Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Strauss JS et al. The effect of 13-cis-retinoic acid on sebaceous glands. 1987 Arch Dermatol pmid:2960273
Wertz PW et al. Essential fatty acids and epidermal integrity. 1987 Arch Dermatol pmid:3310912
Oxholm A et al. Abnormal essential fatty acid metabolism in Darier's disease. 1990 Arch Dermatol pmid:1977367
Khodadadi I et al. Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. 2008 Arch Iran Med pmid:18154422
Muakkassa FF et al. Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. 1991 Arch Surg pmid:1992995
Volpe JJ and Obert KA Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. 1981 Arch. Biochem. Biophys. pmid:6118099
Shichiri G et al. Polyunsaturated fatty acid metabolism and acetylated low density lipoprotein uptake in J774A.1 cells. 1993 Arch. Biochem. Biophys. pmid:8099780
Glasgow WC and Eling TE Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. 1994 Arch. Biochem. Biophys. pmid:8203891
Sutherland MW and Gebicki JM A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles. 1982 Arch. Biochem. Biophys. pmid:6282219
CENTURY B and HORWITT MK ROLE OF ARACHIDONIC ACID IN NUTRITIONAL ENCEPHALOMALACIA: INTERRELATIONSHIP OF ESSENTIAL AND NONESSENTIAL POLYUNSATURATED FATTY ACIDS. 1964 Arch. Biochem. Biophys. pmid:14161009
BRESSLER R and FRIEDBERG SJ SUBSTRATE SPECIFICITY OF THE FATTY ACID OXIDASE IN THE HEART. 1964 Arch. Biochem. Biophys. pmid:14161011
KLEIN PD Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. 1958 Arch. Biochem. Biophys. pmid:13560012
Jernerén F et al. Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. 2010 Arch. Biochem. Biophys. pmid:20043865
Galaris D et al. Ferrylmyoglobin-catalyzed linoleic acid peroxidation. 1990 Arch. Biochem. Biophys. pmid:2383021
PORTMAN OW and SUGANO M THE HYDROLYSIS AND FATTY ACID EXCHANGE OF CHOLESTEROL ESTERS ADMINISTERED IN LIPOPROTEINS TO CEBUS MONKEYS. 1963 Arch. Biochem. Biophys. pmid:14072510
Winterbourn CC et al. Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid. 1992 Arch. Biochem. Biophys. pmid:1321589
MATSUSHITA S et al. CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS. 1963 Arch. Biochem. Biophys. pmid:14072524
Kearns EV et al. The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). 1991 Arch. Biochem. Biophys. pmid:1989527
KLEIN PD Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. 1959 Arch. Biochem. Biophys. pmid:13638000
Hicks M et al. Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation. 1989 Arch. Biochem. Biophys. pmid:2492180
Gerwick WH et al. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. 1991 Arch. Biochem. Biophys. pmid:1929410
Draper AJ and Hammock BD Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. 2000 Arch. Biochem. Biophys. pmid:10729206
Loftin CD and Eling TE Prostaglandin synthase 2 expression in epidermal growth factor-dependent proliferation of mouse keratinocytes. 1996 Arch. Biochem. Biophys. pmid:8660674
Fukuzawa K et al. Peroxide-dependent and -independent lipid peroxidations catalyzed by chelated iron. 1991 Arch. Biochem. Biophys. pmid:1656881
VAHOUNY GV et al. MICELLAR-SOLUBILIZED SUBSTRATES AND CHOLESTEROL ESTERASE ACTIVITY IN VITRO. 1964 Arch. Biochem. Biophys. pmid:14211570
Hamberg M et al. Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. 1994 Arch. Biochem. Biophys. pmid:8117115
VIOQUE E and HOLMAN RT Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase. 1962 Arch. Biochem. Biophys. pmid:13997422
Moon HS et al. Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis. 2006 Arch. Biochem. Biophys. pmid:17084379
PORTMAN OW and SUGANO M FACTORS INFLUENCING THE LEVEL AND FATTY ACID SPECIFICITY OF THE CHOLESTEROL ESTERIFICATION ACTIVITY IN HUMAN PLASMA. 1964 Arch. Biochem. Biophys. pmid:14236639
JACKSON HD et al. FORMATION OF KETONE BODIES FROM LONG-CHAIN FATTY ACIDS IN RUMEN EPITHELIUM AND LIVER FROM KETOTIC SHEEP. 1964 Arch. Biochem. Biophys. pmid:14240563
Ashida H et al. Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. 1987 Arch. Biochem. Biophys. pmid:3688880
Bafor M et al. Biosynthesis of vernoleate (cis-12-epoxyoctadeca-cis-9-enoate) in microsomal preparations from developing endosperm of Euphorbia lagascae. 1993 Arch. Biochem. Biophys. pmid:8489257
Hennig B et al. Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. 1986 Arch. Biochem. Biophys. pmid:3729421
Oliw EH et al. Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids. 1993 Arch. Biochem. Biophys. pmid:8424677
PEIFER JJ et al. Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. 1960 Arch. Biochem. Biophys. pmid:14431396
MEDES G et al. Dienoic acid contents of rats with linoleic acid and pyridoxine deficiencies. 1951 Arch. Biochem. Biophys. pmid:14847665
Kaneko T et al. Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. 1993 Arch. Biochem. Biophys. pmid:8323284
Kulkarni AP and Sajan M Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. 1999 Arch. Biochem. Biophys. pmid:10545208
Behrends W et al. The glyoxysomal beta-oxidation system in cucumber seedlings: identification of enzymes required for the degradation of unsaturated fatty acids. 1988 Arch. Biochem. Biophys. pmid:3369861
Angerman-Stewart JA et al. Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. 1995 Arch. Biochem. Biophys. pmid:7733666
Duthie GG et al. Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. 1992 Arch. Biochem. Biophys. pmid:1632646
PRIVETT OS et al. Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. 1955 Arch. Biochem. Biophys. pmid:13239196
TAPPEL AL et al. Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. 1953 Arch. Biochem. Biophys. pmid:13031632
TAPPEL AL The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. 1953 Arch. Biochem. Biophys. pmid:13058395
Kawajiri H et al. Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. 2002 Arch. Biochem. Biophys. pmid:11811948
Nemecz G et al. Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. 1991 Arch. Biochem. Biophys. pmid:1897956
SIDDIQI AM and TAPPEL AL Catalysis of linoleate oxidation by pea lipoxidase. 1956 Arch. Biochem. Biophys. pmid:13283592
SWELL L et al. ROLE OF THE LIVER IN THE METABOLISM OF EXOGENOUS CHOLESTEROL ESTERS. 1964 Arch. Biochem. Biophys. pmid:14236640
KOCH RB et al. Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). 1958 Arch. Biochem. Biophys. pmid:13595914
Fukuzawa K et al. Site-specific induction of lipid peroxidation by iron in charged micelles. 1988 Arch. Biochem. Biophys. pmid:2829725