Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
Kawahara S et al. | Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. | 2009 | Anim. Sci. J. | pmid:20163609 |
Calder PC | Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? | 2009 | Br. J. Nutr. | pmid:19166631 |
Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
Uygun DA et al. | A novel support for antibody purification: fatty acid attached chitosan beads. | 2009 | Colloids Surf B Biointerfaces | pmid:19196498 |
Carlotti ME et al. | Role of particle coating in controlling skin damage photoinduced by titania nanoparticles. | 2009 | Free Radic. Res. | pmid:19199115 |
Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
MartÃnez-Force E et al. | Influence of specific fatty acids on the asymmetric distribution of saturated fatty acids in sunflower (Helianthus annuus L.) triacylglycerols. | 2009 | J. Agric. Food Chem. | pmid:19166295 |
Zhao Z et al. | Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. | 2009 | Biomacromolecules | pmid:19175304 |
Eriksson S et al. | Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. | 2009 | Br. J. Nutr. | pmid:19175947 |
Gülçin I | Antioxidant activity of L-adrenaline: a structure-activity insight. | 2009 | Chem. Biol. Interact. | pmid:18929549 |
de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
Lapenna D et al. | Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. | 2009 | Biochim. Biophys. Acta | pmid:18950686 |
Garscha U and Oliw EH | Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity. | 2009 | J. Biol. Chem. | pmid:19289462 |
Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
Nayeem F et al. | Dietary beta-tocopherol and linoleic acid, serum insulin, and waist circumference predict circulating sex hormone-binding globulin in premenopausal women. | 2009 | J. Nutr. | pmid:19339706 |
Fukuda S et al. | Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. | 2009 | PLoS ONE | pmid:19287504 |
Choi NJ et al. | Characterizations of environmental factors in conjugated linoleic acid production by mixed rumen bacteria. | 2009 | J. Agric. Food Chem. | pmid:19754193 |
Roche M et al. | Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. | 2009 | Biochim. Biophys. Acta | pmid:19714864 |
Pianaro A et al. | Stingless bees: chemical differences and potential functions in Nannotrigona testaceicornis and Plebeia droryana males and workers. | 2009 | J. Chem. Ecol. | pmid:19730955 |
de Castro J et al. | Platelet linoleic acid is a potential biomarker of advanced non-small cell lung cancer. | 2009 | Exp. Mol. Pathol. | pmid:19733167 |
Queirós B et al. | In search of synergistic effects in antioxidant capacity of combined edible mushrooms. | 2009 | Int J Food Sci Nutr | pmid:19746297 |
Zhang Y and Wang ZZ | Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. | 2009 | C. R. Biol. | pmid:19748456 |
Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
Proudfoot JM et al. | HDL is the major lipoprotein carrier of plasma F2-isoprostanes. | 2009 | J. Lipid Res. | pmid:19050315 |
Hodson L et al. | Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18940935 |
Li Z et al. | Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. | 2009 | Chem. Phys. Lipids | pmid:19146841 |
Tribole E | What happened to do no harm? The issue of dietary omega-6 fatty acids. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147337 |
Ramsden CE et al. | Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147338 |
Lee CM et al. | SPION-loaded chitosan-linoleic acid nanoparticles to target hepatocytes. | 2009 | Int J Pharm | pmid:19138733 |
Staiger H et al. | Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. | 2009 | Diabetes | pmid:19074989 |
Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
Robinson NJ et al. | A potential role for free fatty acids in the pathogenesis of preeclampsia. | 2009 | J. Hypertens. | pmid:19462499 |
Adiguzel A et al. | Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria. | 2009 | Pol. J. Microbiol. | pmid:19469289 |
Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
Dauchy RT et al. | Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. | 2009 | J. Pineal Res. | pmid:19486272 |
Yano M et al. | Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. | 2009 | Hepatology | pmid:19492433 |
Tanaka N et al. | Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice. | 2009 | J. Gastroenterol. | pmid:19506795 |
Cho CW et al. | Enhanced transdermal delivery of loratadine from the EVA matrix. | 2009 | Drug Deliv | pmid:19514983 |
Khalili M et al. | Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum. | 2009 | Cell Biol. Int. | pmid:19524695 |
Damsgaard CT et al. | Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men. | 2009 | J. Nutr. | pmid:19494025 |
Zhang M et al. | Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. | 2009 | Chem. Biol. Interact. | pmid:19497410 |
Villa PM et al. | Free fatty acid profiles in preeclampsia. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19497719 |
Jeng JY et al. | Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19502730 |
Guyenet SJ | High-fat diets: details matter. | 2009 | Obesity (Silver Spring) | pmid:19553921 |
Zhang HM et al. | Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. | 2009 | PLoS ONE | pmid:19557129 |
Zhu X et al. | Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid. | 2009 | Chem. Res. Toxicol. | pmid:19537826 |
Quintana N et al. | Phytotoxic compounds from roots of Centaurea diffusa Lam. | 2009 | Plant Signal Behav | pmid:19568334 |
Alves BN et al. | Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). | 2009 | Cell Biochem. Funct. | pmid:19548271 |
Guillén MD and Uriarte PS | Contribution to further understanding of the evolution of sunflower oil submitted to frying temperature in a domestic fryer: study by 1H nuclear magnetic resonance. | 2009 | J. Agric. Food Chem. | pmid:19663427 |
