Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Genetic Diseases, X-Linked D040181 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Lymphopenia D008231 2 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Melanosis D008548 4 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Otitis Externa D010032 8 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Coronary Restenosis D023903 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Bernhard W et al. Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. 2014 Eur J Nutr pmid:24464176
Jacob RH et al. Phenotypic characterisation of colour stability of lamb meat. 2014 Meat Sci. pmid:23415827
Corrêa RC et al. Antioxidant and rheological properties of guava jam with added concentrated grape juice. 2014 J. Sci. Food Agric. pmid:23696312
Shimamoto C et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. 2014 Hum. Mol. Genet. pmid:25027319
Hellstrand S et al. Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. 2014 J. Nutr. pmid:25008580
Hester AG et al. Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. 2014 J. Biol. Chem. pmid:24962583
Evans SJ et al. Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. 2014 J Psychiatr Res pmid:24953860
Moate PJ et al. Grape marc reduces methane emissions when fed to dairy cows. 2014 J. Dairy Sci. pmid:24952778
Mesti T et al. Metabolic impact of anti-angiogenic agents on U87 glioma cells. 2014 PLoS ONE pmid:24922514
Herchi W et al. Flaxseed hull: Chemical composition and antioxidant activity during development. 2014 J Oleo Sci pmid:24919478
Woyda-Ploszczyca AM and Jarmuszkiewicz W Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. 2014 PLoS ONE pmid:24904988
Maruyama H et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. 2014 Lipids Health Dis pmid:24885871
Nosaka S and Miyazawa M Characterization of volatile components and odor-active compounds in the oil of edible mushroom Boletopsis leucomelas. 2014 J Oleo Sci pmid:24881770
Chilton FH et al. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. 2014 Nutrients pmid:24853887
Saito H and Ishikawa S Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. 2014 J Oleo Sci pmid:24829130
Asselin C et al. Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. 2014 Redox Biol pmid:24494189
Mouradian M et al. Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24374147
Arfaoui MO et al. Variation in oil content, fatty acid and phytosterols profile of Onopordum acanthium L. during seed development. 2014 Nat. Prod. Res. pmid:25103576
Wright CR and Setzer WN Chemical composition of volatiles from Opuntia littoralis, Opuntia ficus-indica, and Opuntia prolifera growing on Catalina Island, California. 2014 Nat. Prod. Res. pmid:24354326
Usami A et al. Characteristic odorants from bailingu oyster mushroom (Pleurotus eryngii var. tuoliensis) and summer oyster mushroom (Pleurotus cystidiosus). 2014 J Oleo Sci pmid:24919476
Dal Bosco A et al. Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. 2014 Meat Sci. pmid:24036258
Wennman A et al. Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. 2014 Arch. Biochem. Biophys. pmid:24857825
López A et al. Compressive mechanical properties and cytocompatibility of bone-compliant, linoleic acid-modified bone cement in a bovine model. 2014 J Mech Behav Biomed Mater pmid:24508711
Yang Y et al. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. 2014 Lipids pmid:24777581
Bonferoni MC et al. Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid. 2014 Eur J Pharm Biopharm pmid:24384070
Stoffel W et al. Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. 2014 EMBO Rep. pmid:24378641
González-Abuín N et al. Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. 2014 Am. J. Physiol., Cell Physiol. pmid:24371039
Öztürk M et al. The fatty acid compositions of several plant seed oils belong to Leguminosae and Umbelliferae families. 2014 Environ Monit Assess pmid:24357269
Choi JS et al. In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. 2014 Biol. Pharm. Bull. pmid:24389480
Barua P et al. Seed oils from non-conventional sources in north-east India: potential feedstock for production of biodiesel. 2014 Nat. Prod. Res. pmid:24483850
Cho Y et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. 2014 Exp. Biol. Med. (Maywood) pmid:24495951
Matthaus B and Özcan MM Fatty acid and tocopherol contents of several soybean oils. 2014 Nat. Prod. Res. pmid:24499198
Dailey MJ et al. Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24452547
Shen J et al. A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. 2014 J. Exp. Bot. pmid:24453226
Mulligan CM et al. Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. 2014 J. Gerontol. A Biol. Sci. Med. Sci. pmid:24418793
Oh YT et al. Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. 2014 Endocrinology pmid:24424035
Ozdener MH et al. CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. 2014 Gastroenterology pmid:24412488
Hoffman LC et al. Lipid and protein stability and sensory evaluation of ostrich (Struthio camelus) droëwors with the addition of rooibos tea extract (Aspalathus linearis) as a natural antioxidant. 2014 Meat Sci. pmid:24334052
Breiden B and Sandhoff K The role of sphingolipid metabolism in cutaneous permeability barrier formation. 2014 Biochim. Biophys. Acta pmid:23954553
Ogorodnikova AV et al. Screening of divinyl ether synthase activity in nonphotosynthetic tissue of asparagales. 2013 Mar-Apr Dokl. Biochem. Biophys. pmid:23657662
Thomas CP et al. Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. 2013 Feb-Mar Chem. Phys. Lipids pmid:23352713
Otte KB et al. Synthesis of 9-oxononanoic acid, a precursor for biopolymers. 2013 ChemSusChem pmid:23934656
Klein-Wieringa IR et al. Adipocytes modulate the phenotype of human macrophages through secreted lipids. 2013 J. Immunol. pmid:23817431
Zeng G et al. Kinetics of heterogeneous reaction of ozone with linoleic acid and its dependence on temperature, physical state, RH, and ozone concentration. 2013 J Phys Chem A pmid:23347186
Graves JP et al. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. 2013 Drug Metab. Dispos. pmid:23315644
Bin Q et al. The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. 2013 Lipids pmid:23065354
Shimomura S et al. Stereoselective synthesis of a promising flower-inducing KODA analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid. 2013 Biosci. Biotechnol. Biochem. pmid:23748793
Herrera-Meza MS et al. Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. 2013 Int J Food Sci Nutr pmid:23360131
Li P et al. Effect of non-esterified fatty acids on fatty acid metabolism-related genes in calf hepatocytes cultured in vitro. 2013 Cell. Physiol. Biochem. pmid:24335176
Sato K et al. Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. 2013 J Smooth Muscle Res pmid:24304639