| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Anorexia | D000855 | 8 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Constipation | D003248 | 8 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Heart Defects, Congenital | D006330 | 20 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
| Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
| Cardot P et al. | Essential fatty acid deficiency during pregnancy in the rat: influence of dietary carbohydrates. | 1987 | J. Nutr. | pmid:3116179 |
| Cunnane SC and McAdoo KR | Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes. | 1987 | J. Nutr. | pmid:3116180 |
| Mikhailidis DP et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1987 | Eur. J. Clin. Invest. | pmid:3106056 |
| Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
| Bandyopadhyay GK et al. | Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor. | 1987 | J. Biol. Chem. | pmid:3102474 |
| Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
| Haines KA et al. | The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. | 1987 | Biochem. J. | pmid:3032161 |
| Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
| Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
| Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
| Takahashi R et al. | Impaired platelet aggregation and thromboxane generation in essential fatty acid-deficient rats. | 1987 | J. Nutr. | pmid:2888839 |
| Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
| Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
| Dormandy TL and Wickens DG | The experimental and clinical pathology of diene conjugation. | 1987 Nov-Dec | Chem. Phys. Lipids | pmid:3319233 |
| Loscalzo J et al. | Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. | 1987 Sep-Oct | Arteriosclerosis | pmid:3675304 |
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Hubbard NE et al. | Inhibition of growth and linoleate-enhanced metastasis of a transplantable mouse mammary tumor by indomethacin. | 1988 | Cancer Lett. | pmid:3203321 |
| Hicks M et al. | Catalysis of lipid peroxidation by glucose and glycosylated collagen. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3126742 |
| Bandyopadhyay GK et al. | Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2. | 1988 | J. Biol. Chem. | pmid:3286636 |
| De Deckere EA et al. | Effects of type and amount of dietary fat on rabbit and rat lymphocyte proliferation in vitro. | 1988 | J. Nutr. | pmid:3257261 |
| Perez RV et al. | Dietary immunoregulation of transfusion-induced immunosuppression. | 1988 | Transplantation | pmid:3258077 |
| Collier A et al. | Reduced free radical activity detected by decreased diene conjugates in insulin-dependent diabetic patients. | 1988 | Diabet. Med. | pmid:2975566 |
| Parsons HG et al. | Supplemental calories improve essential fatty acid deficiency in cystic fibrosis patients. | 1988 | Pediatr. Res. | pmid:3211621 |
| Solakivi T et al. | Plasma apolipoprotein B in middle-aged Finnish men. Evidence for a regional gradient of apo B and lack of negative correlation between apo B and dietary linoleate in hyperapobetalipoproteinemia. | 1988 | Atherosclerosis | pmid:3214459 |
| Schächtele C et al. | Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831891 |
| Cutts JL and Melnykovych G | Defective utilization of cholesterol esters from low-density lipoprotein in a human acute lymphoblastic leukemia T cell line. | 1988 | Biochim. Biophys. Acta | pmid:3260113 |
| MacKenzie LW et al. | Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. | 1988 | Am. J. Obstet. Gynecol. | pmid:3144917 |
| Benadé AJ et al. | Plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined Vervet monkeys. | 1988 | Atherosclerosis | pmid:3145748 |
| Sauer LA and Dauchy RT | Identification of linoleic and arachidonic acids as the factors in hyperlipemic blood that increase [3H]thymidine incorporation in hepatoma 7288CTC perfused in situ. | 1988 | Cancer Res. | pmid:3130186 |
| Salafsky B et al. | Schistosoma mansoni: analysis of cercarial transformation methods. | 1988 | Exp. Parasitol. | pmid:2458958 |
| Garg ML et al. | Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. | 1988 | Biochim. Biophys. Acta | pmid:2844278 |
| Wright JR et al. | Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3045812 |
| Palmblad J and Gyllenhammar H | Effect of dietary lipids on immunity and inflammation. Review article. | 1988 | APMIS | pmid:2841953 |
| Albro PW et al. | Comparison of the effects of carbon tetrachloride and of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the disposition of linoleic acid in rat liver in vitro. | 1988 | Chem. Biol. Interact. | pmid:3135123 |
| Staats DA et al. | Effects of tocopherol depletion on the regional differences in adrenal microsomal lipid peroxidation and steroid metabolism. | 1988 | Endocrinology | pmid:3135177 |
| Craven PA and DeRubertis FR | Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation by unsaturated fatty acids. | 1988 | Gastroenterology | pmid:3135225 |
| Nakagawa Y and Waku K | Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3142466 |
| Pschera H et al. | The influence of copper intrauterine device on fatty acid composition of cervical mucus lecithin. | 1988 | Contraception | pmid:3168451 |
| Kawooya JK and Law JH | Role of lipophorin in lipid transport to the insect egg. | 1988 | J. Biol. Chem. | pmid:3379043 |
| Asciutti-Moura LS et al. | Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. | 1988 | Am. J. Clin. Nutr. | pmid:3421207 |
| Griffiths G et al. | Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). | 1988 | Biochem. J. | pmid:3421914 |
| Casteels M et al. | Inhibition of 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholestanoic acid oxidation and of bile acid secretion in rat liver by fatty acids. | 1988 | J. Biol. Chem. | pmid:3350807 |
| Shasby DM et al. | Oxidants and conductance of cultured epithelial cell monolayers: inositol phospholipid hydrolysis. | 1988 | Am. J. Physiol. | pmid:3144179 |
| Spector R | Fatty acid transport through the blood-brain barrier. | 1988 | J. Neurochem. | pmid:3335863 |
| Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
| Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
| Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |
| Fukuzawa K et al. | Site-specific induction of lipid peroxidation by iron in charged micelles. | 1988 | Arch. Biochem. Biophys. | pmid:2829725 |