6726476
Ritzenthaler KL et al. Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. 2001 J. Nutr. pmid:11340114
Blankson H et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. 2000 J. Nutr. pmid:11110851
Bee G Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. 2000 J. Nutr. pmid:11110857
Takahashi R et al. Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. 1987 J. Nutr. pmid:2888839
WOODALL AN et al. NUTRITION OF SALMONOID FISHES. 13. THE ALPHA-TOCOPHEROL REQUIREMENT OF CHINOOK SALMON. 1964 J. Nutr. pmid:14236910
RAHM JJ and HOLMAN RT STUDIES OF THE METABOLISM OF POLYUNSATURATED ACIDS BY SHORT-TERM EXPERIMENTS. 1964 J. Nutr. pmid:14236913
Le May C et al. Fatty acids induce L-CPT I gene expression through a PPARalpha-independent mechanism in rat hepatoma cells. 2005 J. Nutr. pmid:16177188
Tan B et al. Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. 2011 J. Nutr. Biochem. pmid:20619625
Simón E et al. trans-10,cis-12 conjugated linoleic acid prevents adiposity but not insulin resistance induced by an atherogenic diet in hamsters. 2006 J. Nutr. Biochem. pmid:16111872
Nicolosi RJ et al. Decreased aortic early atherosclerosis and associated risk factors in hypercholesterolemic hamsters fed a high- or mid-oleic acid oil compared to a high-linoleic acid oil. 2004 J. Nutr. Biochem. pmid:15350986
Gorinstein S et al. Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. 2003 J. Nutr. Biochem. pmid:12742543
Zheng Y et al. Role of caveolin-1 in EGCG-mediated protection against linoleic-acid-induced endothelial cell activation. 2009 J. Nutr. Biochem. pmid:18656337
Poudyal H et al. Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23333092
Du C et al. Dietary polyunsaturated fatty acids suppress acute hepatitis, alter gene expression and prolong survival of female Long-Evans Cinnamon rats, a model of Wilson disease. 2004 J. Nutr. Biochem. pmid:15135151
Hennig B et al. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling. 2006 J. Nutr. Biochem. pmid:16563718
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
Javadi M et al. Prolonged feeding of mice with conjugated linoleic acid increases hepatic fatty acid synthesis relative to oxidation. 2004 J. Nutr. Biochem. pmid:15590272
Matesanz N et al. Linoleic acid increases monocyte chemotaxis and adhesion to human aortic endothelial cells through protein kinase C- and cyclooxygenase-2-dependent mechanisms. 2012 J. Nutr. Biochem. pmid:21840193
Tsuzuki T et al. Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. 2006 J. Nutr. Biochem. pmid:16426831
Alvaro A et al. Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids. 2010 J. Nutr. Biochem. pmid:19443194
Walloschke B et al. Enrichment of RAW264.7 macrophages with essential 18-carbon fatty acids affects both respiratory burst and production of immune modulating cytokines. 2010 J. Nutr. Biochem. pmid:19447017
de Batlle J et al. Association between Ω3 and Ω6 fatty acid intakes and serum inflammatory markers in COPD. 2012 J. Nutr. Biochem. pmid:21889886
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Morise A et al. Effects of dietary alpha linolenic acid on cholesterol metabolism in male and female hamsters of the LPN strain. 2004 J. Nutr. Biochem. pmid:14711461
McNeel RL and Mersmann HJ Effects of isomers of conjugated linoleic acid on porcine adipocyte growth and differentiation. 2003 J. Nutr. Biochem. pmid:12832030
Mitmesser SH and Carr TP Trans fatty acids alter the lipid composition and size of apoB-100-containing lipoproteins secreted by HepG2 cells. 2005 J. Nutr. Biochem. pmid:15741053
Sauer LA et al. Dietary factors and growth and metabolism in experimental tumors. 2007 J. Nutr. Biochem. pmid:17418560
Chen JR et al. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. 2004 J. Nutr. Biochem. pmid:15302081
König B and Eder K Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines. 2006 J. Nutr. Biochem. pmid:16216487
Sankaran D et al. COX-2 expression in cystic kidneys is dependent on dietary n-3 fatty acid composition. 2007 J. Nutr. Biochem. pmid:17475460
Lin X et al. Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs. 2011 J. Nutr. Biochem. pmid:21216581
Domenichiello AF et al. The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats. 2016 J. Nutr. Biochem. pmid:27012633
Mochizuki K et al. PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. 2008 J. Nutr. Sci. Vitaminol. pmid:18797151
Ueda Y et al. Effect of dietary lipids on longevity and memory in the SAMP8 mice. 2011 J. Nutr. Sci. Vitaminol. pmid:21512289
Poon JF et al. In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. 2013 J. Org. Chem. pmid:23701313
Lin D et al. Synthesis of six epoxyketooctadecenoic acid (EKODE) isomers, their generation from nonenzymatic oxidation of linoleic acid, and their reactivity with imidazole nucleophiles. 2007 J. Org. Chem. pmid:17979284