Lux CA et al. | Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. | 2009 | Atherosclerosis | pmid:19423111 |
Hamel FG | Preliminary report: inhibition of cellular proteasome activity by free fatty acids. | 2009 | Metab. Clin. Exp. | pmid:19423142 |
Cheong SJ et al. | Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. | 2009 | Int J Pharm | pmid:19429277 |
Fukasawa R et al. | Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids. | 2009 | J Oleo Sci | pmid:19430189 |
Fang IM et al. | Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. | 2009 | Mol Nutr Food Res | pmid:19437483 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
Ozen T | Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. | 2009 Mar-Apr | Acta Pol Pharm | pmid:19719054 |
Zeng Z et al. | Identification of lactic acid bacterial strains with high conjugated linoleic acid-producing ability from natural sauerkraut fermentations. | 2009 May-Jul | J. Food Sci. | pmid:19490332 |
Kawakami Y et al. | Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. | 2009 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19457650 |
Parnas M et al. | Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. | 2009 May-Jun | Channels (Austin) | pmid:19535910 |
Yu C et al. | Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. | 2009 Nov-Dec | Plant Physiol. Biochem. | pmid:19648018 |
Habermann N et al. | Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. | 2009 Sep-Oct | Biofactors | pmid:19798733 |
Jung S et al. | Effect of dietary mixture of gallic acid and linoleic acid on antioxidative potential and quality of breast meat from broilers. | 2010 | Meat Sci. | pmid:20609528 |
Ross RA et al. | Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. | 2010 | Am. J. Physiol. Endocrinol. Metab. | pmid:20647558 |
Ohmori H et al. | Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. | 2010 | Pathobiology | pmid:20616616 |
Bartók T et al. | Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₠fumonisin isomers from a solid culture of Fusarium verticillioides. | 2010 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:21108092 |
Zaman MM et al. | Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20656894 |
Frangioudakis G et al. | Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. | 2010 | Endocrinology | pmid:20660065 |
Jernerén F et al. | Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. | 2010 | Biochim. Biophys. Acta | pmid:20045744 |
Paraszkiewicz K et al. | Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. | 2010 | Arch. Microbiol. | pmid:20047047 |
Esmaeili MA and Sonboli A | Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. | 2010 | Food Chem. Toxicol. | pmid:20036303 |
Jernerén F et al. | Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. | 2010 | Arch. Biochem. Biophys. | pmid:20043865 |
Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
Zidi A et al. | Pleiotropic effects of the goat prolactin receptor genotype on milk fatty acid composition. | 2010 | Domest. Anim. Endocrinol. | pmid:20399061 |
Köse EO et al. | Chemical composition, antimicrobial and antioxidant activities of the essential oils of Sideritis erythrantha Boiss. and Heldr. (var. erythrantha and var. cedretorum P.H. Davis) endemic in Turkey. | 2010 | Food Chem. Toxicol. | pmid:20670669 |
Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20673710 |
Takahashi S et al. | The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship. | 2010 | Biosci. Biotechnol. Biochem. | pmid:20699562 |
Vij N | Linoleic acid supplement in cystic fibrosis: friend or foe? | 2010 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:20709729 |
Noel JT et al. | Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. | 2010 | PLoS ONE | pmid:20824208 |
Macouzet M et al. | Genetic and structural comparison of linoleate isomerases from selected food-grade bacteria. | 2010 | J. Appl. Microbiol. | pmid:20825518 |
Collin F et al. | Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals. | 2010 | Biochimie | pmid:20685376 |
Calder PC | The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? | 2010 | Br. J. Nutr. | pmid:21118616 |
Ramsden CE et al. | n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. | 2010 | Br. J. Nutr. | pmid:21118617 |
Guo JJ and Hu CH | Mechanism of chain termination in lipid peroxidation by carotenes: a theoretical study. | 2010 | J Phys Chem B | pmid:21105679 |
Aluf Y et al. | Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydroxydopamine as assessed by a novel multifunctional marker molecule. | 2010 | Free Radic. Res. | pmid:20370558 |
Tume RK et al. | Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. | 2010 | Meat Sci. | pmid:20374755 |
Berthelot V et al. | Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. | 2010 | Meat Sci. | pmid:20374762 |
Della Casa G et al. | Performance and fat quality of heavy pigs fed maize differing in linoleic acid content. | 2010 | Meat Sci. | pmid:20374768 |
Aldai N et al. | Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. | 2010 | Meat Sci. | pmid:20374865 |
Bitis L et al. | Flavonoids and antioxidant activity of Rosa agrestis leaves. | 2010 | Nat. Prod. Res. | pmid:20397108 |
Kamkar A et al. | The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil. | 2010 | Food Chem. Toxicol. | pmid:20385193 |
Sarikurkcu C et al. | Essential oil composition and antioxidant activity of Thymus longicaulis C. Presl subsp. longicaulis var. longicaulis. | 2010 | Food Chem. Toxicol. | pmid:20385197 |
Litvinov D et al. | Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. | 2010 | Atherosclerosis | pmid:19880116 |
Friesen RW and Innis SM | Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. | 2010 | Am. J. Clin. Nutr. | pmid:19923368 |