| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jump DB et al. | Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. | 2011 | Biochem. Pharmacol. | pmid:21184748 |
| Penumetcha M et al. | Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? | 2011 | J Med Food | pmid:21186986 |
| Loizzo MR et al. | In vitro antioxidant and hypoglycemic activities of Ethiopian spice blend Berbere. | 2011 | Int J Food Sci Nutr | pmid:21599464 |
| Shin D et al. | Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. | 2011 | Poult. Sci. | pmid:21597077 |
| Nigam S et al. | On mechanism of quorum sensing in Candida albicans by 3(R)-hydroxy-tetradecaenoic acid. | 2011 | Curr. Microbiol. | pmid:20509029 |
| Liu SJ et al. | Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. | 2011 | J. Dairy Sci. | pmid:21605768 |
| Palmieri-Thiers C et al. | Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. | 2011 | Arch. Biochem. Biophys. | pmid:21345329 |
| McFarland DC et al. | Effect of lipids on avian satellite cell proliferation, differentiation and heparan sulfate proteoglycan expression. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21356326 |
| Prasad A and PospÃÅ¡il P | Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. | 2011 | PLoS ONE | pmid:21799835 |
| Shofian NM et al. | Effect of freeze-drying on the antioxidant compounds and antioxidant activity of selected tropical fruits. | 2011 | Int J Mol Sci | pmid:21845104 |
| Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
| Toledo L et al. | Substrate binding to mammalian 15-lipoxygenase. | 2011 | J. Comput. Aided Mol. Des. | pmid:21861154 |
| Vedtofte MS et al. | Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. | 2011 | Am. J. Clin. Nutr. | pmid:21865326 |
| Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
| Okuyama H et al. | New Cholesterol Guidelines for Longevity (2010). | 2011 | World Rev Nutr Diet | pmid:21865826 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Khan AA et al. | Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study. | 2011 | Eur J Med Chem | pmid:21868138 |
| Simon E et al. | Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression. | 2011 | Exp. Eye Res. | pmid:21821023 |
| Arawwawala M et al. | In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. | 2011 | Acta. Biol. Hung. | pmid:21840826 |
| Bowden JA et al. | Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. | 2011 | Lipids | pmid:21904795 |
| Aktumsek A et al. | Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L. species from Turkey flora. | 2011 | Food Chem. Toxicol. | pmid:21878362 |
| Guesnet P et al. | α-Linolenate reduces the dietary requirement for linoleate in the growing rat. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21880475 |
| Dailey MJ et al. | Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21917638 |
| Lee YJ and Jenkins TC | Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. | 2011 | J. Microbiol. | pmid:21887646 |
| Odabasoglu F et al. | α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. | 2011 | Br. J. Nutr. | pmid:21073761 |
| Cheng TM et al. | Haemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids. | 2011 | Free Radic. Res. | pmid:21034361 |
| Lin YH et al. | Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. | 2011 | J. Nutr. Biochem. | pmid:21111595 |
| Lam WM et al. | In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. | 2011 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:21053263 |
| Chen Q et al. | Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21679695 |
| Pink RC et al. | Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism. | 2011 | Nutr Cancer | pmid:21667399 |
| Morganti P et al. | Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial. | 2011 | Int J Cosmet Sci | pmid:21668835 |
| Narwaley M et al. | Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites. | 2011 | Chem. Res. Toxicol. | pmid:21671642 |
| Göçer H and Gülçin I | Caffeic acid phenethyl ester (CAPE): correlation of structure and antioxidant properties. | 2011 | Int J Food Sci Nutr | pmid:21631390 |
| Lautenslager GT et al. | Effects of nonenzymatic glycation and fatty acids on functional properties of human albumin. | 2011 | Metab. Clin. Exp. | pmid:21632076 |
| Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
| Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
| Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |
| Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
| Aewsiri T et al. | Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. | 2011 | Int. J. Biol. Macromol. | pmid:21334373 |
| You Q et al. | Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. | 2011 | Bioprocess Biosyst Eng | pmid:21340675 |
| Serratosa MP et al. | Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. | 2011 | J. Agric. Food Chem. | pmid:21319807 |
| Litinas KE et al. | Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers. | 2011 | J Enzyme Inhib Med Chem | pmid:21381887 |
| Zouboulis CC et al. | Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. | 2011 | Br. J. Dermatol. | pmid:21457203 |
| Alloatti A and Uttaro AD | Highly specific methyl-end fatty-acid desaturases of trypanosomatids. | 2011 | Mol. Biochem. Parasitol. | pmid:20974196 |
| Konkel A and Schunck WH | Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. | 2011 | Biochim. Biophys. Acta | pmid:20869469 |
| Perona JS et al. | Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. | 2011 | Metab. Clin. Exp. | pmid:20934731 |
| Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
| Pan Z et al. | Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21295151 |
| Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |
| Rosberg-Cody E et al. | Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. | 2011 | Microbiology (Reading, Engl.) | pmid:21178166 |