Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Guarini P et al. | Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion. | 1998 | Inflammation | pmid:9675609 |
Kelly ML et al. | Effect of intake of pasture on concentrations of conjugated linoleic acid in milk of lactating cows. | 1998 | J. Dairy Sci. | pmid:9684170 |
Demmelmair H et al. | Metabolism of U13C-labeled linoleic acid in lactating women. | 1998 | J. Lipid Res. | pmid:9684741 |
Kang LT and Vanderhoek JY | Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. | 1998 | J. Lipid Res. | pmid:9684751 |
Kato M et al. | Reactivity of soybean lipoxygenase-1 to linoleic acid entrapped in phosphatidylcholine vesicles. | 1998 | J. Biochem. | pmid:9685717 |
Fungwe TV et al. | Fatty acids modulate lecithin:cholesterol acyltransferase secretion independently of effects on triglyceride secretion in primary rat hepatocytes. | 1998 | J. Nutr. | pmid:9687543 |
Letawe C et al. | Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones. | 1998 | Clin. Exp. Dermatol. | pmid:9692305 |
Hsu AF et al. | Characterization of soybean lipoxygenase immobilized in cross-linked phyllosilicates. | 1998 | Biotechnol. Appl. Biochem. | pmid:9693089 |
Goodrich-Tanrikulu M et al. | Changes in fatty acid composition of Neurospora crassa accompany sexual development and ascospore germination. | 1998 | Microbiology (Reading, Engl.) | pmid:9695905 |
Yamaguchi H et al. | High transepidermal water loss induces fatty acid synthesis and cutaneous fatty acid-binding protein expression in rat skin. | 1998 | J. Dermatol. Sci. | pmid:9697049 |
KmonÃcková E et al. | Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions. | 1998 | Physiol Res | pmid:9706993 |
Ondrias K et al. | Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes. | 1998 | Physiol Res | pmid:9706995 |
Butovich IA et al. | Oxidation of linoleyl alcohol by potato tuber lipoxygenase: possible mechanism and the role of carboxylic group in substrate binding. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9712698 |
Konrad SD et al. | Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. | 1998 | Biochim. Biophys. Acta | pmid:9714781 |
Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
West DB et al. | Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. | 1998 | Am. J. Physiol. | pmid:9728060 |
Wilson TA et al. | Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate. | 1998 | Atherosclerosis | pmid:9733225 |
Sentex E et al. | Is the cytoprotective effect of trimetazidine associated with lipid metabolism? | 1998 | Am. J. Cardiol. | pmid:9737482 |
Fidler N et al. | Effects of human milk pasteurization and sterilization on available fat content and fatty acid composition. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9740204 |
Liu JH et al. | Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. | 1998 | Planta Med. | pmid:9741298 |
Rodriguez A et al. | Delta6- and delta5-desaturase activities in the human fetal liver: kinetic aspects. | 1998 | J. Lipid Res. | pmid:9741695 |
Sluse FE et al. | Free fatty acids regulate the uncoupling protein and alternative oxidase activities in plant mitochondria. | 1998 | FEBS Lett. | pmid:9744802 |
Romijn D et al. | A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. | 1998 | Ann. Nutr. Metab. | pmid:9745111 |
Berdeaux O et al. | In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes. | 1998 | Mol. Cell. Biochem. | pmid:9746207 |
Kanazawa K and Ashida H | Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. | 1998 | Biochim. Biophys. Acta | pmid:9748647 |
Kanazawa K and Ashida H | Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. | 1998 | Biochim. Biophys. Acta | pmid:9748650 |
Kuratko CN and Constante BJ | Linoleic acid and tumor necrosis factor-alpha increase manganese superoxide dismutase activity in intestinal cells. | 1998 | Cancer Lett. | pmid:9751273 |
Spalinger JH et al. | Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. | 1998 | Am. J. Physiol. | pmid:9756493 |
Obukowicz MG et al. | Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9765335 |
Iwamoto S et al. | Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. | 1998 | Nutr Cancer | pmid:9770727 |
Hu ZY et al. | cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. | 1998 | Biochim. Biophys. Acta | pmid:9784625 |
Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
Bretillon L et al. | Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. | 1998 | J. Lipid Res. | pmid:9799809 |
Cunnane SC et al. | Substantial carbon recycling from linoleate into products of de novo lipogenesis occurs in rat liver even under conditions of extreme dietary linoleate deficiency. | 1998 | J. Lipid Res. | pmid:9799813 |
Masia A et al. | Enrichment with a polyunsaturated fatty acid enhances the survival of Saccharomyces cerevisiae in the presence of tributyltin. | 1998 | FEMS Microbiol. Lett. | pmid:9809434 |
Broun P et al. | Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids. | 1998 | Science | pmid:9812895 |
Morita Y et al. | Involvement of lipid peroxidation in free fatty acid-induced isolated rat pancreatic acinar cell injury. | 1998 | Pancreas | pmid:9821180 |
Gu JY et al. | Effect of dietary fats and sesamin on the lipid metabolism and immune function of Sprague-Dawley rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9836427 |
Iwase H et al. | Calcium is required for quasi-lipoxygenase activity of hemoproteins. | 1998 | Free Radic. Biol. Med. | pmid:9840740 |
Phifer CB and Berthoud HR | Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. | 1998 | Am. J. Physiol. | pmid:9841547 |
Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844997 |
Oyama Y et al. | Protective actions of 5'-n-alkylated curcumins on living cells suffering from oxidative stress. | 1998 | Eur. J. Pharmacol. | pmid:9845274 |
Nestel PJ et al. | Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations. | 1998 | Am. J. Clin. Nutr. | pmid:9846846 |
Spiteller G | Linoleic acid peroxidation--the dominant lipid peroxidation process in low density lipoprotein--and its relationship to chronic diseases. | 1998 | Chem. Phys. Lipids | pmid:9853364 |
Jarmuszkiewicz W et al. | Linoleic acid-induced activity of plant uncoupling mitochondrial protein in purified tomato fruit mitochondria during resting, phosphorylating, and progressively uncoupled respiration. | 1998 | J. Biol. Chem. | pmid:9857016 |
Hudson JA et al. | Hydration of linoleic acid by bacteria isolated from ruminants. | 1998 | FEMS Microbiol. Lett. | pmid:9868771 |
Blaauwwiekel EE et al. | Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion. | 1998 | Diabet. Med. | pmid:9868977 |
Kim EJ et al. | Development of a serum-free medium for the production of humanized antibody from Chinese hamster ovary cells using a statistical design. | 1998 Nov-Dec | In Vitro Cell. Dev. Biol. Anim. | pmid:9870524 |
Akeo K and Hiramitsu T | Changes in lipid peroxide level in retinal pigment epithelial cells in vitro upon addition of linoleic acids or linoleic acid hydroperoxides under varying concentrations of oxygen. | 1998 | Pigment Cell Res. | pmid:9877104 |
Tsimikas S et al. | LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:9888874 |