Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alopecia D000505 14 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Aortic Diseases D001018 11 associated lipids
Arteriosclerosis D001161 86 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Glioma D005910 112 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
HORGAN VJ et al. Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. 1957 Biochem. J. pmid:13488907
López-Nicolás JM et al. Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. 1995 Biochem. J. pmid:7755559
Enser M and Roberts JL The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. 1982 Biochem. J. pmid:6128973
Schlame M and Rüstow B Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. 1990 Biochem. J. pmid:2268287
HARRIS RV and JAMES AT CONVERSION OF OLEIC ACID INTO LINOLEIC ACID BY A SUBCELLULAR SYSTEM OF CHLORELLA VULGARIS. 1965 Biochem. J. pmid:14346083
Jones AL et al. Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. 1993 Biochem. J. pmid:8250841
Moore JP et al. The predominant polyphenol in the leaves of the resurrection plant Myrothamnus flabellifolius, 3,4,5 tri-O-galloylquinic acid, protects membranes against desiccation and free radical-induced oxidation. 2005 Biochem. J. pmid:15355309
Clouet P et al. Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. 1989 Biochem. J. pmid:2597132
Williams JP et al. The role of phosphatidylcholine in fatty acid exchange and desaturation in Brassica napus L. leaves. 2000 Biochem. J. pmid:10861220
Stymne S and Stobart AK Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). 1986 Biochem. J. pmid:3028375
Reid JC and Husbands DR Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. 1985 Biochem. J. pmid:3977825
Patel RP et al. Reduction of Cu(II) by lipid hydroperoxides: implications for the copper-dependent oxidation of low-density lipoprotein. 1997 Biochem. J. pmid:9065759
Butler M et al. Unsaturated fatty acids enhance cell yields and perturb the energy metabolism of an antibody-secreting hybridoma. 1997 Biochem. J. pmid:9065785
Swida A et al. Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. 2008 Biochem. J. pmid:18402555
JAMES AT et al. THE BIOSYNTHESIS OF RICINOLEIC ACID. 1965 Biochem. J. pmid:14340094
Nguyen SD and Sok DE Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. 2003 Biochem. J. pmid:12871208
Thuillier P et al. Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. 2002 Biochem. J. pmid:12069687
Calder PC et al. Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. 1994 Biochem. J. pmid:8141773
Schaloske R et al. Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. 1998 Biochem. J. pmid:9601085
Finn RD et al. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. 2009 Biochem. J. pmid:18778245
Naval J et al. Alternative route for the biosynthesis of polyunsaturated fatty acids in K562 cells. 1993 Biochem. J. pmid:8489510
Kang JX et al. The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. 1992 Biochem. J. pmid:1323271
Koshiishi I et al. Radical scavenger can scavenge lipid allyl radicals complexed with lipoxygenase at lower oxygen content. 2006 Biochem. J. pmid:16396633
Luévano-Martínez LA et al. A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. 2012 Biochem. J. pmid:22236206
Stymne S and Stobart AK The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). 1984 Biochem. J. pmid:6743281
Gavigan SJ and Knight BL The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. 1983 Biochem. J. pmid:6651782
O'donnell VB and Kühn H Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. 1997 Biochem. J. pmid:9355754
Haines KA et al. The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. 1987 Biochem. J. pmid:3032161
Louet JF et al. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. 2001 Biochem. J. pmid:11171094
Jones AL et al. Temperature-induced membrane-lipid adaptation in Acanthamoeba castellanii. 1993 Biochem. J. pmid:8439295
Fraenkel G and Blewett M Linoleic acid and arachidonic acid in the metabolism of two insects, Ephestia kuehniella (Lep.) and Tenebrio molitor (Col.). 1947 Biochem. J. pmid:16748194
Ando H et al. Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. 2006 Biochem. J. pmid:16232122
Brodhun F et al. PpoC from Aspergillus nidulans is a fusion protein with only one active haem. 2010 Biochem. J. pmid:19878096
Grechkin AN et al. The lipoxygenase pathway in tulip (Tulipa gesneriana): detection of the ketol route. 2000 Biochem. J. pmid:11085944
Huang YS et al. Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. 1994 Biochem. Med. Metab. Biol. pmid:7910749
Poisson JP et al. Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. 1993 Biochem. Med. Metab. Biol. pmid:8382502
Murphy MG et al. Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells. 1987 Biochem. Pharmacol. pmid:2825714
Bomalaski JS et al. Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. 1987 Biochem. Pharmacol. pmid:3117063
Medini L et al. Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. 1990 Biochem. Pharmacol. pmid:2105092
Demant EJ and Wassermann K Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. 1985 Biochem. Pharmacol. pmid:4004891
Clark DL and Queener SF Effects of diabetes mellitus on renal fatty acid activation and desaturation. 1985 Biochem. Pharmacol. pmid:4074391
Kawashima Y et al. Reduction by clofibric acid of serum arachidonic acid in rats. Effect on the acyl composition of renal phospholipids. 1992 Biochem. Pharmacol. pmid:1610396
Blond JP et al. Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. 1989 Biochem. Pharmacol. pmid:2764996
Hudson EA et al. Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. 1993 Biochem. Pharmacol. pmid:8517859
Sauer LA et al. Polyunsaturated fatty acids, melatonin, and cancer prevention. 2001 Biochem. Pharmacol. pmid:11377374
Allgayer H et al. Superoxide, hydroxyl and fatty acid radical scavenging by aminosalicylates. Direct evaluation with electron spin resonance spectroscopy. 1992 Biochem. Pharmacol. pmid:1310851
Goldmacher VS Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. 1983 Biochem. Pharmacol. pmid:6189496
Masini E et al. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. 1990 Biochem. Pharmacol. pmid:1690007
Castańeda-Hernández G Presence of endogenous digitalis-like activity in mammalian heart not due to fatty acids. 1987 Biochem. Pharmacol. pmid:3036154
Altmann R et al. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. 2007 Biochem. Pharmacol. pmid:17604003