Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia D007938 74 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
CHRISTAKIS GJ et al. EFFECT OF A SERUM CHOLESTEROL-LOWERING DIET ON COMPOSITION OF DEPOT FAT IN MAN. 1965 Am. J. Clin. Nutr. pmid:14253897
ZUKEL MC FAT-CONTROLLED DIETS. 1965 Am. J. Clin. Nutr. pmid:14253901
Higdon JV et al. Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. 2000 Am. J. Clin. Nutr. pmid:10966889
CAMPBELL AM et al. SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. 1965 Am. J. Clin. Nutr. pmid:14332349
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. 1987 Am. J. Clin. Nutr. pmid:3310599
Kark JD et al. Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. 2003 Am. J. Clin. Nutr. pmid:12663274
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Glatz JF et al. Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. 1989 Am. J. Clin. Nutr. pmid:2916448
KRAUSE RF LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A. 1965 Am. J. Clin. Nutr. pmid:14301352
Turpeinen AM et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. 2002 Am. J. Clin. Nutr. pmid:12197992
Martinelli N et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. 2008 Am. J. Clin. Nutr. pmid:18842780
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
SCOTT RF et al. FATTY ACIDS OF SERUM AND ADIPOSE TISSUE IN SIX GROUPS EATING NATURAL DIETS CONTAINING 7 TO 40 PER CENT FAT. 1964 Am. J. Clin. Nutr. pmid:14157830
DeLany JP et al. Differential oxidation of individual dietary fatty acids in humans. 2000 Am. J. Clin. Nutr. pmid:11010930
Mantzioris E et al. Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. 1995 Am. J. Clin. Nutr. pmid:7840069
Siguel E Does linoleic acid contribute to coronary artery disease? 1995 Am. J. Clin. Nutr. pmid:7840081
O'Connell ED et al. Diet and risk factors for age-related maculopathy. 2008 Am. J. Clin. Nutr. pmid:18326611
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Martin JC et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. 1991 Am. J. Clin. Nutr. pmid:1951153
Del Prado M et al. Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. 2001 Am. J. Clin. Nutr. pmid:11470727
Carnielli VP et al. Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. 1996 Am. J. Clin. Nutr. pmid:8694014
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
HOLMAN RT et al. ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. 1964 Am. J. Clin. Nutr. pmid:14142377
Rudel LL et al. Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. 1995 Am. J. Clin. Nutr. pmid:7625361
Cunnane SC et al. Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. 1989 Am. J. Clin. Nutr. pmid:2801584
Reeves VB et al. Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. 1984 Am. J. Clin. Nutr. pmid:6507356
Green P et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. 1990 Am. J. Clin. Nutr. pmid:2239789
Sanders TA Polyunsaturated fatty acids in the food chain in Europe. 2000 Am. J. Clin. Nutr. pmid:10617968
Uauy R and Hoffman DR Essential fat requirements of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617979
Gibson RA and Makrides M n-3 polyunsaturated fatty acid requirements of term infants. 2000 Am. J. Clin. Nutr. pmid:10617980
Crawford M Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617983
Adam O and Wolfram G Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. 1984 Am. J. Clin. Nutr. pmid:6486083
Dutta-Roy AK Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. 2000 Am. J. Clin. Nutr. pmid:10617989
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Ziboh VA et al. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. 2000 Am. J. Clin. Nutr. pmid:10617998
Kalivianakis M et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. 1999 Am. J. Clin. Nutr. pmid:9925134
SINGLETON WS CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. 1965 Am. J. Clin. Nutr. pmid:14262113
Hodgson JM et al. Can linoleic acid contribute to coronary artery disease? 1993 Am. J. Clin. Nutr. pmid:8192728
Truswell AS Can linoleic acid contribute to coronary artery disease? 1994 Am. J. Clin. Nutr. pmid:8198070
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Murphy J et al. Fat malabsorption in cystic fibrosis patients. 1999 Am. J. Clin. Nutr. pmid:10539762
Terpstra AH Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature. 2004 Am. J. Clin. Nutr. pmid:14985207
Rose DP Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. 1997 Am. J. Clin. Nutr. pmid:9394709
Ip C Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. 1997 Am. J. Clin. Nutr. pmid:9394710
Willett WC Specific fatty acids and risks of breast and prostate cancer: dietary intake. 1997 Am. J. Clin. Nutr. pmid:9394715
Friesen RW and Innis SM Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. 2010 Am. J. Clin. Nutr. pmid:19923368
Almario RU et al. Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia. 2001 Am. J. Clin. Nutr. pmid:11451720
Nestel PJ et al. Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations. 1998 Am. J. Clin. Nutr. pmid:9846846
Hodge AM et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. 2007 Am. J. Clin. Nutr. pmid:17616780